CAS: 20733-10-2; 4-Hydroxypyridazine

相似化合物

20733-11-3 1415928-75-4 1245643-70-2

上下游产品

3,6-dichloropyridazin-4-ol

📜3,6-二氯哒嗪-4-醇置于palladium On Activated Charcoal,乙醇体系中,化学反应生成4-羟基哒嗪
参考文献:杂环研究中的化学研究.16. Mitteilung.哒嗪.3,4,6-三氯哒嗪取代
标题:杂环研究中的化学研究.16. Mitteilung.哒嗪.3,4,6-三氯哒嗪取代
摘要:3,4,6-三氯哒嗪被转化为许多新化合物,其结构由其化学和光谱性质确定.
Doi:10.1002/hlca.19560390634

专利信息

专利号:US-6025492-A
优先权日:1996-08-30
标 题 :Synthesis of a hydrazone β-keto ester by the reaction with a diazo ester
发明人：SHAH AJIT S; CLARK JERRY D; MA YINONG; PETERSON JAMES C; PATELIS LEFTERIS
权利人:MONSANTO CO
摘要:The present invention relates to the synthesis of a hydrazone β-keto ester by the reaction of an alkyl diazoester with a hydrazone aldehyde in the presence of a Lewis acid In a preferred embodiment, the hydrazone β-keto ester is then converted into a pyridazinone compound by the reaction with an alkyl acid chloride in the presence of a base, followed by acidification. A process for the production of a hydrazone aldehyde, which comprises contacting a hydrazine and glyoxal, is also described.

专利号:EP-0923540-B1
优先权日:1996-08-30
标题 :Synthesis of a hydrazone beta-keto ester by the reaction with a diazo ester
发明人：SHAH AJIT S; CLARK JERRY D; MA YINONG; PETERSON JAMES C; PATELIS LEFTERIS
权利人:MONSANTO TECHNOLOGY LLC
摘要:The present invention relates to the synthesis of a hydrazone β-keto ester by the reaction of an alkyl diazo ester with a hydrazone aldehyde in the presence of a Lewis acid. In a preferred embodiment, the hydrazone β-keto ester is then converted into a pyridazinone compound by the reaction with an alkyl acid chloride in the presence of a base, followed by acidification. The present invention also relates to a continuous process for the production of a hydrazone aldehyde comprising contacting a hydrazine and glyoxal, wherein the hydrazine and the glyoxal are added simultaneously to a reactor at a controlled rate.

专利号:WO-2023086799-A1
优先权日:2021-11-09
标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:WO-9808807-A1
优先权日:1996-08-30
标题:SYNTHESIS OF A HYDRAZONE β-KETO ESTER BY THE REACTION WITH A DIAZO ESTER

专利号:EP-0923540-A1
优先权日:1996-08-30
标 题:Synthesis of a hydrazone beta-keto ester by the reaction with a diazo ester