4-甲氧基-3-甲基苄醇置于盐酸,乙醚体系中,化学反应生成 2,4-二甲基-1-甲氧基苯 参考文献:Quelet; Allard,Bulletin De La Societe Chimique De France,1937,Vol. <5> 4,P. 1468,1470 标题:Quelet; Allard,Bulletin De La Societe Chimique De France,1937,Vol. <5> 4,P. 1468,1470
专利号:US-7678877-B2 优先权日:2004-12-03 标题 :Process for the synthesis of polyalkylphenol antioxidants 发明人:YANG SUIZHOU; CHOLLI ASHOK L 权利人:POLNOX CORP 摘要:Disclosed is a method for the synthesis of sterically hindered polymeric antioxidants based on phenol type antioxidant monomers. The method includes partially etherifying, polymerizing and thermally rearranging a phenol containing monomer represented by the following structural formula: n nto produce a sterically hindered polymeric macromolecular antioxidant. X, R 10 and q are as defined herein. The disclosed method is a simple, direct and economical process for the synthesis of sterically hindered polymeric macromolecular antioxidants.
专利号:US-9802952-B2 优先权日:2013-07-15 标 题:Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives 发明人:KOPETZKI DANIEL; MCQUADE DAVID TYLER; SEEBERGER PETER H; GILMORE KERRY 权利人:MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V; MAX-PLANK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V 摘要:The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C 1 -C 5 alcohol.
专利号:US-2006128929-A1 优先权日:2004-12-03 标 题:Process for the synthesis of polyalkylphenol antioxidants
专利号:US-2016145265-A1 优先权日:2013-07-15 标题:Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives
专利号:US-9555039-B2 优先权日:2011-05-09 标题:Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT) 发明人:BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; KUNTZ JUDITH D; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG 权利人:BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; KUNTZ JUDITH D; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC 摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below: Formula (I)
专利号:US-8372971-B2 优先权日:2004-08-25 标 题:Heterocyclic compounds and methods of use 发明人:WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA 权利人:TARGEGEN INC; WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA 摘要:Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.