CAS: 46118-95-0; 2-((4-Methylpyrimidin-2-yl)Thio)Acetic Acid

该化合物是一种化学化合物,其独特的结构特征是化学化合物,包括一个以甲基组替代的火水晶环和硫酸.该化合物通常具有在室温下固态等特性,由于碳oxylic酸功能组的存在,极地溶剂中具有中等溶解性.硫醚联系有助于其再活动,使其有可能成为各种化学反应的候选体,包括核生殖器替代.其生物活动可能受到以其在各种生物化学过程中的作用而著称的火晶体环的影响.该化合物还可能表现出与生物目标的具体互动,从而引起对医药化学的兴趣.

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676522-23-9 55749-30-9 876717-59-8

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CAS号79-11-8 氯乙酸 | CAS号35071-17-1 2-疏基-4-甲基嘧啶 | CAS号3926-62-3 氯乙酸钠

合成工艺路线路线简述

    📜氯乙酸,2-Mercapto-6-Methylpyrimidine置于sodium Hydroxide体系中,化学反应生成 2-羧基甲基硫代-4-甲基嘧啶
    参考文献:Synthesis And Biological Study Of Some Novel 4-[5-(4,6-Disubstituted-2-Thiomethylpyrimidyl)-4'-Amino-1,2,4-Triazol-3'-Yl] Thioacetyl-3-Arylsydnones
    标题:Synthesis And Biological Study Of Some Novel 4-[5-(4,6-Disubstituted-2-Thiomethylpyrimidyl)-4'-Amino-1,2,4-Triazol-3'-Yl] Thioacetyl-3-Arylsydnones
    摘要:A Series Of 4-[5-(4,6-Disubstituted-2-Thiomethyl Pyrimidyl)-4'-Amino-1,2-4-Triazol-3'-Yl]Thioacetyl-3-Arylsydnones 7A-I Were Synthesized By The Reaction Of 5-(4,6-Disubstituted-2-Thiomethylpyrimidyl)-4-Amino-3-Mercapto-1,2-4-Triazoles 3 With 3-Aryl-4-Bromoacetyl Sydnones 6 In An Ethanol Medium. The Newly Synthesized Compounds 7A-I Were Screened For Their Antibacterial Activity Against E. Coli And Serratia Marcesens And For Antibacterial Activity Against Aspergillus Niger And Pencillium. Most Of The Tested Compounds Showed Significant Antifungal Activity Particularly Against Pencillium At 10-Mu G/ml Concentration Comparable With That Of The Standard Drug Flukanazole.
    DOI:10.1080/10426500601161049

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    专利信息


    专利号:WO-0053579-A2
    优先权日:1999-03-10
    标 题:Solid phase synthesis of 4-aminoproline derivatives and/or combinatorial libraries thereof

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    合成参考文献


    参考文献:10.1016/j.jbc.2022.102228
    摘要:Scoles DR, Gandelman M, Paul S, Dexheimer T, Dansithong W, Figueroa KP, Pflieger LT, Redlin S, Kales SC, Sun H, Maloney D, Damoiseaux R, Henderson MJ, Simeonov A, Jadhav A, Pulst SM. A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2. Journal of Biological Chemistry. 2022 Aug;298(8):102228. doi: 10.1016/j.jbc.2022.102228.
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