CAS: 60233-24-1; 2,3',4,6-Tetrachlorobiphenyl
该化合物是多氯联苯(PCB)家族的成员,这些合成有机化学品由多氯原子组成的双联苯组成,该化合物在联苯结构上,特别是2,3',4和6位置上,有四个氯原子替代物,在2,3',4,6-四氯联苯,在室温下无色至浅黄色固体,具有低挥发性,高热稳定性.2,3',4,6-四氯联苯是缺水的,这意味着水溶性低,但可溶解于有机溶剂,众所周知,该化合物在环境中具有持久性,在活生物体中具有潜在的生物累积性,引起人们对其生态和健康影响的关切,已对其毒性影响进行了研究,包括内分泌干扰和潜在致癌性.由于其环境持久性和毒性,包括2,2,4,4,6-四氯联苯的使用在许多国家受到严格管制或禁止.
- 英文名称2,3',4,6-Tetrachlorobiphenyl
- 中文名称2,3',4,6-四氯联苯
- IUPAC名称1,3,5-trichloro-2-(3-chlorophenyl)benzene
- 其它别名2,3',4,6-Tetrachlorobiphenyl; 3,2',4',6'-Tetrachlorobiphenyl; PCB 69
- CAS编号60233-24-1
- MFCD编号:MFCD00152847
- FDA UNII编号:54M5KB6113
- 分子式:C12H6Cl4分子量:291.99
- 产品CID: 1578912
- 产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: CKUBKYSLNCKBOI-UHFFFAOYSA-N
- InChI=1S/C12H6Cl4/c13-8-3-1-2-7(4-8)12-10(15)5-9(14)6-11(12)16/h1-6H
- 计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0
物理性质
MSDS等安全信息
- 危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website. - 安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)
上下游产品
chlorobenzene 2,4,6-trichloroaniline 1,3,5-trichloro-2-iodobenzene 3-chlorophenylboronic acid合成工艺路线路线简述
📜氯苯,2,4,6-三氯苯胺置于sodium Acetate,亚硝酸体系中,化学反应生成 2,3',4,6-四氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4
海关参考信息
- 2903919090-氯苯
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Synthesis Of Polychlorinated Biphenyls And Their Metabolites With A Modified Suzuki-Coupling作者:Izabela Kania-Korwel,Sean Parkin,Larry W Robertson,Hans-Joachim Lehmler |发布日期:2004.8
摘要:A Modified Procedure For The Synthesis Of Polychlorinated Biphenyls (Pcbs) Utilizing The Suzuki-Coupling, A Palladium-Catalyzed Cross-Coupling Reaction, Is Described. The Coupling Of (Chlorinated) Benzene Boronic Acids With Bromochlorobenzenes, Using Pd(Dppf)(2)Cl(2) (Dppf = 1,1'-Bis(Diphenylphosphino)Ferrocene) As The Catalyst And Aqueous Sodium Carbonate As The Base, Gave The Desired Pcb Congeners
合成参考文献
摘要:T14: Lewis RJ (1996). Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold.
摘要:L4: ATSDR - Agency for Toxic Substances and Disease Registry (2000). Toxicological profile for polychlorinated biphenyls. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
摘要:L134: ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
摘要:L135: International Agency for Research on Cancer (2014). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
摘要:T6: World Health Organization (1993). Environ Health Criteria 140: Polychlorniated Biphenyls and Terphenyls.
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