📜3-甲基噻吩置于乙醇,磷酸,Raney Nickel W-2,三氟乙酸酐体系中,用 乙腈 作为反应溶剂,化学反应生成 (+/-)-麝香酮 参考文献:Ring-Closure Reactions. 16. An Improved Procedure For The Synthesis Of (2,5)Thiophenophan-1-Ones And Its Application To A Convenient Preparation Of Dl-Muscone 标题:Ring-Closure Reactions. 16. An Improved Procedure For The Synthesis Of (2,5)Thiophenophan-1-Ones And Its Application To A Convenient Preparation Of Dl-Muscone 摘要: DOI:10.1021/jo01298A029
专利号:US-5936100-A 优先权日:1996-12-16 标 题:Synthesis of functionalized macrocycles by ring closing metathesis 发明人:FUERSTNER ALOIS; LANGEMANN KLAUS; KINDLER NICOLE 权利人:STUDIENGESELLSCHAFT KOHLE MBH 摘要:The invention concerns an improved process for the preparation of macrocyclic products with 12 or more ring atoms containing one or more polar functional groups on the ring and/or one or more heteroatoms within the ring by ring closing metathesis (RCM) of suitably substituted diene precursors even if the substrates are devoid of any kind of conformational preorganization. Metal carbene complexes of Ru, Mo, W, Re, Os, which are tolerant towards the respective functional group and can either be isolated or prepared in situ are used as catalysts or catalyst precursors. Preferred catalysts or catalyst precursors are ruthenium complexes of the general type XX1LL1Ru=CRR1, wherein X, X1=halogen, L, L1=trialkylphosphine, R, R1=H, Ph, CH=CPh2 denote the most preferred embodiment. The process can be applied to the synthesis of olfactory compounds, perfumary ingredients, pheromones, crown ethers, antibiotics and pharmaceuticals for human and veterinary medicine.
专利号:US-2014296354-A1 优先权日:2013-04-01 标题 :Synthesis of peptoid-based small molecular gelators from multiple component reactions 发明人:WANG GUIJUN; MANGUNURU HARI P R 权利人:WANG GUIJUN; MANGUNURU HARI P R; OLD DOMINION UNIV RES FOUND 摘要:Described herein are the one-pot synthesis and characterization of a library of low molecular weight peptoid compounds that are able to form gels at room temperature. The compounds are synthesized from biologically-based starting materials, are biocompatible, and are resistant to degradation by proteases and peptidases. The compounds and gels synthesized therefrom can be used in such applications as tissue engineering, drug delivery, separation of biomolecules, and stimulus-responsive advanced materials
专利号:WO-2020121017-A1 优先权日:2018-12-09 标题 :Cream synthesis from platelet mediators with herbal penetration enhancers to increase the skin's collagen 发明人:AFRASIABIAN HAMIDOLLAH 权利人:AFRASIABIAN HAMIDOLLAH 摘要:This invention using complementary medicine to the synthesis of anti-aging cream which is effective, non-invasive and based on scientific principles. So, we used platelet mediators which are approved by FDA and the safe herbal penetrators with many useful properties. For the first time, the musk has been used as an effective penetration enhancer in the formulation with unexpected positive effects. The randomized clinical trial showed the final product will help the skin rejuvenation.
专利号:US-11753417-B2 优先权日:2019-01-17 标 题 :Synthesis of 14-methyl-16-oxabicyclo[10.3.1]hexadec-12-ene 发明人:GARA MOHAMAD; BECKER YIGAL 权利人:INT FLAVORS & FRAGRANCES INC 摘要:Disclosed is a scalable process for preparation of 14-methyl-16-oxabicyclo[10.3.1]hexadec-12-ene (BCE), a key intermediate for manufacture of fragrance ingredient 3-methylcyclopentadecenone (MUSCENONE®) and analogs through reaction of 3-Methyl-1,5-cyclopentadecanedione (MCPD) and analogs with a metal or metalloid alkoxide in high yield and purity.
专利号:US-4296258-A 优先权日:1979-01-26 标 题:Process for the preparation of macrocyclic ketones 发明人:FEHR CHARLES; OHLOFF GUENTHER; BUECHI GEORGES H 权利人:FIRMENICH & CIE 摘要:New process for the preparation of acetylenic macrocyclic ketones, which compounds represent useful intermediates for the synthesis of valuable perfuming ingredients, viz. muscone and EXALTONE® (cyclopentadecanone).
专利号:CN-101239895-B 优先权日:2008-02-20 标 题 :(4R)-4-Methyl-15-enyl-6-hexadecanone derivatives, synthesis method and its use in the synthesis of muskone
1: Wang GY, Wang N, Liao HN. Effects of Muscone on the Expression of P-gp, MMP-9 on Blood-Brain Barrier Model In Vitro. Cell Mol Neurobiol. 2015 Nov;35(8):1105-15. doi: 10.1007/s10571-015-0204-8. Epub 2015 May 15. doi: 10.3892/ijmm.2014.1766. Epub 2014 May 2. 3: Chen ZZ, Du SY, Lu Y, Xu P, Yang B, Liu HM. [Mechanism research of aromatics borneol and muscone]. Zhong Yao Cai. 2014 Mar;37(3):460-4. Chinese. doi: 10.1080/10286020.2014.996141. Epub 2015 Jan 6. doi: 10.1055/s-0035-1565264. Epub 2015 Oct 16. doi: 10.1371/journal.pone.0101414. eCollection 2014. 7: Yu L, Wang N, Zhang Y, Wang Y, Li J, Wu Q, Liu Y. Neuroprotective effect of muscone on glutamate-induced apoptosis in PC12 cells via antioxidant and Ca(2+) antagonism. Neurochem Int. 2014 May;70:10-21. doi: 10.1016/j.neuint.2014.03.003. Epub 2014 Mar 15. doi: 10.1371/journal.pone.0097123. eCollection 2014.
合成参考文献
摘要:Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 1081 摘要:21 CFR 582.50 (4/1/2000) 摘要:S132 | UJIGCAPCICCS | A GC-APCI-IMS-HRMS CCS Library from Izquierdo-Sandoval et al. (2022) | DOI:10.5281/zenodo.15831151 参考文献:10.1007/s10482-005-9049-3 摘要:Waché Y, Husson F, Feron G, Belin JM. Yeast as an efficient biocatalyst for the production of lipid-derived flavours and fragrances. Antonie Van Leeuwenhoek. 2006 Apr;89(3-4):405–16. doi: 10.1007/s10482-005-9049-3.