苯甲醛苯腙置于乙醇,氯,锌体系中,化学反应生成 2,4,6-三氯苯肼 参考文献:Humphries; Humble; Evans,Journal Of The Chemical Society,1925,Vol. 127,P. 1306 标题:Humphries; Humble; Evans,Journal Of The Chemical Society,1925,Vol. 127,P. 1306
专利号:US-6531477-B1 优先权日:1998-10-13 标 题:6-substituted pyrazolo [3,4-d] pyrimidin-4-ones useful as cyclin dependent kinase inhibitors 发明人:MARKWALDER JAY A; SEITZ STEVEN P; SHERK SUSAN R 权利人:DU PONT PHARM CO 摘要:The present invention relates to the synthesis of a novel class of pyrazolo[3,4-d]pyrimidin-4-ones of formula (I), alternatively represented by the tautomer (II):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cyclin dependent kinase 1-8 and their regulatory subunits know as cyclins A-H, K, N, and T.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
专利号:US-6559152-B2 优先权日:1998-10-13 标 题 :6-substituted pyrazolo[3,4-d]pyrimidin-4-ones useful as cyclin dependent kinase inhibitors 发明人:MARKWALDER JAY A; SEITZ STEVEN P; SHERK SUSAN R 权利人:DU PONT PHARM CO 摘要:The present invention relates to the synthesis of a novel class of pyrazolo[3,4-d]pyrimidin-4-ones of formula (I), alternatively represented by the tautomer (II):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cyclin dependent kinase 1-8 and their regulatory subunits know as cyclins A-H, K, N, and T.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
专利号:CN-107663161-A 优先权日:2016-07-27 标 题 :A kind of continuous flow synthesis process of phenylhydrazine salt and substituted phenylhydrazine salt
专利号:RU-2035452-C1 优先权日:1985-12-20 标 题 :Method of n-phenylpyrazole synthesis
专利号:US-3615506-A 优先权日:1970-02-09 标题 :Silver halide emulsions containing 3-cyclicamino-5-pyrazolone color couplers 发明人:ABBOTT JOHN R; COFFEY WILLIAM F 权利人:EASTMAN KODAK CO 摘要:Novel 3-(cyclicamino)-5-pyrazolones and other 3-(substituted amino)-5-pyrazolone couplers valuable for use in color photography are advantageously prepared in good yields from the corresponding 3-alkoxy-5-pyrazolones by a novel single step synthesis in which a mixture of (1) the appropriate 3-alkoxy-5pyrazolone, or a primary amine and (3) an acid catalyst having a pKa smaller than about 10.2 is heated.
参考文献:10.1155/2011/797604 摘要:Jendral JA, Monakhova YB, Lachenmeier DW. Formaldehyde in Alcoholic Beverages: Large Chemical Survey Using Purpald Screening Followed by Chromotropic Acid Spectrophotometry with Multivariate Curve Resolution. International Journal of Analytical Chemistry. 2011;2011():1–11. doi: 10.1155/2011/797604.