CAS: 331834-13-0; Benzofuran-5-Ylboronic Acid

相似化合物

519054-55-8 1432610-21-3 98437-24-2

上下游产品

5-bromobenzofuran Triisopropyl borate water Trimethyl borate5-[4-(trans-4-pentylcyclohexyl)phenyl]-1-benzofuran 24H23N3O4S2C24H23N3O4S2 24H23N3O4S2C24H23N3O4S2 23H22N4O4S2C23H22N4O4S2

📜5-溴苯并呋喃置于四羟基二硼,1,3-Bis[(Diphenylphosphino)Propane]Dichloronickel(II),N,N-二异丙基乙胺,三苯基膦体系中,用 乙醇 作为反应溶剂,化学反应 4.0H,反应生成 苯并呋喃-5-硼酸
参考文献:镍催化四羟基二硼 [b2(Oh)4] 卤化物和拟卤化物的硼化反应
标题:镍催化四羟基二硼 [b2(Oh)4] 卤化物和拟卤化物的硼化反应
摘要:芳基硼酸作为试剂和目标结构在各种有用的应用中变得越来越重要.最近,报道了使用原子经济的四羟基二硼(bba)试剂在钯催化下合成芳基硼酸.钯的高成本,加上钯和铜催化工艺的一些限制,促使我们开发一种替代方法.因此,已经制定了使用四羟基二硼(bba)对芳基和杂芳基卤化物和拟卤化物进行镍催化的硼基化反应.该反应被证明具有广泛的官能团耐受性并适用于许多杂环体系.据我们所知,这里提供的例子代表了在室温下进行的唯一有效的镍催化宫浦硼化反应.
DOI:10.1021/jo401104Y

专利信息

专利号:US-2009137566-A1
优先权日:2005-05-26
标 题 :Substituted Piperdines as Renin Inhibitors
发明人：EHARA TAKERU; HITOMI YUKO; KONISHI KAZUHIDE; MASUYA KELICHI
权利人:EHARA TAKERU; HITOMI YUKO; KONISHI KAZUHIDE; MASUYA KELICHI
摘要:The invention relates to substituted 3,4- or higher substituted piperididine compounds, the use thereof for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; pharmaceutical formulations or products comprising said compounds, and/or a method of treatment comprising administering said compounds, a method for the manufacture of said compounds, as well as novel intermediates, starting materials and/or partial steps for their synthesis. The compounds preferably have the formula I, n n n n n n n n n n wherein the moieties R1, R2, R11 and W are as defined in the specification.