CAS: 55405-67-9; 3-Bromopyrazolo[1,5-A]Pyrimidine

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上下游产品

CAS号16461-94-2 3-氨基-4-溴吡唑 | CAS号102-52-3 1,1,3,3-四甲氧基丙烷 | CAS号1169690-88-3 3-(4,4,5,5-四甲基-...

📜吡唑并[2,3-A]嘧啶置于碘苯二乙酸,Potassium Bromide体系中,用 水 作为反应溶剂,以81 %的收率获得产物3-溴吡唑[1,5-A]嘧啶
参考文献:高价碘(Iii)在水相和环境条件下促进吡唑并[1,5-A]嘧啶的区域选择性c(Sp2)-h卤化
标题:高价碘(Iii)在水相和环境条件下促进吡唑并[1,5-A]嘧啶的区域选择性c(Sp2)-h卤化
摘要:开发了一种有效且温和的方法,使用易于获得的卤化钾盐和高价碘(Iii)试剂在环境温度下对吡唑并[1,5-A]嘧啶进行区域选择性直接c3卤化.该方案既实用又环保,利用水作为绿色溶剂,卤化钾作为廉价且稳定的卤素源,Pida作为无毒试剂,可在室温下实现清洁高效的卤化.该程序以非常好至优异的产率产生一系列 C3 卤代吡唑并[1,5-A]嘧啶.机理研究表明亲电取代机制参与卤化过程.
DOI:10.1039/d4Ra02090A

专利信息

专利号:WO-2024108957-A1
优先权日:2022-11-23
标题 :5-cyanopyrazolo[1,5-a]pyrimidine compound and synthesis method therefor
发明人：MA SHITANG; Qu Hengtong; XU QILIN; SUN CHAOYUE; CHEN NAIDONG
权利人:UNIV WEST ANHUI
摘要:Disclosed is a 5-cyanopyrazolo[1,5-a]pyrimidine compound represented by formula III, wherein R1 is hydrogen, chlorine, bromine, a cyano, a carboxyethoxy, a methyl, an isopropyl, a tert-butyl, a cyclopropyl, an isopropoxy, a phenyl, a 4-fluorophenyl, a 4-chlorophenyl, a 4-methylphenyl, a 4-methoxyphenyl, or a 3-methoxyphenyl, and R2 is a phenyl, a 4-fluorophenyl, a 4-chlorophenyl, a 4-bromophenyl, a 4-methylphenyl, a 4-dimethylaminophenyl, or a furyl. Further disclosed is a method for synthesizing a 5-cyanopyrazolo[1,5-a]pyrimidine compound. The method comprises: mixing a 3-aminopyrazole compound, a cinnamaldehyde derivative, a trimethylsilyl cyanide, a catalyst, a ligand, and a reaction solvent, and reacting same in the presence of oxygen, so as to obtain a 5-cyanopyrazolo[1,5-a]pyrimidine compound.