CAS: 728-88-1; 2-Methyl-3-(Piperidin-1-yl)-1-(P-Tolyl)Propan-1-One

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CAS号122-00-9 对甲基苯乙酮 | CAS号110-89-4 六氢吡啶 | CAS号1023-20-7 4'-Methyl-3-(1-...

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    📜托哌酮杂质4置于palladium On Activated Charcoal 氢氧化钾,氢气体系中,用 乙醇,水,溶剂黄146 作为反应溶剂,化学反应 8.0H,反应生成 托哌酮
    参考文献:Synthesis Of3H-Tolperisone
    标题:Synthesis Of3H-Tolperisone
    摘要:Tolperisone (2) Has Been Tritiated To 50 Ci/mmol Specific Activity In Order To Use This Compound In The Study Of Muscle Relaxant Binding. Of The Two Reaction Pathways Investigated,Hydrogenolytic Exchange Of Aromatic Bromine Is Favored Over Hydrogenation Of A Double Bond.
    DOI:10.1002/(Sici)1099-1344(199912)42:12<1125::Aid-Jlcr266>3.0.Co;2-9

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    专利号:CN-109180606-A
    优先权日:2018-09-30
    标 题 :Synthesis of a class of optically active β-amino ketones

    专利号:DE-10206405-A1
    优先权日:2002-02-14
    标题 :Synthesis of substituted carbamide esters

    专利号:CN-119241531-A
    优先权日:2024-11-08
    标题 :Synthesis process of 6-hydroxy tropinone

    专利号:CN-119241531-B
    优先权日:2024-11-08
    标题:A kind of synthesis process of 6-hydroxytropinone

    专利号:CN-114214648-B
    优先权日:2022-01-10
    标题 :A kind of electrochemical synthesis method for preparing 1,1,4,4-tetramethoxy-2-butene

    专利号:CN-117050020-A
    优先权日:2023-05-30
    标 题:A kind of synthesis method of pyridazine

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    主要参考文献


    1: Luo D, Wu G, Ji Y, Zhang Z, He F, Mou X, Zhu Q, Yang B. The comparative study of clinical efficacy and safety of baclofen vs tolperisone in spasticity caused by spinal cord injury. Saudi Pharm J. 2017 May;25(4):655-659. doi: 10.1016/j.jsps.2017.04.041. Epub 2017 May 7.
    2: Agarwal S, Patel T, Shah N, Patel BM. Comparative study of therapeutic response to baclofen vs tolperisone in spasticity. Biomed Pharmacother. 2017 Mar;87:628-635. doi: 10.1016/j.biopha.2017.01.005. Epub 2017 Jan 10. Erratum in: Biomed Pharmacother. 2017 Aug;92:1140. doi: 10.2174/1874104501408010017. eCollection 2014.

    合成参考文献


    参考文献:10.1007/s00586-005-1048-6
    摘要:van Tulder MW, Koes B, Malmivaara A. Outcome of non-invasive treatment modalities on back pain: an evidence-based review. European Spine Journal. 2005 Dec 01;15(Suppl 1):s64–81. doi: 10.1007/s00586-005-1048-6.
    摘要:Prabhoo R, Keny S, Prabhoo T, Singh A, Rana R. A phase IV observational multi-centre, open-label study on efficacy and safety of tolperisone 150 mg in patients with painful muscle spasm associated with degenerative or inflammatory diseases of the musculoskeletal system. J Assoc Physicians India. 2011 Jan;59():33–7.
    参考文献:10.1107/s1600536811007513
    摘要:Maharramov AM, Khalilov AN, Gurbanov AV, Allahverdiyev MA, Ng SW. 1-Methyl-amino-3-(2,4,6-trimethyl-phen-yl)propan-2-ol. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):o784.
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