CAS: 25574-11-2; 3-(4-Bromophenyl)Propan-1-Ol

上下游产品

3-(4-bromophenyl)acrylic acid methyl 3-(4-bromopehynl)propanoate 3-Phenyl-1-propanol tert-butyl 3-(4-bromophenyl)propanoate trans-1-(3-bromopropyl)-4-bromobenzene [3-(4-bromophenyl)propoxy](tert-butyl)dimethylsilane 1-bromo-4-(3-tert-butoxypropyl)benzene 1-bromo-4-(3-{2-tetrahydropyranyl}oxypropyl)benzene

3-(4-溴苯基)丙-2-烯-1-醇置于5%-Palladium/activated Carbon,氢气体系中,化学反应生成4-溴苯丙醇
参考文献:抗肿瘤剂.565. 考布他汀 D-2 磷酸盐和二氢考布他汀 D-2(1) 的合成
标题:抗肿瘤剂.565. 考布他汀 D-2 磷酸盐和二氢考布他汀 D-2(1) 的合成
摘要:设计了一种改良的考布他汀 D-2 ( 5 )合成路线,以进一步评估其生物活性,将其转化为磷酸盐前药 ( 25-28 ),并作为获得二氢考布他汀 D-2 ( 42 )的途径. 从饱和的 3-苯基丙酸酯中间体开始,通过 Ullmann 联芳醚反应 ( 39-41 ),完成了二氢考布他汀 D-2 的平行第一次全合成.与考布他汀 D-2 表现出的癌细胞生长抑制活性相反,相对较小的结构修饰 ( 41,42 ) 导致这些特性的消除.
Doi:10.1021/np800635H

专利信息

专利号:US-2015045564-A1
优先权日:2012-01-03
标 题 :Cu-MEDIATED ANNULATION FOR THE EFFECTIVE SYNTHESIS OF 3-SUBSTITUTED PHTHALIDES
发明人：REDDY SANTHOSH REKULA; PRAGATI KISHORE PRASAD; NAGA KIRAN; SUDALAI ARUMUGAM
权利人:COUNCIL SCIENT IND RES
摘要:The present invention disclosed herein is a novel commercially feasible, one pot synthesis of library of 3-substituted phthalides of formula I via CuCN mediated oxidative cyclization in high yield. Formula I

专利号:CN-114671744-A
优先权日:2020-12-24
标 题 :A Green Method for Synthesis of Compounds Containing Biaryl Structures by Suzuki Coupling Reaction

专利号:US-5145865-A
优先权日:1989-04-19
标 题 :Phenylcarboxylic acid derivatives having hetero ring
发明人：FUJII SETSURO; FUJII ADMINISTRATOR BY SHINICH; TAKADA ADMINISTRATOR BY KAORUK; KAWAMURA HIROYUKI; WATANABE SHINICHI
权利人:OTSUKA PHARMA CO LTD
摘要:Phenylcarboxylic acid derivatives having a hetero ring in the substituent of the formula: ##STR1## wherein R 1 is halogen, alkyl, cycloalkyl, hydroxy, alkoxy, phenoxy which has a substituent selected from halogen and alkyl, carboxyl, alkylsulfonyloxy, phenylsulfonyloxy optionally substituted by halogen, alkylsulfonyloxyalkoxy, amino, alkanoylamino, benzoylamino, alkenyloxy, phenylalkoxyalkoxy, hydroxyalkoxy, phenylalkoxy having optionally 1 to 3 substituents selected from halogen, alkyl and alkoxy, halogenoalkyl, cycloalkyloxy optionally substituted by hydroxy, alkoxy substituted by cycloalkyl having optionally hydroxy substituent, imidazolylalkyl or imidazolylalkoxy; k is 0 or 1 to 3; or (R 1 ) k is alkylenedioxy; A is alkylene or alkylenoxy; l is 0 or 1; B is methylene or carbonyl; m is 0 or 1; D is alkylene; E is alkylene or alkenylene; n is 0 or 1; and R 2 is hydrogen or alkyl, or a salt thereof, which have fatty acid synthesis-inhibitory activity, cholesterol synthesis-inhibitory activity and are useful as antilipidemic agent, prophylactic and treating agent of arteriosclerosis, prophylactic and treating agent of obesity, antidiabetics.

专利号:CN-111378456-B
优先权日:2018-12-29
标题:A kind of negative liquid crystal compound containing alkenyl terminal and its synthesis method

专利号:CN-112811994-B
优先权日:2019-11-18
标题:A kind of difluoroether compound whose terminal group is 3-pentenyl and its synthesis method

专利号:CN-112811994-A
优先权日:2019-11-18
标题:A class of difluoroether compounds whose terminal group is 3-pentenyl and its synthesis method