专利号:US-6350878-B1 优先权日:1998-05-18 标 题 :Intermediates for the synthesis of epothilones and methods for their preparation 发明人:ALTMANN KARL-HEINZ; BAUER ARMIN; SCHINZER DIETER 权利人:NOVARTIS AG 摘要:The invention relates to a method of synthesis for a compound of formula (I),wherein R is a heterocyclyl moiety and X1, X2, X3 and X4 are, independently of each other, protecting groups, which is appropriate for the synthesis of epothilone B and desoxyepothione B.
专利号:US-2010069644-A1 优先权日:2008-09-15 标题:Method of regio-selective synthesis of tri-substituted-1, 2, 3-triazoles 发明人:SHI XIAODONG 权利人:SHI XIAODONG 摘要:The embodiments provide for region-selective synthesis of tri-substituted 1,2,3-traizoles. A first embodiment provides for the selective N-2 alkylation of a 4,5-disubstituted 1,2,3-triazole. A second embodiment provides for the selective acetylation of a 4,5-disubstituted 1,2,3-triazole. A third embodiment provides for the selective arylation of a 4,5-disubstituted 1,2,3-triazole.
专利号:US-2023002312-A1 优先权日:2019-11-20 标题:A continuous flow process for the synthesis of hydroxamic acid 发明人:PIMPALE MILIND JAGANNATH; KINI PRASHANT VASANT 权利人:UPL LTD 摘要:The present invention relates to a process for the synthesis of hydroxamic acids by continuous flow process wherein said process comprising reacting alkyl ester with hydroxyl amine salt in presence of base in a microreactor system and continuously producing hydroxamic acid.
专利号:US-8742028-B2 优先权日:2009-05-06 标 题:Solid support for Fmoc-solid phase synthesis of peptide acids 发明人:SRIVASTAVA KRIPA S; DAVIS MATTHEW R 权利人:SRIVASTAVA KRIPA S; DAVIS MATTHEW R; MALLINCKRODT LLC 摘要:The present invention provides a solid support for Fmoc-solid phase synthesis of peptides. In particular, the solid supports of the invention may be utilized to produce peptide acids.
专利号:US-4284582-A 优先权日:1978-04-28 标 题 :Process for the preparation of cyclopropane derivatives, intermediates in the synthesis of pyrethroid insecticides 发明人:KAYE ALBERT E; TUCKER ALAN C 权利人:ICI LTD 摘要:Compounds of formula: wherein both groups X are chlorine, bromine or trifluoromethyl, or one X is chlorine or bromine and the other is trifluoromethyl, and Y is -CN or -COOR in which R is an alkyl group, are obtained by (A) reacting a compound of the formula: wherein X1 is chlorine or bromine, with a compound of the formula: X2C=CH-CH=C(CH3)2 in the presence of metallic copper or at least one copper salt and a base, or (B) reacting a compound of the formula: Y-CH2-CN with a compound of the formula: X2C=CH-CH=C(CH3)2 and chlorine or bromine, in the presence of at least one reducible copper salt and a base, or (C) reacting a compound of formula: X-CH2-CN with a compound of the formula: wherein X1 is chlorine or bromine, in the presence of at least one copper salt. The compounds are intermediates in the synthesis of pyrethroid insecticides.
专利号:US-8420848-B2 优先权日:2009-01-09 标题:Process for the synthesis of beta glycerol phosphate 发明人:KULKARNI YASHWANT 权利人:KULKARNI YASHWANT; SIGMA ALDRICH CO LLC 摘要:The present invention provides methods for the preparation of beta glycerol phosphate and its salts. In particular, the invention provides efficient methods for the synthesis of beta glycerol phosphate of high purity.
摘要:Shi, Y.; Cole-Hamilton, D. J.; Kamer, P. C. J., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2017) 2, 192. 参考文献:10.1007/bf00925512 摘要:Meuleman EA, Holzmann PJ, Peet RC. The development of daughter sporocysts inside the mother sporocyst ofSchistosoma mansoni with special reference to the ultrastructure of the body wall. Zeitschrift für Parasitenkunde Parasitology Research. 1980 Oct;61(3):201–12. doi: 10.1007/bf00925512. 摘要:National Technical Information Service., OTS0556694 摘要:National Technical Information Service., OTS0558878 摘要:49 CFR 171.2; U.S. National Archives and Records Administration's Electronic Code of Federal Regulations. Available from, as of November 22, 2011: https://www.ecfr.gov