CAS: 401-81-0; 1-Iodo-3-(Trifluoromethyl)Benzene

上下游产品

CAS号1423-26-3 3-(三氟甲基)苯硼酸 | CAS号98-08-8 三氟甲苯 | CAS号401-78-5 间溴三氟甲苯 | CAS号591-50-4 碘苯 | CAS号81290-20-2 (三氟甲基)三甲基硅烷 | CAS号98-16-8 间三氟甲苯胺 | CAS号139-02-6 苯酚钠 | CAS号81447-72-5 m-(trifluoromet... | CAS号55642-42-7 trifluoro(trifl... | CAS号109272-29-9 1-(4-溴苯氧基)-3-(三氟甲基)苯 | CAS号106336-12-3 N,N-diphenyl-3-... | CAS号603-34-9 三苯胺 | CAS号58313-23-8 3-碘苯甲酸乙酯 | CAS号363-95-1 4,4'-二硝基-3,3'-双... | CAS号454-90-0 间三氟甲基苯甲醚 | CAS号325142-82-3 3-(三氟甲基)苯硼酸频哪醇酯 | CAS号454-92-2 3-三氟甲基苯甲酸 | CAS号454-89-7 间三氟甲基苯甲醛 | CAS号349-76-8 间三氟甲基苯乙酮

三氟甲苯置于dipotassium Peroxodisulfate,硫酸,碘体系中,用 二氯甲烷,三氟乙酸 作为反应溶剂,化学反应 2.0H,以69%的收率获得产物3-碘三氟甲苯
参考文献:使用分子碘从芳香底物直接合成碘芳烃
标题:使用分子碘从芳香底物直接合成碘芳烃
摘要:介绍了芳烃底物氧化碘化的简单实验室程序.一种方法包括使用分子碘,浓硫酸和过二硫酸钾进行碘化,另一种方法使用含有分子碘,过二硫酸钾和三氟乙酸的试剂系统.这些程序对苯和较少失活的芳族底物特别有效,例如卤代苯,三氟甲基苯和苯甲酸.
DOI:10.1055/s-2008-1032165

专利信息

专利号:US-10844081-B2
优先权日:2015-08-07
标题 :Protected organoboronic acids with tunable reactivity, and methods of use thereof
发明人：BURKE MARTIN D; SCHMIDT MICHAEL; MOREHOUSE GREG; PIPAL ROBERT W
权利人:UNIV ILLINOIS
摘要:Disclosed are a range of protected organoboronic acid reagents useful in the modular assembly of complex organic compounds. The reactivities of the protected organoboronic acid reagents may be varied predictably by changes to the number and identities of their substituents. Also disclosed are methods of using the protected organoboronic acid reagents in the synthesis of organic compounds.

专利号:US-5922906-A
优先权日:1997-09-05
标 题:Side chains synthesis for an anthiarrhythmic compound
发明人：LYNCH JOSEPH E; SHI YAO-JUN; WELLS KENNETH M
权利人:MERCK & CO INC
摘要:The present invention is directed to an improved process for preparing the phenylacetic acid side chain of the compound of the formula This compound exhibits utility as a Class III antiarrhythmic agent.

专利号:WO-0009116-A1
优先权日:1998-08-14
标 题:Grp receptor ligands
发明人：XIANG JIA-NING; KARPINSKI JOSEPH M; CHRISTENSEN SIEGFRIED B IV
权利人:SMITHKLINE BEECHAM CORP; XIANG JIA NING; KARPINSKI JOSEPH M; CHRISTENSEN SIEGFRIED B IV
摘要:Novel GRP receptor antagonists are provided. Methods of using the present compounds to antagonize GRP receptors are also provided. The present invention further involves the synthesis of the present compounds.

专利号:US-12227528-B2
优先权日:2017-11-09
标 题:Glucose-sensitive albumin-binding derivatives
发明人：KRUSE THOMAS; KOFOD-HANSEN MIKAEL; MUENZEL MARTIN WERNER BORCHSENIUS; THOEGERSEN HENNING; SAUERBERG PER; EWALD JAKOB; BEHRENS CARSTEN; HOEG-JENSEN THOMAS; BALSANEK VOJTECH; DROBNAKOVA ZUZANA; DROZ LADISLAV; HAVRANEK MIROSLAV; KOTEK VLADISLAV; STENGL MILAN; SNAJDR IVAN; DRUSANOVA HANA
权利人:NOVO NORDISK AS
摘要:This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates.

专利号:WO-2007002173-A1
优先权日:2005-06-22
标 题:Hiv-1 protease inhibitors, and methods of making and using them
发明人：RANA TARIQ M; ALI AKBAR; CAO HONG; SAI KIRAN KUMAR REDDY GA; ANJUM SAIMA GHAFOOR
权利人:UNIV MASSACHUSETTS; RANA TARIQ M; ALI AKBAR; CAO HONG; SAI KIRAN KUMAR REDDY GA; ANJUM SAIMA GHAFOOR
摘要:One aspect of the invention relates to the design, synthesis and biological activity of novel HIV-1 protease inhibitors incorporating N-phenyloxazolidine-5-carboxamides into the (hydroxyethylamino)sulfonamide scaffold as P2 ligands. For example, the present invention relates to inhibitors with variations at the P2 phenyloxazolidine and the P2' phenylsulfonamide moieties. Remarkably, compounds with an (S)-enantiomer of substituted phenyloxazolidines at P2 show highly potent inhibitory activities against wild-type HIV-1 protease. In certain embodiments, the inhibitors of the invention have Ki values in low picomolar (pM) range. In certain embodiments, the inhibitors of the invention were shown to be active against a variety of multi-drug resistant (MDR) HIV-1 proteases, each representing different paradigm of drug resistance.

专利号:CN-1829673-A
优先权日:2001-12-14
标 题 :Synthesis of alpha, beta-trifluorostyrene by in situ formation of trifluorovinyl metal halide