CAS: 709031-78-7; (1S,3S,5S)-2-((2S)-2-Amino-2-(3-Hydroxyadamantan-1-yl)Acetyl)-2-Azabicyclo[3.1.0]Hexane-3-Carbonitrile Hydrochloride

该化合物是用于管理2型糖尿病血清4(DPP-4)的有选择性的强效低脂基脂基聚酯抑制剂,其功能是增强内分泌性激素活动,从而增加胰岛素分泌,并以依赖葡萄糖的方式降低甘油水平.盐盐形式确保改善溶解性和生物利用率,促进持续的药用动力性性能.盐酸盐对DPP-4具有高度的特性,最大限度地减少离目标效果,并展示一种有利于安全且低血清风险的有利安全特征.其一次剂量系统可以加强患者的合规性.该化合物在严格的质量控制下合成,以达到药用标准,确保治疗应用的可靠性.

英文名称(1S,3S,5S)-2-((2S)-2-Amino-2-(3-Hydroxyadamantan-1-yl)Acetyl)-2-Azabicyclo[3.1.0]Hexane-3-Carbonitrile Hydrochloride
中文名称盐酸沙格列汀
IUPAC名称(1S,3S,5S)-2-((2S)-2-amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride
其它别名(1S,3S,5S)-2-[(2S)-Amino(3-Hydroxytricyclo[3.3.1.13,7]Dec-1-yl)Acetyl]-2-Azabicyclo[3.1.0]Hexane-3-Carbonitrile Hydrochloride; C18H26Cln3O2; Z8J84Yix6L; Saxagliptin Hcl; Tuaznhhhyvbvbr-Nhkadlrusa-N; Saxagliptin Hydrochloride
CAS编号709031-78-7
MFCD编号:MFCD22572334
EINECS号:696-124-3
FDA UNII编号:Z8J84YIX6L
分子式:C18H26ClN3O2
分子量:351.88
产品CID: 1703270
同类组份化合物CAS945667-22-1 (hydrate)709031-78-7 (HCl)361442-04-8 (free base)1073057-20-1 (HCl hydrate)1073057-33-6 (benzoate hydrate)
产品分类生物化工 → 生化试剂 → 激动剂抑制剂

相似结构搜索
InChIKey: TUAZNHHHYVBVBR-NHKADLRUSA-N
TUAZNHHHYVBVBR-PMEPUXBANA-N…
计算化学: 氢键受体数4.0氢键供体数3.0可旋转键数2.0

MSDS等安全信息

GHS象形图
GHS符号GHS08 & GHS07;
注释: Health hazard & Exclamation mark
危险类别致癌性类别2
生殖毒性类别2
特定目标器官毒性 - 单次接触类别3
特定目标器官毒性-重复接触类别1
皮肤致敏类别1B
警示词Danger(危险)
危险描述H351 |怀疑致癌.
H361 |怀疑对生育能力或胎儿造成损害.
H335 |可能引起呼吸道刺激.
H372 |长期或反复接触损害器官.
H317 |可能引起皮肤过敏反应.
防范说明P260-P264-P270-P314-P501-P201-P202-P281-P308+P313-P405-P501-P201-P202-P281-P308+P313-P405-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
安全声明H317 (100%)H335 (100%)H351 (100%)

欧盟法规

C&L通报

合成工艺路线路线简述

(1S,3S,5S)-2-[(2S)-2-Propan-2-Ylideneamino-2-(3-Hydroxy-1-Adamantyl)Acetyl]-2-Azabicyclo[3.1.0]-Hexane-3-Carbonitrile置于氯化铵体系中,化学反应生成盐酸沙格列汀
参考文献:Polymorphs Of Saxagliptin Hydrochloride And Processes For Preparing Them
标题:Polymorphs Of Saxagliptin Hydrochloride And Processes For Preparing Them
摘要:本发明提供了萨格列普汀盐酸盐的多形态,制备萨格列普汀盐酸盐的多形态的方法,以及萨格列普汀盐酸盐的多形态的药物组合物.

海关参考信息

2905122000-异丙醇
2905143000-叔丁醇
2912110000-甲醛
2912120000-乙醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-9150511-B2
优先权日:2011-05-24
标题 :Process for preparing saxagliptin and its novel intermediates useful in the synthesis thereof
发明人：KOVI RAVISHANKER; RAPOLE KESHAVRAO; NAIK ASHISH; KANNAPAN JAYARAMAN; MADALA MURALIKRISHNA; THAKOR SANJAY
权利人:APICORE US LLC
摘要:Methods of making saxagliptin, pharmaceutically acceptable salts and hydrates thereof and intermediates thereof.

专利号:CN-115894207-B
优先权日:2022-12-08
标题:Synthesis method of 2- (3-hydroxy-1-adamantane) -2-oxo acetic acid

其他信息查阅

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主要参考文献

1: Leiter LA, Teoh H, Braunwald E, Mosenzon O, Cahn A, Kumar KM, Smahelova A, Hirshberg B, Stahre C, Frederich R, Bonnici F, Scirica BM, Bhatt DL, Raz I; SAVOR-TIMI 53 Steering Committee and Investigators. Efficacy and safety of saxagliptin in older participants in the SAVOR-TIMI 53 trial. Diabetes Care. 2015 Jun;38(6):1145-53. doi: 10.2337/dc14-2868. Epub 2015 Mar 10. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med. 2013 Oct 3;369(14):1317-26. doi: 10.1056/NEJMoa1307684. Epub 2013 Sep 2. doi: 10.1111/dom.12461. Epub 2015 Apr 7. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes and moderate or severe renal impairment: observations from the SAVOR-TIMI 53 Trial. Diabetes Care. 2015 Apr;38(4):696-705. doi: 10.2337/dc14-1850. Epub 2014 Dec 31. doi: 10.1007/s12325-015-0262-9. Epub 2015 Nov 17. Review.
6: Mathieu C, Ranetti AE, Li D, Ekholm E, Cook W, Hirshberg B, Chen H, Hansen L, Iqbal N. Randomized, Double-Blind, Phase 3 Trial of Triple Therapy With Dapagliflozin Add-on to Saxagliptin Plus Metformin in Type 2 Diabetes. Diabetes Care. 2015 Nov;38(11):2009-17. doi: 10.2337/dc15-0779. Epub 2015 Aug 5. doi: 10.2337/dc14-1142. Epub 2014 Oct 28. doi: 10.1002/prp2.201. eCollection 2015 Dec.
9: Sakai M, Uchii M, Myojo K, Kitayama T, Kunori S. Critical role of renal dipeptidyl peptidase-4 in ameliorating kidney injury induced by saxagliptin in Dahl salt-sensitive hypertensive rats. Eur J Pharmacol. 2015 Aug 15;761:109-15. doi: 10.1016/j.ejphar.2015.04.023. Epub 2015 May 1. doi: 10.2337/dc15-0811. Epub 2015 Aug 31. doi: 10.1186/s40360-015-0007-z.

合成参考文献

参考文献:10.1186/s43094-024-00658-6
摘要:Mehta M, Mehta D, Mashru R. Recent application of green analytical chemistry: eco-friendly approaches for pharmaceutical analysis. Futur J Pharm Sci. 2024 Jul 08;10(1). doi: 10.1186/s43094-024-00658-6.