CAS: 61318-91-0; Sulconazole Nitrate

该化合物是一种属于imidazole类的抗冻剂,主要用于治疗皮肤纤维素和直肠丝虫,其化学结构具有硝酸盐溶性,溶性增强和生物利用率的特征.该化合物展示了抗病原菌的广谱性活动,包括三氯磷素,微粒子和Candida物种,通过细胞化P450-依赖性14α-demothyase干扰来抑制egosterol生物合成物.关键优势包括低浓度的强效真菌和真菌效应,以及时态制剂的稳定性. 硫化甲酸单硝酸酯展示了极有利的皮肤渗透,同时尽量减少系统性吸收,减少了不良效应的风险. 它在急性和慢性肿瘤感染中的功效使得它在皮肤治疗中成为可靠的选择.

结构式图片

欧盟法规

C&L通报

上下游产品

CAS号46503-49-5 1-(2-氯-2-(2,4-二... | CAS号6258-66-8 4-氯苄硫醇

合成工艺路线路线简述

  • 合成目标产物 Sulconazole Nitrate 主要起始原料 1-(2-Chloro-2-(2,4-Dichlorophenyl)Ethyl)-1H-Imidazole And 4-Chlorobenzyl Mercaptan
  • (文献来源)合成步骤主要原料 1-(2-Chloro-2-(2,4-Dichlorophenyl)Ethyl)-1H-Imidazole 和 4-Chlorobenzyl Mercaptan
Alpha-(2,4-二氯苯基)-1H-咪唑-1-乙醇置于三乙胺,Sodium Hydroxide体系中,用 甲醇,水,甲苯 作为反应溶剂,化学反应 4.0H,反应生成 硝酸硫康唑
参考文献:Cn116063234
标题:Cn116063234

海关参考信息

专利信息


专利号:US-8557979-B2
优先权日:2004-06-10
标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation
发明人:CHOI WOO-BAEG; KOWALIK EWA
权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC
摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

专利号:US-10933051-B2
优先权日:2017-06-09
标 题 :Carbapenem compounds and compositions for the treatment of bacterial infections
发明人:CHOI WOO-BAEG; TOMIOKA TAKASHI; JOO HYUNG-YEUL; TRUONG PHONG; MIN BRIAN
权利人:FOB SYNTHESIS INC
摘要:The present invention provides carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections, including drug resistant or multiple-drug resistant bacterial infections, and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

专利号:US-9937151-B2
优先权日:2010-06-18
标题 :Carbapenem antibacterials with gram-negative activity
发明人:CHOI WOO-BAEG; GRUSZECKA-KOWALIK EWA; JOO HYUNG-YEUL; LIU SHUANGPEI; MAO SHULI; LI YONGFENG; KIM DEOG-IL
权利人:FOB SYNTHESIS INC
摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

专利号:US-8361516-B2
优先权日:2006-08-03
标 题:Composition comprising sarsasapogenin
发明人:LINTNER KARL; MAS CHAMBERLIN CLAIRE
权利人:SEDERMA SA; LINTNER KARL; MAS CHAMBERLIN CLAIRE
摘要:The présent invention relates to a composition comprising sarsasapogenin or a plant extract containing it in order to improve the gêneral state of the skin and in particular to improve and/or embellish any part of the body showing a déficit in lipids. More particularly, the invention is directed to a cosmetic method to improve the figure, comprising the step of topically applying to the skin a cosmetic or dermopharmaceutical composition comprising sarsasapogenin to favour the expansion and/or the formation of the subcutaneous adipose tissue, and/or to favour the lipid synthesis in the epidermis.

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.
山东科源制药股份有限公司
⚠️ 未注册 · 未认证企业
⚠️ 该商家尚未完成注册及企业认证,请用户仔细辨别,谨慎交易。
数据来源于公开网络搜索,平台未作核实,请自行辨别。
🏢敬请 企业认领
🏬开设公司展台
📢获取免费会员权益
🎖️点亮专属注册企业标签
📇展现公司完整信息 样本查看立即注册认领 →
网址: http://www.keyuanpharm.com
电话: 0531-84779610👤
📞山东科源制药股份有限公司 ⚠️参考联系方式

销售电话:0531-84779610
邮箱:public@keyuanpharm.com
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领,请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实,百琢研不参与任何交易。企业认领注册入口→

⚠️ 未注册 · 未认证企业
注册入口 备注: 📌 数据来源说明:本展台内容基于各搜索引擎等公开数据整理,仅作展示用途。请用户自行辨别 ✉️ 若企业需抹除展台内容或有异议, 请通过页面底部联系方式告知我们,我们会尽快处理。
第 1 / 1 页
现货

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献


1: Azari F, Kennedy GT, Chang A, Nadeem B, Bou-Samra P, Chang A, Segil A, Bernstein E, Sullivan NT, Eruslanov E, Delikatny J, Singhal S. Sodium Multivitamin Transporter-Targeted Fluorochrome Facilitates Enhanced Metabolic Evaluation of Tumors Through Coenzyme-R Dependent Intracellular Signaling Pathways. Mol Imaging Biol. 2023 Jun;25(3):569-585. doi: 10.1007/s11307-022-01792-4. Epub 2022 Dec 19.
2: Payyal SP, Rompicherla NC, Sathyanarayana SD, Shriram RG, Vadakkepushpakath AN. Microemulsion Based Gel of Sulconazole Nitrate for Topical Application. Turk J Pharm Sci. 2020 Jun;17(3):259-264. doi: 10.4274/tjps.galenos.2019.75537. Epub 2020 Jun 22.
3: Xu Q, Khan A, Gao D, Adams KM, Tadjimukhamedov F, Tan S, Simpson JT. Structural confirmation of sulconazole sulfoxide as the primary degradation product of sulconazole nitrate. J Pharm Anal. 2018 Apr;8(2):96-102. doi: 10.1016/j.jpha.2017.12.007. Epub 2017 Dec 19.

合成参考文献


摘要:Iyakuhin Kenkyu. Study of Medical Supplies., 17(365), 1986
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知