CAS: 471-47-6; 2-Amino-2-Oxoacetic Acid

该化合物是一种有机化合物,属于一种属于毒酸类的有机化合物,是毒酸的衍生物,其特点是存在一个氨化物和一个碳酸的功能组,使它在有机合成中成为多种化合物.毒酸一般是一种白色晶状固体,在水和各种有机溶剂中可以溶解.它的化学配方是C2H3N1O3,表明存在两个碳原子,三个氢原子,一个氮原子和三个氧原子.由于碳本酸组的存在,复合酸性较弱,它可以参与各种化学反应,包括恐吓和化.毒酸对生物化学研究感兴趣,并且有可能用于医药和农用化学.此外,它也可以作为其他含氮化合物合成的前体,突出其在有机化学中的重要性.

结构式图片

相似化合物

56-40-6 598-42-5 617-36-7

欧盟法规

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上下游产品

CAS号95-92-1 草酸二乙酯 | CAS号28276-08-6 1,1-二甲基丙基氯化镁 | CAS号139419-63-9 METHYL(2S)-1-(1... | CAS号849585-22-4 2-羟基丙酸 | CAS号617-48-1 DL-苹果酸 | CAS号56-40-6 甘氨酸 | CAS号75-13-8 异氰酸酯 | CAS号144-62-7 草酸 | CAS号471-46-5 草酰二胺 | CAS号19406-51-0 4-氨基-2,6-二硝基甲苯 | CAS号471-46-5 草酰二胺 | CAS号298-12-4 乙醛酸 | CAS号15804-19-0 2,3-二羟基喹喔啉 | CAS号128741-75-3 2-Deoxy-1,3:4,5... | CAS号21141-31-1 草氨酸钾 | CAS号57-13-6 尿素 | CAS号420-05-3 正氰酸 | CAS号49715-78-8 哌嗪-2,3,5,6-四酮

合成工艺路线路线简述

  • 合成目标产物 Oxamic Acid 主要起始原料 1,1-Dimethylpropylmagnesium Chloride And Methyl(2S)-1-(1',2'-Dioxo-2'-Methoxyethyl)-2-Pyrrolidine-Carboxylate
  • (文献来源)合成步骤主要原料 1,1-Dimethylpropylmagnesium Chloride 和 Methyl(2S)-1-(1',2'-Dioxo-2'-Methoxyethyl)-2-Pyrrolidine-Carboxylate
草酸二乙酯置于盐酸,三乙醇胺体系中,用 乙醇,水 作为反应溶剂,化学反应生成 草氨酸
参考文献:Compound Containing An Oxamic Acid Group,A Process For Producing The
标题:Compound Containing An Oxamic Acid Group,A Process For Producing The
摘要:本发明涉及含有羟酰胺酸基团的化合物,其具有高反应性和稳定性,适用于涂料,粘合剂和塑料材料等形式的反应材料或树脂.由于这些化合物中的一部分分子引入了羟酰胺酸基团,而羟酰胺酸基团是一种离子功能基团,因此这些化合物在水中显示出优越的溶解性和分散性.此外,由于羟酰胺酸基团是一种随加热而消失的基团,这些化合物在硬化后不会残留在硬化产品中.因此,从这些化合物得到的硬化产品在耐水性,防腐性和耐久性方面表现出优越性.

海关参考信息

专利信息


专利号:US-8981076-B2
优先权日:2008-11-29
标 题 :Synthesis of N-FMOC protected deoxy nucleosides, ribo nucleosides, modified deoxy and ribo nucleosides, and phosphoramidites, and their use in oligonucleotide synthesis
发明人:SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P
权利人:SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P; CHEMGENES CORP
摘要:This invention relates to synthesis of novel -N-FMOC protected nucleosides, succinates, phosphoramidites, corresponding solid supports that are suitable for oligo deoxy nucleosides and RNA oligonucleotide synthesis. Our discovery using N-FMOC as nucleoside base protecting group, which is highly base labile protecting group is a novel approach to obtain highest purity oligonucleotides. This approach is designed to lead to very high purity and very clean oligonucleotide, after efficient removal of the protecting groups and to produce high purity therapeutic grade DNA oligonucleotides, RNA oligonucleotides, diagnostic DNA, diagnostic RNA for microarray platform. The deprotection of FMOC protecting groups of the natural deoxy and ribonucleosides occurs under very mild deprotection conditions such as mild bases, secondary and tertiary amines for removal of such groups under such conditions would allows synthesis of various DNA and RNA of highest purity for diagnostics and therapeutic application. This approach is further designed to use FMOC protecting group on various base sensitive nucleoside, and for use in oligo peptide synthesis and for support bound oligo nucleotides. DNA oligonucleotides containing 3′-end dA at the 3′-terminal will be produced using the FMOC-dA-supports would lead to much reduced M−1 deletion sequences, and thereby high purity.

