专利号:US-7829124-B2 优先权日:2001-04-26 标题:Use of Phyllanthus constituents for treating or preventing infections caused by hepatitis B-viruses 发明人:OTT MICHAEL; MANNS MICHAEL P 权利人:OTT MICHAEL; MANNS MICHAEL P 摘要:The disclosure relates to a method of inhibiting synthesis of viral DNA in a mammal infected with a hepatitis B virus. This method includes administering at least one Phyllanthus component or substance to a mammal infected with the hepatitis B virus. It also includes inhibiting hepatitis B viral DNA synthesis in the mammal using the Phyllanthus component or substance. The disclosure also relates to a method of inhibiting viral gene expression in a mammal infected with a hepatitis B virus. This method includes administering at least one Phyllanthus component or substance to a mammal infected with the hepatitis B virus. It also includes inhibiting expression of at least one hepatitis B viral gene in the mammal using the Phyllanthus component or substance. These methods may form part of a method of preventing or treating hepatitis B infection.
参考文献:10.1021/np50124a006 摘要:Hussain RA, Dickey JK, Rosser MP, Matson JA, Kozlowski MR, Brittain RJ, Webb ML, Rose PM, Fernandes P. A Novel Class of Non-Peptidic Endothelin Antagonists Isolated from the Medicinal Herb Phyllanthus niruri. J. Nat. Prod. 1995 Oct;58(10):1515–20. doi: 10.1021/np50124a006.