CAS: 830-03-5; 4-Nitrophenyl Acetate

该化合物是一种有机化合物,其特征为酯性功能组,由乙酸和4-硝基苯酯反应形成,典型的黄色黄色液体,有甜味和果味,在乙醇和乙醚等有机溶剂中溶解,但因其水分芳香环在水中溶解性有限;苯环上存在硝基苯组,增强了其再活动性,使其在各种化学反应中有用,包括核生殖器替代;乙酸,4-硝基苯酯经常用于有机合成,特别是在制药和农用化学剂的制作过程中;必须小心处理该化合物,因为它可能会对皮肤和眼睛产生刺激,在使用过程中应当采取适当的安全措施;此外,该化合物被归类为一种危险物质,需要按照管制准则妥善储存和处置.

结构式图片

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

CAS号100-02-7 对硝基苯酚 | CAS号108-24-7 乙酸酐 | CAS号155164-63-9 2-乙酰基-4,5-二氯-3(... | CAS号75-36-5 乙酰氯 | CAS号100-00-5 对硝基氯苯 | CAS号37441-95-5 1-(2-thioxobenz... | CAS号64-19-7 冰醋酸 | CAS号506-96-7 乙酰溴 | CAS号1145-76-2 1-苄氧基-4-硝基苯 | CAS号108-22-5 醋酸异丙烯酯 | CAS号100-02-7 对硝基苯酚 | CAS号546-89-4 醋酸锂 | CAS号406-95-1 2,2,2-三氟乙酸乙酯 | CAS号57470-78-7 盐酸塞利洛尔 | CAS号35065-86-2 3-溴乙酸苯酯 | CAS号14609-74-6 Phenol, 4-nitro... | CAS号329722-31-8 5-Nitro-2-(oxir... | CAS号542-59-6 乙酸-2-羟基乙酯 | CAS号543-24-8 N-乙酰甘氨酸 | CAS号98-95-3 硝基苯

合成工艺路线路线简述

    乙酸苯酯置于ammonium Cerium(Iv) Nitrate体系中,化学反应 0.05H,以95%的收率获得产物4-硝基苯基乙酸酯
    参考文献:Ganguly,Nemai C.; Dutta,Sanjoy; Datta,Mrityunjoy,Journal Of Chemical Research,2005,# 11,P. 733-735
    标题:Ganguly,Nemai C.; Dutta,Sanjoy; Datta,Mrityunjoy,Journal Of Chemical Research,2005,# 11,P. 733-735

    海关参考信息

    专利信息


    专利号:US-6063919-A
    优先权日:1998-08-14
    标题:Process for the synthesis of exochelins
    发明人:GAUDIOSO LARRY A; WEGLARZ MICHAEL A
    权利人:KEYSTONE BIOMEDICAL INC
    摘要:A process for the synthesis of an Exochelin comprising the steps of generating L-N-[(2-benzyloxy-(benzoyl)] serine or L-N-[2-benzyloxy (benzoyl)] threonine, creating L-N-t-Boc- epsilon -hydroxynorleucine and reacting same to produce L-N-Boc- epsilon -bromonorleucine trimethylsilylethyl ester, providing a dicarboxylic acid and forming an O-benzyl methyl hydroxamate from the dicarboxylic acid, coupling the O-benzyl methyl hydroxamate with the L-N-Boc- epsilon -bromonorleucine trimethylsilylethyl ester to give an L-N2-Boc-N6-methyl,N6-(benzyloxy) lysine 2-trimethylsilylethyl ester which incorporates the dicarboxylic acid as modified above, removing the N-tert-butoxycarbonyl protecting group from the L-N2-Boc-N6-methyl, N6-(benzyloxy) lysine 2-trimethylsilylethyl ester to yield a substituted lysine, and coupling the same with the L-N-[2-benzyloxy (benzoyl) serine or -threonine to yield a 2-trimethyl silylethyl ester of dibenzyl Exochelic acid, transforming the 2-trimethyl silylethyl ester of dibenzyl Exochelic acid to dibenzyl Exochelic acid, preparing benzyl epi-cobactin, forming an ester bond between the dibenzyl Exochelic acid and benzyl epi-cobactin to form an intermediate, and, hydrogenolytically removing three benzyl groups from said intermediate, resulting in the synthesized Exochelin. More particularly, a synthesis for Exochelin 786SM (R) is disclosed wherein the dicarboxylic acid is suberic acid and the serine form is utilized.

    专利号:WO-2023118363-A1
    优先权日:2021-12-22
    标题:Method for the synthesis of a carbonyl-functionalised adduct
    发明人:GODEHARD SIMON P; PELZER ALEXANDER
    权利人:BRAIN Biotech AG
    摘要:The invention relates to a method for the synthesis of a carbonyl-functionalised adduct.

