专利号:US-RE41366-E 优先权日:2001-06-15 标 题 :Total synthesis of galanthamine, analogues and derivatives thereof 发明人:THAL CLAUDE; GUILLOU CATHERINE; BEUNARD JEAN-LUC; GRAS EMMANUEL; POTIER PIERRE 权利人:CT NAT DEL LA RECH SCIENT CNRS 摘要:The invention relates to a method for the synthesis of galanthamine, the derivatives and analogues thereof of formula (1) where R 1 =a hydrogen atom, R 2 =a hydroxy group, R 1 and R 2 together form â•?O, R 3 , R 4 , and R 5 independently=a hydrogen atom, a hydroxy group or a (C 1 -C 2 )alkoxy group, R 6 â•?H, (C 1 -C 12 )alkyl, (CH 2 ) n NR 7 R 8 , or —(CH 2 ) n N + R 7 R 8 R 9 where n=1 to 12, Z=two hydrogen atoms, or an oxygen atom and X=an oxygen, sulphur or nitrogen atom, or a —SO, —SO 2 , or —NR 6 group where R 6 is as defined above or is an amine protecting group.
专利号:WO-2005075497-A1 优先权日:2004-01-07 标 题 :PROCESS FOR THE PREPARATION OF 17ß-SUBSTITUTED-3-OXO-4-AZA-5ALPHA-ANDROSTANE DERIVATIVES 发明人:KUMAR YATENDRA; SINGH RAKESH; KUMAR SARIDI MADHAVA DILEEP; DEO KESHAV; SATHYANARAYANA SWARGAM 权利人:RANBAXY LAB LTD; KUMAR YATENDRA; SINGH RAKESH; KUMAR SARIDI MADHAVA DILEEP; DEO KESHAV; SATHYANARAYANA SWARGAM 摘要:Process for the preparation of 17ß-substituted-3-oxo-4-aza-5α-androstane derivatives, which are useful intermediates for the synthesis of 3-oxo-4-aza-5α-androst-1-ene derivatives including finasteride, is provided.
专利号:US-5760252-A 优先权日:1993-07-20 标 题:Synthetic process for the preparation of tricyclic and tetracyclic taxanes 发明人:HOLTON ROBERT A; SOMOZA CARMEN; KIM HYEONG BAIK; SHINDO MITSURU; BIEDIGER RONALD J; BOATMAN P DOUGLAS; SMITH CHASE; LIANG FENG; MURTHI KRISHNA 权利人:UNIV FLORIDA STATE 摘要:Process for the synthesis of taxol and other tricyclic and tetracyclic taxanes.
专利号:US-6717017-B2 优先权日:1996-08-08 标 题 :Total synthesis of antitumor acylfulvenes 发明人:MCMORRIS TREVOR C 权利人:UNIV CALIFORNIA 摘要:The present invention provides a method of synthesizing compounds of formula (I) or (II): n wherein R 1 is hydrogen, R′ is (C 1 -C 4 )alkyl and X is a hydroxyl protecting group.
专利号:US-6160184-A 优先权日:1996-08-08 标题 :Total synthesis of antitumor acylfulvenes
专利号:US-5723632-A 优先权日:1996-08-08 标 题:Total synthesis of antitumor acylfulvenes