CAS: 2613-89-0; Phenylmalonic Acid

上下游产品

CAS号83-13-6 苯基丙二酸二乙酯 | CAS号98-87-3 二氯苄 | CAS号124-38-9 二氧化碳 | CAS号108-88-3 甲苯 | CAS号103-82-2 苯乙酸 | CAS号7147-33-3 Alpha-乙氧草酰基苯乙酸乙酯 | CAS号140-29-4 苯乙腈 | CAS号101-97-3 苯乙酸乙酯 | CAS号114-70-5 苯乙酸钠 | CAS号2785-29-7 potassium,metha... | CAS号497-25-6 2-恶唑烷酮 | CAS号80372-12-9 bis(trimethylsi... | CAS号492-38-6 2-苯基丙烯酸 | CAS号103-82-2 苯乙酸 | CAS号100-52-7 苯甲醛 | CAS号4370-95-0 3-氨基-2-苯基丙酸 | CAS号101-41-7 苯乙酸甲酯 | CAS号83-13-6 苯基丙二酸二乙酯 | CAS号2001-28-7 4'-甲基-2-苯基乙酰苯 | CAS号7391-66-4 1,3-二甲基-5-苯基巴比妥酸

Alpha-乙氧草酰基苯乙酸乙酯置于水,Potassium Hydroxide体系中,化学反应 12.0H,反应生成苯丙二酸
参考文献:Malki,Fatiha; Touati,Abdelkader; Rahal,Said,Asian Journal Of Chemistry,2011,Vol. 23,# 3,P. 961-967
标题:Malki,Fatiha; Touati,Abdelkader; Rahal,Said,Asian Journal Of Chemistry,2011,Vol. 23,# 3,P. 961-967

专利信息

专利号:US-10913747-B2
优先权日:2017-07-04
标题 :Efficient process for the preparation of sitagliptin through a very effective preparation of the intermediate 2,4,5-trifluorophenylacetic acid
发明人：DE LUCCHI OTTORINO; PADOVAN PIERLUIGI; BRASOLA ELENA
权利人:FIS FABBRICA ITALIANA SINTETICI SPA; F I S —FABBRICA ITALIANA SINTETICI S P A
摘要:Object of the present invention is an efficient process for the preparation of the active pharmaceutical ingredient Sitagliptine and the 2,4,5-trifluorophenylacetic acid (TFAA) and salt thereof, which is a key intermediate for the synthesis of Sitagliptine.

专利号:US-4111933-A
优先权日:1976-04-30
标题:Protection of functional groups during reaction and their subsequent restoration
发明人：ECKERT HEINER; UGI IVAR; KABBE HANS-JOACHIM
权利人:BAYER AG
摘要:In the process for preparing an organic compound of the formula n n A' -- X n n in which n X is an amino group, a hydroxyl group or a carboxyl group, and n A' is the remainder of the molecule, from an organic compound of the formula n n A -- X n n in which n A is the remainder of the molecule which can undergo reaction to form A', by converting A -- X into a compound of the formula n n A -- Z -- COOR n n in which n Z is --NH--, --O-- or a direct C--C bond, and n R is a radical of the formula ##STR1## IN WHICH Y is a direct C--C single bond, the --CHâ•?CH-- group or an arylene group, n R 1 to R 4 each independently is hydrogen, halogen or an alkyl, aryl, aralkyl, alkoxycarbonyl, alkylaminocarbonyl, arylaminocarbonyl or cycloalkylaminocarbonyl radical, or n R 1 + r 2 and R 3 + R 4 each independently completes a 5- or 6-membered carbocyclic ring, or n R 1 and R 3 conjointly with the grouping --C--Y--C-- forms a carbocyclic ring with 5 or 6 carbon atoms, and Hal is halogen, n Thereby to protect X, then converting A -- Z -- COOR into a compound of the formula n n A' -- Z -- COOR n n and then treating the compound A' -- Z -- COOR to restore the group X, the improvement which comprises effecting the treatment of the compound A' -- Z -- COOR with an alkali metal compound of a complex of monovalent cobalt. The process is applicable particularly to aminocarboxylic acids including intermediates from various stages of the synthesis of penicillins and cephalosporis.

专利号:US-3759898-A
优先权日:1971-09-14
标 题 :Synthesis of alpha-(carbo(5-indanyloxy)) benzylpenicillin
发明人：NAKANISHI S
权利人:PFIZER
摘要:THE PREPARATION OF A-(CARBO(5-INDANYLOXY))BENZYLPENICILLIN VIA THE ESTERIFICATION OF A-CARBOXYPENICILLIN WITH 5-INDANOL IN THE PRESENCE OF N, N''-DICYCLOHEXYLCARBODIIMIDE IN A REACTION-INERT SOLVENT AT A PH OF 2-8.

专利号:US-2004068141-A1
优先权日:2002-10-08
标 题 :Process for the synthesis of trifluorophenylacetic acids
发明人：ARMSTRONG JOSEPH D; DREHER SPENCER D; IKEMOTO NORIHIRO
摘要:The present invention addresses a process for the preparation of 2,4,5-trifluorophenylacetic acid using a Cu(I) salt as a catalyst.

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人：CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

专利号:BR-112020010832-B1
优先权日:2017-12-05
标题 :CHEMICAL PROCESS FOR THE SYNTHESIS OF PYRAZOLIDINEDIONE HERBICIDAL COMPOUNDS