CAS: 193887-44-4; Fmoc-L-ß-Holeu-Oh
该化合物是一种受保护的氨基酸衍生物,广泛用于固相聚丙酸合成(SPPS),Fmoc(9-氟甲基乙氧碳基)组作为α-氨基功能的临时保护组,在温和的基本条件下有选择地取消保护,β-氢氧化液(β-Holeu-Holeu-OH)系在β定位上引入了氢氧基组,提供了强化的结构性多样性和合成后修改的潜力,这一化合物在合成复杂的peptides中特别有用,因为其侧链功能和立体化学控制是关键因素,在SPPS条件下的高度纯度和稳定性使该组成为pitide化学和药物开发研究人员的可靠建筑块.建议在水条件下进行适当处理以保持再活性.
- 英文名称Fmoc-L-ß-Holeu-Oh
- 中文名称Fmoc-L-β-高亮氨酸
- IUPAC名称(S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-methylhexanoic acid
- 其它别名Hexanoicacid, 3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-5-methyl-, (S)-
- CAS编号193887-44-4
- MFCD编号:MFCD01863059
- EINECS号:888-854-8
- 分子式:C22H25NO4分子量:367.45
- 产品CID: 986904
- 产品分类有机原料→生命科学→氨基酸及其衍生物→亮氨酸及其衍生物
相似化合物
96386-92-4 3653-34-7 132549-43-0物理性质
MSDS等安全信息
- GHS符号GHS07
- 危险类别特定目标器官毒性 - 单次接触 类别3
皮肤腐蚀/刺激 类别2
严重眼刺激 类别2A - 警示词Warning
- 危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激. - 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
- 危险等级IRRITANT
- UN编号NONH for all modes of transport
- 危险品标志Xi
- 安全声明H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- WGK Germany3
欧盟法规
C&L通报上下游产品
CAS号186581-53-3 重氮甲烷 | CAS号35661-60-0 Fm°C-L-亮氨酸 | CAS号103321-59-1 Fm°C-Leu-Cl | CAS号22818-43-5 L-β-高亮氨酸 | CAS号4425-82-5 9-亚甲基-9H-芴合成工艺路线路线简述
- 合成目标产物 Fmoc-L-Beta-Homoleucine 主要起始原料 Fmoc-Leu-Oh
- (文献来源)合成步骤主要原料 Fmoc-Leu-Oh
📜(S)-(S)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-4-Methylpentanoic (Ethyl Carbonic) Anhydride置于水,Silver Benzoate体系中,用 四氢呋喃,1,4-二氧六环,乙醚 用作溶剂,化学反应 3.0H,反应生成芴甲氧羰基-L-β-高亮氨酸
参考文献:Synthesis Of Fmoc-β-Homoamino Acids By Ultrasound-Promoted Wolff Rearrangement
标题:Synthesis Of Fmoc-β-Homoamino Acids By Ultrasound-Promoted Wolff Rearrangement
摘要:A Highly Efficient Protocol For Arndt-Eistert Chain Elongation Of The Base-Labile Fluorenylmethoxycarbonyl (Fmoc) Protected Alpha-Amino Acids By Ag+-Catalyzed,Ultrasound-Promoted Wolff Rearrangement Of The Corresponding Alpha-Diazo Ketones At Room Temperature Is Described. The Enantiomeric Purity Of The Products Was Examined By Capillary Zone Electrophoresis With Chiral Buffer Systems.
Doi:10.1055/s-1998-2075
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2905130000-正丁醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-8410028-B2
优先权日:2003-12-17
标 题:Methods for synthesis of encoded libraries
发明人：MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A
权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC
摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
专利号:US-2007042401-A1
优先权日:2003-12-17
标题 :Methods for synthesis of encoded libraries
专利号:US-2012245040-A1
优先权日:2003-12-17
标题 :Methods for synthesis of encoded libraries
专利号:US-2009062147-A1
优先权日:2003-12-17
标 题:Methods for synthesis of encoded libraries
专利号:US-7972994-B2
优先权日:2003-12-17
标 题 :Methods for synthesis of encoded libraries
专利号:US-7935658-B2
优先权日:2003-12-17
标 题 :Methods for synthesis of encoded libraries
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
[参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.合成参考文献
参考文献:10.1007/s00726-011-0941-z
摘要:Rezaei Araghi R, Baldauf C, Gerling UI, Cadicamo CD, Koksch B. A systematic study of fundamentals in α-helical coiled coil mimicry by alternating sequences of β- and γ-amino acids. Amino Acids. 2011 Aug;41(3):733–42. doi: 10.1007/s00726-011-0941-z.
摘要:Tidwell, T. T., Science of Synthesis, (2006) 23, 585.
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