CAS: 766-80-3; 1-(Bromomethyl)-3-Chlorobenzene

上下游产品

brom°Cyane (3-bromo-benzyl)-(3-chloro-benzyl)-methyl-amine (3-chloro-benzyl)-methyl-(4-nitro-benzyl)-amine 1-chloro-3-methylbenzene 1-(3-chloro-benzyl)-pyridinium; bromide 1-(3-chlorophenyl)-N,N-dimethylmethanamine 1-(3-chloro-benzyloxy)-2-methoxy-benzene (+/-)-3-(3-chloro-phenyl)-2-benzyl-propionic acid

间氯氯苄置于三正丁基氢锡,溴甲苯,过氧化苯甲酰体系中,用 乙腈 作为反应溶剂,化学反应 15.0H,反应生成 3-氯苄溴
参考文献:Polar Radicals. 14. Mechanism Of Trialkylstannane Reductions. Positive .Rho. Values For The Tri-N-Butylstannane Reduction Of Benzyl Halides. A Correlation With .Sigma.-
标题:Polar Radicals. 14. Mechanism Of Trialkylstannane Reductions. Positive .Rho. Values For The Tri-N-Butylstannane Reduction Of Benzyl Halides. A Correlation With .Sigma.-
摘要:
DOI:10.1021/ja00522A042

专利信息

专利号:WO-9943409-A1
优先权日:1998-02-27
标 题:Hplc fractionation of complex chemical mixtures
发明人：COOK PHILLIP DAN; CUMMINS LENDELL L; GRIFFEY RICHARD H; KAWASAKI ANDREW M; GAUS HANS; AN HAOYUN
权利人:ISIS PHARMACEUTICALS INC; COOK PHILLIP DAN; CUMMINS LENDELL L; GRIFFEY RICHARD H; KAWASAKI ANDREW M; GAUS HANS; AN HAOYUN
摘要:The rapid deconvolution of complex chemical mixtures, such as combinatorial libraries prepared via solution-phase simultaneous addition of functionalities is demonstrated using HPLC. Libraries containing 25-216 members were screened for biological activity and active libraries are fractionated into discreet pools using preferred reversed-phase HPLC. The entire process can be completed from a single synthesis of 15-50 mg, without the need for fixed positions, serial synthesis, or tagging.

专利号:US-6861523-B2
优先权日:2002-02-08
标 题 :1,3,5- trisubstituted-1,3,5-triazine-2,4,6-trione compounds and libraries
发明人：YU YONGPING; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TORREY PINES INST
摘要:The solid-phase synthesis of individual 1,3-disubstituted and 1,3,5-trisubstituted-1,3,5-triazine-2,4,6-triones and libraries thereof from a resin is described. Reaction of resin-bound amino acids with isocyanates yields resin-bound ureas, which further react with chlorocarbonyl isocyanate to selectively afford the resin-bound 1,3-disubstituted-1,3,5-triazine-2,4,6-triones. Selective alkylation at the N-5 position of the resin-bound 1,3-disubstituted-1,3,5-triazine-2,4,6-triones produces a trisubstituted triazinetrione. The products are cleaved from their solid support and obtained in good yield and purity.

专利号:US-5081138-A
优先权日:1986-12-17
标题:3-hetero-substituted-n-benzyl-indoles and prevention of leucotriene synthesis therewith
发明人：GILLARD JOHN W; MORTON HOWARD E; FORTIN REJEAN; GUINDON YVAN
权利人:MERCK FROSST CANADA INC
摘要:Compounds having the formula: are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.

专利号:US-12410142-B2
优先权日:2017-04-07
标 题:Substituted imidazole salt compounds, preparation method thereof, pharmaceutical composition thereof and application thereof
发明人：DENG XIANMING; LIN SHENGCAI; ZHANG CHENSONG
权利人:XIAMEN VIVOHEALTHS TECH CO LTD
摘要:Disclosed in the invention are a type of compounds having aldolase selective inhibitory activity, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for inhibiting triglyceride and cholesterol synthesis, for reducing fatty acid synthesis, for preventing and/or treating obesity and type II diabetes, for preventing and/or treating tumor, for preventing and/or treating Parkinson's disease, for preventing and/or treating Alzheimer's disease or for prolonging the lifespan of mammals:

专利号:US-7709678-B2
优先权日:2003-10-24
标题:Method for producing asymmetric alkyl compound using alkali-treated solid support, and alkali-treated solid support used in this method
发明人：KOSHIMA HIDEKO; YU HAITAO
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:An asymmetric alkyl compound producing method of the present invention includes a synthesizing step of carrying out an asymmetric synthesis reaction by mixing (i) a reaction solution containing a glycine imine ester, an alkyl halide, and an asymmetric catalyst having a catalytic action which causes the asymmetric synthesis reaction to proceed with (ii) an alkali-treated solid support obtained by treating with an alkaline substance a solid support made of an inorganic compound. By placing this mixture at room temperature, the asymmetric alkylation occurs between the glycine imine ester and the alkyl halide which are catalyzed by the asymmetric catalyst in an alkali-treated solid support contained in the mixture, and the asymmetric alkylation is completed in about 1 hour. Thus, a highly optically pure asymmetric alkyl compound can be obtained in high yield. Therefore, it is possible to provide the asymmetric alkyl compound producing method which does not require the agitation of the solvent, completes the asymmetric alkylation efficiently and stably in a short time, and synthesizes a highly optically pure asymmetric alkyl compound in high yield.

专利号:US-9896479-B2
优先权日:2012-05-16
标 题 :Functionalized naphthalene fluorophores
发明人：BRUMMOND KAY M; KOCSIS LAURA S; BENEDETTI ERICA
权利人:BRUMMOND KAY M; KAY M BRUMMOND
摘要:Methods for the synthesis and use of functionalized, substituted naphthalenes are described. The functionalized, substituted naphthalenes display useful properties including liquid crystals and fluorescence properties, such as solvatochromatic fluorescence, with high quantum yields, Stoke's shift, and show emission maxima that are significantly red-shifted.