氯丁烷,三苯基膦氢溴酸盐 以 N,N-二甲基甲酰胺 用作溶剂,化学反应 1.0H,以65%的收率获得丁基三苯基溴化膦 参考文献:Hercouet,A.; Corre,M. Le,Phosphorus And Sulfur And The Related Elements,1987,Vol. 29,P. 111-114 标题:Hercouet,A.; Corre,M. Le,Phosphorus And Sulfur And The Related Elements,1987,Vol. 29,P. 111-114
专利号:US-2008103312-A1 优先权日:2006-08-29 标 题:Processes for the synthesis of 5-phenyl-1-trityl-1H-tetrazole 发明人:KANSAL VINOD K; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; LUNAGARIYA VIJAYKUMAR D 权利人:KANSAL VINOD K; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; LUNAGARIYA VIJAYKUMAR D 摘要:Provided are processes for the synthesis of 5-phenyl-1-trityl-1H-tetrazole, an intermediate useful in the synthesis of irbesartan.
专利号:US-4214099-A 优先权日:1973-10-24 标题:Intermediates for synthesis of precursors for prostaglandins 发明人:BINDRA JASJIT S; COREY ELIAS J; SCHAAF THOMAS K 权利人:PFIZER 摘要:A new synthesis of key prostaglandin precursors and intermediates employed in their preparation. The novel synthetic sequence of this invention is shorter and more efficient than those previously employed to prepare to key intermediate.
专利号:WO-2024105421-A1 优先权日:2022-11-17 标题 :SYNTHESIS OF α,β-UNSATURATED CARBONYLS FROM ALKENES VIA SULFONIUM INTERMEDIATES AND THEIR APPLICATION IN THE SYNTHESIS OF CONJUGATED DIENE PHEROMONES, KAIROMONES, AND RELATED COMPOUNDS 发明人:ANGYAL PÉTER; KOTSCHY ANDRÃ?S MIKLÓS; DUDÃ?S Ã?DÃ?M; SOÓS Tibor; VARGA SZILÃ?RD 权利人:TERMESZETTUDOMANYI KUTATOKOEZPONT; EOETVOES LORAND TUDOMANYEGYETEM 摘要:α,β-Unsaturated aldehydes are useful products as such in agrochemistry, but also potential intermediates for the preparation of important insect pheromones and kairomones. Until now, primarily the thermodynamically more stable (E)-α,β-unsaturated aldehydes have been identified as useful intermediates in the production of conjugated diene pheromone compounds, however, their practical and cost-effective synthesis on an industrial scale remains challenging. The problem to be solved by the present invention is to provide a method for selective oxidation of alkenes to α,β-unsaturated carbonyls which can be further transformed into pheromones and kairomones preferably without isolation and significant loss of the existing stereochemical purity.
专利号:US-5426206-A 优先权日:1993-11-24 标题 :Stereospecific synthesis of aldols 发明人:JUNG MICHAEL E; D AMICO DERIN C 权利人:UNIV CALIFORNIA 摘要:Methods are provided for preparing all four diastereomers of 2-alkyl-3-hydroxyalkanals, 2-alkyl-3-silyloxyalkanals, and the like, with high enantiocontrol, using non-aldol chemistry. The synthetic methods also provide novel, stereospecific routes to polypropinates and chiral 2-substituted-1,3 diols.
专利号:US-8816109-B2 优先权日:2009-01-12 标题:Process for preparation of hexadecyl cis-9-tetradecenoate and hexadecyl cis-10-tetradecenoate 发明人:BETHALA LAKSHMI ANU PRABHAVATHI DEVI; KATKAM NADPI GANGADHAR; KUNKUMA VIJAYALAKSHMI; SISTLA RAMAKRISHNA; KUNCHA MADHUSUDHANA; PRAKASH VAMANRAO DIWAN; RACHAPUDI BADARI NARAYANA PRASAD 权利人:BETHALA LAKSHMI ANU PRABHAVATHI DEVI; KATKAM NADPI GANGADHAR; KUNKUMA VIJAYALAKSHMI; SISTLA RAMAKRISHNA; KUNCHA MADHUSUDHANA; PRAKASH VAMANRAO DIWAN; RACHAPUDI BADARI NARAYANA PRASAD; COUNCIL SCIENT IND RES 摘要:Hexadecyl cis-9-tetradecenoate commonly known as Cetyl myristoleate (CMO) is being used for the treatment of osteoarthritis and other joint inflammatory diseases, cis-9-Tetradecenoic acid (cis-9-myristoleic acid) is the main precursor for the preparation of CMO. As there are limited natural plant sources for cis-9-tetradecenoic acid, the present invention aimed at the synthesis of cis-9-tetradecenoic acid methyl ester from oleic acid methyl ester. As oleic acid is not available in pure form, this has to be isolated from oleic acid-rich oils like olive oil. cis-10-Tetradecenoic acid methyl ester, an isomer of cis-9-tetradecenoic acid was also prepared from undecenoic acid methyl ester, a derivative of castor oil. Undecenoic acid is easily available commercially in pure form. Hexadecyl cis-9-tetradecenoate and hexadecyl c/s-10-tetradecenoate were prepared by enzymatic transesterification of cis-9-tetradecenoic acid methyl ester and cis-10-tetradecenoic acid methyl ester with 1-hexadecanol (cetyl alcohol) respectively. Both the isomers of cetyl myristoleate were evaluated for anti arthritis, blocking inflammation and reduction of adjuvant-induced arthritis in rats.
专利号:EP-4619374-A1 优先权日:2022-11-17 标 题:Synthesis of a-beta-unsaturated carbonyls from alkenes via sulfonium intermediates and their application in the synthesis of conjugated diene pheromones, kairomones, and related compounds
[参考文献]: A J Clark, Et Al. The Measurement Of Membrane Potential During Photosynthesis And During Respiration In Intact Cells Of Rhodopseudomonas Capsulata By Both Electrochromism And By Permeant Ion Redistribution. Biochem J. 1981 Nov 15;200(2):389-97. [参考文献]: C W Keevil, Et Al. Comparison Of Polyvinyl Chloride Membrane Electrodes Sensitive To Alkylphosphonium Ions For The Determination Of The Electrical Difference (Delta Psi) Of Streptococcus Mutans And Lactobacillus Casei. Anal Biochem. 1984 May 15;139(1):228-36. [参考文献]: J E Mccarthy, Et Al. Estimation With An Ion-Selective Electrode Of The Membrane Potential In Cells Of Paracoccus Denitrificans From The Uptake Of The Butyltriphenylphosphonium Cation During Aerobic And Anaerobic Respiration. Biochem J. 1981 Apr 15;196(1):311-21. [参考文献]: Jing Wang, Et Al. Tandem Mass Spectrometric Characterization Of Thiol Peptides Modified By The Chemoselective Cationic Sulfhydryl Reagent (4-Iodobutyl)Triphenylphosphonium--Effects Of A Cationic Thiol Derivatization On Peptide Fragmentation. J Am Soc Mass Spectrom. 2011 Oct;22(10):1771-83.