CAS: 21717-95-3; 2-Amino-3-Fluoropyridine

相似化合物

54231-35-5 732306-31-9 21717-96-4

上下游产品

CAS号628322-77-0 benzhydrylidene... | CAS号17282-04-1 2-氯-3-氟吡啶 | CAS号1269440-67-6 3-氟-4-碘吡啶-2-胺 | CAS号1321612-85-4 3-氟-5-碘吡啶-2-胺 | CAS号139022-26-7 8-氟咪唑并[1,2-a]吡啶 | CAS号1211590-31-6 3-氟-5-甲基吡啶-2-胺

N-(3'-Fluoropyridin-2'-Ylamino)Pyridinium Bromide Hydrobromide置于platinum On Activated Charcoal Ammonium Formate体系中,用 甲醇 用作溶剂,化学反应 168.0H,以94%的收率获得2-氨基-3-氟吡啶
参考文献:N-Azinylpyridinium N-Aminides: Intermediates For The Regioselective Synthesis Of 3-Fluoro-2-Aminopyridine Derivatives
标题:N-Azinylpyridinium N-Aminides: Intermediates For The Regioselective Synthesis Of 3-Fluoro-2-Aminopyridine Derivatives
摘要:
Doi:10.1021/jo9813540

专利信息

专利号:EP-3929197-B1
优先权日:2015-08-12
标 题:Intermediates for the synthesis of microbiocidal heterobicyclic derivatives

专利号:US-10738028-B2
优先权日:2016-05-11
标题:Spiro three-membered ring, spiro five-membered ring peptide deformylase inhibitor and use thereof in antibacteria and anti-tumor
发明人：HU WENHAO; LV FENGPING; TANG YANG; LI ZIYAN; CHEN CHEN; WEI JIANHAI; DONG SUZHEN; QIAN YU
权利人:RUDONG RUIEN PHARMACEUTICAL TECH CO LTD
摘要:Disclosed are the anti-bacterial activity and the anti-tumor activity of a class of new spiro three-membered ring and spiro five-membered ring peptide deformylase inhibitor. The spiro three-membered ring and spiro five-membered ring peptide deformylase inhibitor of the present invention, as a class of new anti-bacterial agent, are effective against many antibiotic-resistant Gram-positive strains by inhibiting the activity of the peptide deformylase required in the synthesis of bacterial proteins, and do not affect the synthetic process of the main proteins of the human body, thus selectively killing bacteria. The spiro three-membered ring and spiro five-membered ring peptide deformylase inhibitor of the present invention, as a class of new anti-bacterial agent, can affect the energy balance of the cancer cells through inhibiting the peptide deformylase of the mitochondria in the cells, so that the mitochondrial membrane is depolarized, ATP is exhausted and cell apoptosis is promoted, and has good inhibitory activities on many cancer cell strains such as colorectal cancer, leukemia, lung cancer, gastric cancer, cervical cancer, breast cancer, prostatic cancer, liver cancer and osteosarcoma at relatively lower concentrations. The structure of exemplary invention spiro three-membered ring and spiro five-membered ring peptide deformylase inhibitors are represented by one or more of:

专利号:EP-2336315-A2
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-11731956-B2
优先权日:2018-10-22
标 题:Substituted 1,2,4-triazoles as intermediates in the synthesis of TYK2 inhibitors

专利号:ES-2987575-T3
优先权日:2015-08-12
标 题:Intermediates for the synthesis of microbicidal heterobicyclic derivatives

专利号:EP-3929197-A1
优先权日:2015-08-12
标题:Intermediates for the synthesis of microbiocidal heterobicyclic derivatives