专利号:US-2022220061-A1
优先权日:2019-05-09
标 题:Process for the synthesis of the ionic liquid tetraoctylammonium di(2-ethylhexyl)-oxamate (il-5), product obtained and its use in selective metal extraction
发明人:ARRIEGAS ESTEVÃO CORREIA LEAL JOÃO PAULO; DA CUNHA OLIVEIRA FIGUEIRA CARRETAS JOSÉ MANUEL; MARIA CRUZ ADELAIDE; DE JESUS MARIA LEONOR MARIA; RAMOS BATISTA MONTEIRO BERNARDO
权利人:INST SUPERIOR TECNICO
摘要:a) The present invention falls within the area of the synthesis of ionic liquids, namely it concerns a process of synthesis of the ionic liquid tetraoctylammonium di(2-ethylhexyl)-oxamate (IL-5) with a high degree of purity and its use in the extraction and selective separation of metals, namely lanthanides. Thus, it is the object of the present invention, a process for the synthesis of a pure ionic liquid using in its constitution only the elements carbon, hydrogen, oxygen and nitrogen (CHON), assuming itself as a “greenâ€? alternative in the recovery of metals, thus reducing the environmental impact in the way they are recovered, as well as the guarantee of a more efficient extraction of these metals.

专利号:US-8975340-B2
优先权日:2010-12-15
标题 :Synthesis of sequestration resins for water treatment in light water reactors
发明人:YENGOYAN LEON; FRATTINI PAUL L; WELLS DANIEL MORGAN
权利人:YENGOYAN LEON; FRATTINI PAUL L; WELLS DANIEL MORGAN; ELECTRIC POWER RES INST
摘要:An organic synthesis of materials to achieve removal of low molecular weight ionic species, such as transition metal ions including cobalt, iron, nickel, and zinc, from aqueous solutions. The synthesis includes the steps of providing a cation exchange resin, functionalizing the cation exchange resin using a chloride intermediate to form a sulfonyl chloride resin, and reacting a multi-amine based ligand with the sulfonyl chloride resin to form a sequestration resin. The synthesis further includes the steps of cooling the sequestration resin, and washing and drying the sequestration resin.

专利号:US-11059849-B2
优先权日:2014-09-02
标题 :Modified nucleotides for synthesis of nucleic acids, a kit containing such nucleotides and their use for the production of synthetic nucleic acid sequences or genes
发明人:YBERT THOMAS; GARIEL SYLVAIN
权利人:DNA SCRIPT
摘要:A modified nucleotide, intended for the synthesis of long chain nucleic acids by enzymatic processes, comprising a “naturalâ€? nitrogenous base or a natural nitrogenous base analogue, a ribose or deoxyribose carbohydrate, and at least one phosphate group, characterized in that said nucleotide comprises at least one R group, termed the modifier group, carried by said nitrogenous base or analogue and/or by the oxygen in position 3′ of the ribose or deoxyribose molecule, making it possible to block the polymerization of said nucleotide and/or to allow the interaction of said nucleotide with another molecule, such as a protein, during the nucleic acid synthesis, R comprising at least one functional terminal group.

专利号:US-5817751-A
优先权日:1994-06-23
标 题 :Method for synthesis of diketopiperazine and diketomorpholine derivatives
发明人:SZARDENINGS ANNA KATRIN; CAMPBELL DAVID
权利人:AFFYMAX TECH NV
摘要:The present invention relates to the areas of organic and medicinal chemistry. More specifically, the present invention is concerned with combinatorial and solid phase methods for the synthesis of diverse diketopiperazine derivatives, and the use of such methods to create libraries of diverse diketopiperazine derivatives. The present invention has application in the areas of chemical synthesis, the screening for new diketopiperazine derivatives having beneficial medical properties and the use of such screening to provide compositions and methods including diketopiperazine derivatives for treating disease.