    专利号:US-2005119332-A1
    优先权日:1998-03-12
    标 题 :Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases)
    发明人:JEPPESEN LONE; ANDERSEN HENRIK S; OLSEN OLE H; JUDGE LUKE M; HOLSWORTH DANIEL D; BAKIR FARID; AXE FRANK U; GE YU
    摘要:The present invention provides novel compounds of formula 1a, n nnovel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

    专利号:US-10254287-B2
    优先权日:2015-07-21
    标题 :Protein fluorescent nanoparticles and methods of synthesis thereof
    发明人:KUMAR CHALLA VIJAYA; STROMER BOBBI SHANYELLE
    权利人:UNIV CONNECTICUT
    摘要:Disclosed herein are stable and versatile protein nanoparticles having a range of tunable fluorescent properties. Such nanoparticles may find utility in biological imaging. Methods of synthesis of such nanoparticles are also disclosed.

    专利号:WO-2024015528-A1
    优先权日:2022-07-15
    标题 :Efficient procedure for the synthesis of hydrazone-linked tetrahedral nanocages
    发明人:SCHNEEBELI SEVERIN; VESTRHEIM OLAV
    权利人:UNIV VERMONT
    摘要:The present application is directed to a nanocage of Formula (I): wherein A and R are as described herein. The present application is also directed to an efficient process for preparation of a nanocage of Formula (I), which allows for efficient scale-up of the nanocage synthesis. Furthermore, this new process allows for rapid nanocage diversification, due a newly introduced late-stage functionalization method.

    专利号:US-2009162290-A1
    优先权日:2005-09-09
    标 题 :Method for the synthesis of penta-pendant enantiomer-pure chelators and process for therapeutically active bioconjugates preparation by a covalent binding thereof
    发明人:BENES IVAN; CIHELNIK SIMON; DROZ LADISLAV; SRAMEK MARTIN
    权利人:THERAPHARM GMBH
    摘要:The present invention provides a method for synthesis and binding methods of pentapendant enantiomer-pure chelators of formula (VII) wherein R 1 , R 2 , R 3 , R 4 are groups forming an adequate enantiomer of the chelator; and X 1 -X 5 , Y 1 -Y 5 , Z 1 -Z 5 each individually forming pendant chelating groups.
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    [参考文献]: Amene Samaei-Nouroozi, Et Al. Medium-Based Optimization Of An Organic Solvent-Tolerant Extracellular Lipase From The Isolated Halophilic Alkalibacillus Salilacus. Extremophiles. 2015 Sep;19(5):933-47.
    [参考文献]: H Ando, Et Al. Antimicrobial Properties And Mechanism Of Volatile Isoamyl Acetate, A Main Flavour Component Of Japanese Sake (Ginjo-Shu). J Appl Microbiol. 2015 Apr;118(4):873-80.
    [参考文献]: Joanne L Porter, Et Al. Directed Evolution Of New And Improved Enzyme Functions Using An Evolutionary Intermediate And Multidirectional Search. Acs Chem Biol. 2015 Feb 20;10(2):611-21.
    [参考文献]: Marta Palusinska-Szysz, Et Al. Legionella Dumoffii Utilizes Exogenous Choline For Phosphatidylcholine Synthesis. Int J Mol Sci. 2014 May 9;15(5):8256-79.
    [参考文献]: Shiwen Zhuang#, Et Al. Production Of Medium-Chain Volatile Flavour Esters In Pichia Pastoris Whole-Cell Biocatalysts With Extracellular Expression Of Saccharomyces Cerevisiae Acyl-Coa:Ethanol O-Acyltransferase Eht1 Or Eeb1. Springerplus. 2015 Sep 2:4:467.

    合成参考文献


    参考文献:10.1016/j.jbiotec.2011.06.041
    摘要:Tang MC, Nisole A, Dupont C, Pelletier JN, Waldron KC. Chemical profiling of the deacetylase activity of acetyl xylan esterase A (AxeA) variants on chitooligosaccharides using hydrophilic interaction chromatography-mass spectrometry. J Biotechnol. 2011 Sep 10;155(2):257–65. doi: 10.1016/j.jbiotec.2011.06.041.
    参考文献:10.3389/fphar.2011.00034
    摘要:Supuran CT. Bacterial carbonic anhydrases as drug targets: toward novel antibiotics Front Pharmacol. 2011;2():34.
    参考文献:10.1007/s00253-011-3464-3
    摘要:Rehdorf J, Behrens GA, Nguyen GS, Kourist R, Bornscheuer UT. Pseudomonas putida esterase contains a GGG(A)X-motif confering activity for the kinetic resolution of tertiary alcohols. Appl Microbiol Biotechnol. 2012 Feb;93(3):1119–26. doi: 10.1007/s00253-011-3464-3.
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