CAS: 29741-09-1; (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-((5-Hydroxy-2-(4-Hydroxyphenyl)-4-Oxo-4H-Chromen-7-yl)Oxy)Tetrahydro-2H-Pyran-2-Carboxylic Acid

上下游产品

CAS号520-36-5 芹菜素; 芹黄素; 5,7,4... | CAS号2616-64-0 UDP葡萄糖醛酸 | CAS号6556-12-3 D-葡萄糖醛酸 | CAS号520-36-5 芹菜素; 芹黄素; 5,7,4...

📜德国春黄菊油置于盐酸,三(3,6-二氧杂庚基)胺,水,Potassium Carbonate,三乙胺,Sodium Hydroxide体系中,用 四氢呋喃,二氯甲烷,水,异丙醇,丙酮 用作溶剂,化学反应 38.17H,反应生成芹菜素-7-葡萄糖醛酸
参考文献:一种5,4'-二羟基黄酮-7-O-D-葡萄糖醛酸的 制备方法
标题:一种5,4'-二羟基黄酮-7-O-D-葡萄糖醛酸的 制备方法
摘要:本发明涉及药物合成技术领域,尤其涉及一种5,4'‑二羟基黄酮‑7‑o‑d‑葡萄糖醛酸的制备方法.该方法包括以下步骤:取式ii所示结构化合物,碱性条件下经酰化,制得式iii所示结构化合物;取式iii所示结构化合物与α‑溴代三乙酰氧基葡醛酸甲酯,经糖苷化反应,制得式iv所示结构化合物;取式iv所示结构化合物,酸性条件下水解制得式v所示结构化合物;取式v所示结构化合物,碱性条件下水解,即得.本发明提供的方法起始原料廉价易得,反应步骤少,工艺简单易操作,适合大规模工业化生产,经检测,所得产物纯度可达98%以上,总收率高达56%.

专利信息

专利号:WO-2024219698-A1
优先权日:2023-04-19
标 题 :Composition for preventing, ameliorating, or treating arthritis, containing potentilla chinensis extract or apigenin-7-o-glucuronide as active ingredient
发明人：JUNG BYUNG CHAN; LEE SUN HEE; LEE KYUNG-TAE; LEE SANG OK; SHIN DONG MIN
权利人:BELABELBIO INC
摘要:The present invention discloses a composition for preventing, ameliorating, or treating arthritis, the composition containing a Potentilla chinensis extract or apigenin-7-O-glucuronide as an active ingredient. The present invention inhibits the expression of MMP-1 and MMP-9, increases the synthesis of procollagen type 2, and not only alleviates inflammation but also inhibits inflammatory pain, and thus has the effect of preventing, ameliorating, or treating arthritis.

专利号:CN-116515876-A
优先权日:2022-01-20
标题:Regulation method and application of heterologous synthesis of flavonoids

专利号:US-9238821-B2
优先权日:2009-04-14
标题 :Metabolic engineering for plant disease resistance
发明人：LI WENSHENG; UPPALAPATI SRINIVASA RAO; MYSORE KIRANKUMAR S; DIXON RICHARD A; SUMNER LLOYD W
权利人:LI WENSHENG; UPPALAPATI SRINIVASA RAO; MYSORE KIRANKUMAR S; DIXON RICHARD A; SUMNER LLOYD W; SAMUEL ROBERTS NOBLE FOUND INC
摘要:The invention provides methods and compositions for making a dicotyledonous plant that is susceptible to Phymatotrichopsis Root Rot (PRR) more resistant to PRR, by metabolic engineering of the plant's flavonoid and isoflavonoid biosynthetic pathways. Thus, methods for increasing the synthesis and accumulation of medicarpin and/or 7,4′-dihydroxyflavone in plants such as alfalfa are provided.