专利号:US-6063919-A
优先权日:1998-08-14
标题:Process for the synthesis of exochelins
发明人:GAUDIOSO LARRY A; WEGLARZ MICHAEL A
权利人:KEYSTONE BIOMEDICAL INC
摘要:A process for the synthesis of an Exochelin comprising the steps of generating L-N-[(2-benzyloxy-(benzoyl)] serine or L-N-[2-benzyloxy (benzoyl)] threonine, creating L-N-t-Boc- epsilon -hydroxynorleucine and reacting same to produce L-N-Boc- epsilon -bromonorleucine trimethylsilylethyl ester, providing a dicarboxylic acid and forming an O-benzyl methyl hydroxamate from the dicarboxylic acid, coupling the O-benzyl methyl hydroxamate with the L-N-Boc- epsilon -bromonorleucine trimethylsilylethyl ester to give an L-N2-Boc-N6-methyl,N6-(benzyloxy) lysine 2-trimethylsilylethyl ester which incorporates the dicarboxylic acid as modified above, removing the N-tert-butoxycarbonyl protecting group from the L-N2-Boc-N6-methyl, N6-(benzyloxy) lysine 2-trimethylsilylethyl ester to yield a substituted lysine, and coupling the same with the L-N-[2-benzyloxy (benzoyl) serine or -threonine to yield a 2-trimethyl silylethyl ester of dibenzyl Exochelic acid, transforming the 2-trimethyl silylethyl ester of dibenzyl Exochelic acid to dibenzyl Exochelic acid, preparing benzyl epi-cobactin, forming an ester bond between the dibenzyl Exochelic acid and benzyl epi-cobactin to form an intermediate, and, hydrogenolytically removing three benzyl groups from said intermediate, resulting in the synthesized Exochelin. More particularly, a synthesis for Exochelin 786SM (R) is disclosed wherein the dicarboxylic acid is suberic acid and the serine form is utilized.
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主要参考文献


1: Rodríguez-Páez L, Chena-Taboada MA, Cabrera-Hernández A, Cordero-Martínez J, Wong C. Oxamic acid analogues as LDH-C4-specific competitive inhibitors. J Enzyme Inhib Med Chem. 2011 Aug;26(4):579-86. doi: 10.3109/14756366.2011.566221. Epub 2011 Mar 25. 9(2):292-300. doi: 10.1021/cc060110n. Epub 2007 Feb 23. 36(9-12):1075-83. doi: 10.1080/09593330.2014.974682. Epub 2014 Nov 13. 34(2):600-5. doi: 10.1021/jm00106a020. 63(17):9212-9227. doi: 10.1021/acs.jmedchem.0c00302. Epub 2020 Aug 21.
6: Espinoza LC, Sepúlveda P, García A, Martins de Godoi D, Salazar R. Degradation of oxamic acid using dimensionally stable anodes (DSA) based on a mixture of RuO2 and IrO2 nanoparticles. Chemosphere. 2020 Jul;251:126674. doi: 10.1016/j.chemosphere.2020.126674. Epub 2020 Apr 5. 22(3):487-93. doi: 10.1016/s0731-7085(00)00230-2. 11(10):1409. doi: 10.3390/antibiotics11101409.
9: Koch RL, Goldman P. The anaerobic metabolism of metronidazole forms N-(2-hydroxyethyl)-oxamic acid. J Pharmacol Exp Ther. 1979 Mar;208(3):406-10.

合成参考文献


参考文献:10.1371/journal.pone.0021237
摘要:Penna-Coutinho J, Cortopassi WA, Oliveira AA, França TCC, Krettli AU. Antimalarial Activity of Potential Inhibitors of Plasmodium falciparum Lactate Dehydrogenase Enzyme Selected by Docking Studies. PLoS ONE. 2011 Jul 14;6(7):e21237. doi: 10.1371/journal.pone.0021237.
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