CAS: 13204-98-3; Dl-5-Hydroxylysine (Hydrochloride)

该化合物是氨酸碱的衍生物,其特点是,在赖氨酸侧链第5个碳位置上存在一个氢氧基组,该化合物一般是白色的脱白晶粉,在水中溶解,这是许多氨酸衍生物的共同特征.盐酸形式表明,它是盐酸形成的盐,增强了其稳定性和溶解性.赖氨酸本身对于蛋白合成至关重要,并在各种生物过程,包括凝聚物形成和免疫功能中发挥着关键作用.第5位的氢化物可能会产生独特的生物化学特性,有可能影响其与酶和受体的相互作用.与许多氨酸及其衍生物,如甘酸,5-羟基,氢氯化物,可被用于营养补充,医药和研究应用,特别是在与代谢和蛋白结构有关的研究中.

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657-27-2 7274-88-6 70-53-1

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    专利信息


    专利号:US-5824786-A
    优先权日:1996-08-30
    标 题:Synthesis of galactosylhydroxylysine
    发明人：MANOR CHAIM; WEI JIA; MACFARLANE GORDON D
    权利人:INCSTAR CORP
    摘要:Galactosylhydroxylysine is a terminal degradation product of the bone matrix which thus serves as biochemical marker of bone resorption. A method of synthesizing galactosylhydroxylysine is provided. Antibodies against this synthetically prepared galactosylhydroxylysine conjugated to protein carriers were raised to establish methods to measure galactosylhydroxylysine in biological fluids. The antibodies of the invention recognize native galactosylhydroxylysine and are, for example, useful in the measurement of galactosylhydroxylysine as a biochemical marker of bone resorption in biological fluids. Testing of human serum or adolescent urine resulted in dose-dependent increases in signal intensity using the method of the invention.

    专利号:EP-0827963-A2
    优先权日:1996-08-30
    标题 :Synthesis of galactosylhydroxylysine, antibodies to galactosylhydroxylysine, and method of assaying for galactosylhydroxylysine

    专利号:US-11267824-B2
    优先权日:2017-08-17
    标 题:Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase
    发明人：BOSS CHRISTOPH; BUR DANIEL; CREN SYLVAINE; KIMMERLIN THIERRY; LOTZ-JENNE CARINA; POTHIER JULIEN; TIDTEN-LUKSCH NAOMI
    权利人:IDORSIA PHARMACEUTICALS LTD
    摘要:The present invention relates to compounds of Formula (I) inhibiting indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO) enzymes. Further, their synthesis and their use as medicaments in inter alia cancer is disclosed.

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    主要参考文献

    1. van Huizen, N.A., Ijzermans, J.N.M., Burgers, P.C., et al. Collagen analysis with mass spectrometry. Mass Spectrom. Rev. 39(4), 309-335 (2020).
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