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(E)-3-(P-Tolyl)But-2-Enoic Acid置于氧气,维生素 B2体系中,用 甲醇,乙腈 用作溶剂,化学反应生成4,7-二甲基香豆素
参考文献:一种光催化剂,用于级联催化的 N 活化模式策略:用 (-)-核黄素模拟香豆素生物合成
标题:一种光催化剂,用于级联催化的 N 活化模式策略:用 (-)-核黄素模拟香豆素生物合成
摘要:使用单一催化剂产生分子复杂性,其中必要的活化模式随着反应的进行而依次利用,是合成中一个有吸引力的指导原则.这要求每个底物转位都暴露出一种催化剂活化模式 (Am),所有先前或未来的中间体都对这种模式具有抵抗力.虽然麦克米伦将烯胺和亚胺离子活化的美丽结合体现了这一概念,但当代催化其他领域的例子仍然难以捉摸.在这里,我们将此策略扩展到有机光化学.通过利用 (-)-核黄素的两种离散光化学活化模式,可以分别通过能量转移 (Et) 和单电子转移 (Set) 激活途径依次诱导异构化和环化.这种催化方法已被用于模拟香豆素生物合成途径,该途径具有关键的光化学 E-> Z 异构化步骤.由于随后的基于 Set 的环化消除了对预官能化芳环的需要,这构成了药学重要支架的新断开连接.
Doi:10.1021/jacs.5B12081

专利信息

专利号:US-2007275962-A1
优先权日:2003-09-10
标 题:Heterobicyclic Compounds as Pharmaceutically Active Agents
发明人：KOUL ANIL; KLEBL BERT; MULLER GERHARD; MISSIO ANDREA; SCHWAB WILFRIED; HAFENBRADL DORIS; NEUMANN LARS; SOMMER MARC-NICOLA; MULLER STEFAN; HOPPE EDMUND; FREISLEBEN ACHIM; BACKES ALEXANDER; HARTUNG CHRISTIAN; FELBER BEATRICE; ZECH BIRGIT; ENGKVIST OLA; KERI GYORGY; ORFI LASZLO; BANHEGYI PETER; GREFF ZOLTAN; HORVATH ZOLTAN; VARGA ZOLTAN; MARKO PETER; PATO JANOS; SZABADKAI ISTVAN; SZEKELYHID ZSOLT; WACZEK FRIGYES
权利人:GPC BIOTECH AG
摘要:Described are heterobicyclic compounds such as 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]thiopyran 3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid amides, or benzo[b]thiophene-3-carboxylic acid amides and pharmaceutically acceptable salts thereof, the use of these derivatives for the prophylaxis and/or treatment of various diseases such as infectious diseases, including mycobacteriainduced infections and opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, as well as compositions containing at least one heterobicyclic compound and/or pharmaceutically acceptable salts thereof. Furthermore, reaction procedures for the synthesis of the heterobicyclic compound are disclosed.

专利号:US-7365178-B2
优先权日:2003-04-01
标 题:Acyl-nucleotide probes and methods of their synthesis and use in proteomic analysis
发明人：CAMPBELL DAVID ALAN; LIYANAGE MAREK; SZARDENINGS ANNA KATRIN; WU MIN
权利人:ACTIVX BIOSCIENCES INC
摘要:The present invention provides tagged acyl phosphate probes (“TAPPsâ€?), and methods of their preparation and use. The subject methods and compositions can provide enhanced simplicity and accuracy in identifying changes in the presence, amount, or activity of target proteins in a complex protein mixture, preferably nucleotide binding proteins using nucleotide binding protein-directed TAPPs. The profiling methods described herein can have a number of steps leading to the identification of target nucleotide binding protein(s) in a complex protein mixture.

专利号:US-2022008380-A1
优先权日:2020-07-07
标题:Methods of treating covid-19 pathogenesis
发明人：JACOBSON DANIEL A; PRATES ERICA TEIXEIRA; MILLER JOHN I; GARVIN MICHAEL R
权利人:UT BATTELLE LLC
摘要:This disclosure provides methods for treating a SARS-CoV-2 infection in a subject comprising administering to the subject an effective amount of an inhibitor of COVID-induced RAS imbalance, that downregulates, for example, the Bradykinin system, the Renin-Angiotensin system, the hyaluronan synthesis pathway, or the fibrinogenesis pathway.

专利号:US-2017016040-A1
优先权日:2011-07-21
标题:Chemoenzymatic synthesis of heparin and heparan sulfate analogs

专利号:US-2017204444-A9
优先权日:2011-07-21
标题:Chemoenzymatic synthesis of heparin and heparan sulfate analogs

专利号:US-9290530-B2
优先权日:2011-07-21
标题 :Chemoenzymatic synthesis of heparin and heparan sulfate analogs
发明人：CHEN XI; YU HAI; LAU KAM; BODE LARS
权利人:UNIV CALIFORNIA
摘要:The present invention provides a one-pot multi-enzyme method for preparing UDP-sugars from simple sugar starting materials. The invention also provides a one-pot multi-enzyme method for preparing oligosaccharides from simple sugar starting materials.