CAS: 20850-49-1; 2-(3,4-Dimethoxyphenyl)-3-Methylbutanenitrile

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CAS号93-17-4 3,4-二甲氧基苯乙腈 | CAS号75-26-3 2-溴丙烷 | CAS号14046-55-0 1-Propanone,1-(... | CAS号105-39-5 氯乙酸乙酯 | CAS号109-70-6 1-溴-3-氯丙烷 | CAS号7677-24-9 三甲基氰硅烷 | CAS号67031-41-8 BENZYL ALCOHOL,... | CAS号102201-29-6 α-isopropyl-ver... | CAS号34245-14-2 rac D 617(N-甲基-... | CAS号36622-28-3 S-维拉帕米 | CAS号27339-25-9 3-(3,4-dimethox... | CAS号27487-83-8 5-氯-2-(3,4-二甲氧基... | CAS号102201-30-9 2-(3,4-dimethox... | CAS号27487-66-7 5-氨基-2-(3,4-二甲氧...

3,4-二甲氧基苯乙酸置于氯化亚砜,四磷十氧化物,四丁基碘化铵,Sodium Hydroxide体系中,用 水,二甲基亚砜,甲苯 用作溶剂,化学反应 4.5H,反应生成3-甲基-2-(3,4-二甲氧基苯基)丁腈
参考文献:一种α-异丙基-3,4-二甲氧基苯乙腈的合成方法
标题:一种α-异丙基-3,4-二甲氧基苯乙腈的合成方法
摘要:本发明属于有机合成技术领域,具体公开了一种α‑异丙基‑3,4‑二甲氧基苯乙腈的合成方法.以3,4‑二甲氧基苯乙酸为原料,经酰化反应生成2‑(3,4‑二甲氧基苯基)乙酰胺,再经脱水得到3,4‑二甲氧基苯乙腈后,经烷烃化反应生成α‑异丙基‑3,4‑二甲氧基苯乙腈.本发明起始原料廉价易得,避免使用剧毒危化试剂,反应条件温和,后处理简单,合成路线短且收率较高.

专利信息

专利号:US-5097058-A
优先权日:1987-04-08
标题:Process for the synthesis of the α-(-methyl-ethyl)-3,4-dimethoxybenzene-acetonitrile
发明人：CANNATA VINCENZO; TAMERLANI GIANCARLO; ZAGNONI GRAZIANO
权利人:ALFA WASSERMANN SPA
摘要:New process for the synthesis of the α-(1-m.ethylethyl)-3,4-dimethoxyacetonitrile of formula (I): ##STR1## which is known as an intermediate in the synthesis of the drug internationally known as verapamil. The process starts from the isobutyryl-3,4-dimethoxybenzene of formula (II): ##STR2## which, by means of the Darzens condensation, gives an epoxyester which, by alkaline hydrolysis and subsequent decarboxylation, gives the α-(1-methylethyl)-3,4-dimethoxybenzeneacetaldehyde. This product is reacted with hydroxylamine to obtain the corresponding oxime that, by dehydration, gives the nitrile of formula I.

专利号:US-2010184989-A1
优先权日:2007-03-12
标 题 :De Novo Synthesis of Conjugates
发明人：RIGGS-SAUTHIER JENNIFER; DENG BO-LIANG; REN ZHONGXU; ZHANG WEN; GU XUYUAN; DUARTE FRANCO J
权利人:NEKTAR THERAPEUTICS
摘要:The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path.

专利号:US-7279466-B2
优先权日:1998-01-09
标题:Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof

专利号:US-2007073077-A1
优先权日:1998-01-09
标题:Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof

专利号:AU-2008226820-A1
优先权日:2007-03-12
标题 :De novo synthesis of conjugates

专利号:CA-2679473-A1
优先权日:2007-03-12
标题:De novo synthesis of conjugates