CAS: 24424-99-5; Di-Tert-Butyl Dicarbonate

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3-Benzyl-9-Tert-Butyloxycarbonyl-3,9-Diazabicyclo[3.3.1]Nonane置于palladium 10% On Activated Carbon,氢气体系中,用 乙醇 用作溶剂,20.0 °C,303.99 Kpa 条件下,以99%的收率获得二碳酸二叔丁酯
参考文献:Hiv-1 抑制剂 Bms-378806 的合成二氮杂双环类似物的建模和光谱研究及其抗病毒活性的评价
标题:Hiv-1 抑制剂 Bms-378806 的合成二氮杂双环类似物的建模和光谱研究及其抗病毒活性的评价
摘要:Bms-378806 的三个二氮杂双环类似物,其中存在于其哌嗪环上的轴向甲基被碳桥取代,通过病毒中和试验在一组六个假病毒上合成和测试.二氮杂双环辛烷和壬烷衍生物保持了显着的降低传染性的能力,而二氮杂双环庚烷衍生物的效果要差得多.建模研究允许将抗病毒活性与化合物的构象偏好联系起来.此外,与 Bms-378806 类似,理论计算预测存在不同的构象族,对应于化合物的两个平面酰氨基功能的可能排列.高场 1 H NMR 光谱证实了这些结果,因为它们显示了两个不同的信号系列.
Doi:10.1002/ejoc.201001073

专利信息

专利号:US-6683189-B1
优先权日:1996-02-26
标 题 :Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
发明人：DERVAN PETER B; BAIRD ELDON
权利人:CALIFORNIA INST OF TECHN
摘要:The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from aromatic carboxylic acids and aromatic amines with high stepwise coupling yields (>99%), providing milligram quantities of highly pure polyamides. The present invention also describes the synthesis of analogs of the natural products Netropsin and Distamycin A, two antiviral antibiotics. The present invention also describes a novel method for the solid phase synthesis of imidazole and pyrrole carboxamide polyamide-oligonucleotide conjugates. This methodology will greatly increase both the complexity and quantity of minor-groove binding polyamides and minor-groove binding polyamide-oligonucleotide conjugates which can be synthesized and tested.

专利号:US-2007287843-A1
优先权日:2004-04-07
标题 :Methods and Intermediates for the Synthesis of Delta-9 Tetrahydrocannabinol
发明人：CABAJ JOHN E; PARIZA RICHARD J; LUKESH JULIE M
权利人:CABAJ JOHN E; PARIZA RICHARD J; LUKESH JULIE M
摘要:Processes are disclosed for the synthesis of Delta-9 tetrahydrocannabinol which result in an improved Y-THC/Y-THC ratio, and intermediates are disclosed that may be used in the synthesis of Delta-9 tetrahydrocannabinol such that improved Y-THCIY-THC ratios are achieved. The intermediates may be cyclic compounds prepared from 2-Carene. There is also provided a scaleable process for the preparation of (+)-p-menth-2-ene-1,8-diol, another intermediate used in the synthesis of delta-9-tetrahydrocannibinol.

专利号:US-7230101-B1
优先权日:2002-08-28
标 题:Synthesis of methotrexate-containing heterodimeric molecules
发明人：MURTHI KRISHNA K; SMITH CHASE C
权利人:GPC BIOTECH INC
摘要:The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target. In certain embodiments, the invention contemplates the synthesis of the following methotrexate-containing heterodimeric probe:

专利号:US-2025051339-A1
优先权日:2021-12-15
标题:Methods for the synthesis of complement factor d inhibitors
发明人：HASHIMOTO AKIHIRO
权利人:ALEXION PHARMA INC
摘要:The present disclosure provides methods for the synthesis of complement factor D inhibitors and intermediates thereof. The methods involve subjecting an intermediate in the synthesis of a complement factor D inhibitor to a t-butyl ester deprotection reaction using a weak base.

专利号:US-6207858-B1
优先权日:1999-03-03
标 题 :Regioselective synthesis of DTPA derivatives
发明人：CHINN PAUL; GYORKOS ALBERT; LABARRE MICHAEL J; RUHL STEVE; RYSKAMP THOMAS
权利人:IDEC PHARMA CORP
摘要:The present invention provides a process for high yield regioselective synthesis of DTPA derivatives that eliminates the need for ion exchange chromotographic separation of intermediates. Moreover, as this process yields a single regioisomer of the chelate, it provides for the regiospecific synthesis of desired chelates useful as radiolabeling agents.

专利号:US-8293930-B1
优先权日:2004-06-25
标题 :One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
发明人：NAIDU RAGINA
权利人:NAIDU RAGINA; CHATHAM BIOTEC LTD
摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction of protecting the C-7 and C-10 positions and attaching a side chain at the C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and taxane intermediates.