CAS: 4027-57-0; Ethyl 5-Methylpyrazole-3-Carboxylate

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CAS号615-79-2 乙酰丙酮酸乙酯 | CAS号82707-01-5 ethyl 5-cyano-5... | CAS号623-73-4 重氮乙酸乙酯 | CAS号123-38-6 丙醛 | CAS号96-22-0 3-戊酮 | CAS号126580-08-3 2-diazonio-1-et... | CAS号64-17-5 乙醇 | CAS号402-61-9 3-甲基-1H-吡唑-5-甲酸 | CAS号3405-77-4 5-甲基异噁唑-3-甲酸 | CAS号10250-59-6 1,3-二甲基-1H-吡唑-5-甲酸甲酯 | CAS号10250-61-0 1,5-二甲基吡唑-3-甲酸甲酯 | CAS号5744-51-4 1,5-二甲基-1H-吡唑-3-甲酸乙酯 | CAS号5744-40-1 1,3-二甲基-1H-吡唑-5-甲酸乙酯 | CAS号5744-56-9 1,3-二甲基-1H-吡唑-5-甲酸 | CAS号402-61-9 3-甲基-1H-吡唑-5-甲酸 | CAS号40535-14-6 5-甲基-1H-吡唑-3-碳酰肼 | CAS号29004-73-7 5-甲基-1H-吡唑-3-甲醇 | CAS号29400-84-8 4-氯-3-甲基-1H-吡唑-5-羧酸 | CAS号3273-44-7 3-甲基-1H-吡唑-5-甲醛

乙酰丙酮酸乙酯置于一水合肼体系中,化学反应 1.0H,反应生成 3-甲基吡唑-5-甲酸乙酯
参考文献:Synthesis,Characterization And Antibacterial Activity Of Novel Schiff Bases
标题:Synthesis,Characterization And Antibacterial Activity Of Novel Schiff Bases
摘要:本研究描述了从二乙基草酸盐和丙酮作为起始材料合成新型施夫碱(8.1-8.9)的五个步骤.将乙基1-(2-氨基苯基)-5-甲基-1H-吡唑-3-羧酸酯(6)与芳香醛和杂芳香醛(7.1-7.9)在50oc的乙醇中,存在硫酸钠的条件下进行缩合反应,得到相应的亚胺衍生物(8.1-8.9),产率为定量.通过1H NMR,质谱和红外光谱数据确定了这些化合物的结构.这些施夫碱进一步被评估了针对选定的革兰阳性和革兰阴性细菌病原体的抗菌活性.抗菌活性数据显示,嵌有杂芳香环的施夫碱的抗菌活性优于含有芳香环的施夫碱.
DOI:10.14233/ajchem.2016.19768

专利信息

专利号:US-6096898-A
优先权日:1999-10-22
标 题:One pot synthesis of 1,2,4-triazoles
发明人：PODHOREZ DAVID E; HULL JR JOHN W; BRADY CHRISTINE H
权利人:DOW AGROSCIENCES LLC
摘要:One pot synthesis of 1,2,4-triazoles uses thioimidate intermediate and 1,2-dichloroethane solvent.

专利号:EP-1551403-B1
优先权日:2002-10-10
标 题 :5-substituted 2h-pyrazone-3-carboxylic acid derivatives as antilipolytic agents for the treatment of metabolic-related disorders such as dyslipidemia
发明人：SEMPLE GRAEME; AVERBUJ CLAUDIA; SKINNER PHILIP; GHARBAOUI TAWFIK; SHIN YOUNG-JUN
权利人:ARENA PHARM INC
摘要:The present invention relates to certain pyrazole carboxylic acid derivatives of Formula (Ia), and pharmaceutically acceptable salts thereof, as antilipolytic agents and against for the receptor RUP25, wherein: R₂ is H, halogen, C_1-12 alkyl or C_1-12 haloalkyl; and R₃ is C_3-6 cycloalkyl, C_1-12 alkyl, C_1-12 haloalkyl, C_3-6 cycloalkyl-C_1-4-alkylene, aryl-C_1-4-alkylene or heteroaryl-C_1-4-alkylene, wherein said aryl-C_1-4-alkylene and heteroaryl-C_1-4-alkylene can be optionally substituted 1 to 5 substituents selected from the substituents listed in the claims. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for pharmaceutical compositions in combination with other active agents, for example, those agents belonging to the class of alpha-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers, thiazolidinedione and the like.

专利号:WO-9505391-A1
优先权日:1993-08-18
标 题 :Applications of fluorescent n-nucleosides and fluorescent structural analogs of n-nucleosides
发明人：CONRAD MICHAEL J
权利人:CHROMAGEN INC
摘要:Structural analogs of the six non-fluorescent N-nucleosides commonly found in RNA and DNA, which are inherently fluorescent under physiological conditions, are identified and methods for their preparation provided. Such analogs may be incorporated into DNA and/or RNA oligonucleotides via either enzymatic or chemical synthesis to produce fluorescent oligonucleotides having prescribed sequences. Such analogous sequences may be identical to, or the analogous complement of, template or target DNA or RNA sequences to which the fluorescent oligonucleotides can be hybridized. Methods of preparing either RNA or DNA oligonucleotide probes of the invention, intermediates used in such methods, and methods of using the probes of the invention in oligonucleotide amplification, detection, identification, and/or hybridization assays are also provided.

专利号:US-2024383908-A1
优先权日:2021-07-07
标 题 :Synthesis and application of phosphatase degrader

专利号:CN-115594666-B
优先权日:2021-07-07
标 题:Synthesis and application of phosphatase degradation agent

专利号:EP-4368614-A1
优先权日:2021-07-07
标题:Synthesis and application of phosphatase degrader