CAS: 103-41-3; 3-Phenyl-2-Propenoic Acid Benzyl Ester

相似化合物

140-10-3 621-82-9 91453-04-2

上下游产品

Benzyl acetate benzaldehyde sodium trans-cinnamate benzyl chlorideBenzyl 3-phenylpropionate 3-benzoxy-1-phenyl-1,3-butadiene benzyl 2-(2-furyl)-4-phenyl-1H-pyrrole-3-carboxylate (+/-)-(Z)-1-(dimethylphenylsilyl)-1-phenyl-2-butene

N-(Benzyloxy)Cinnamamide置于间氯过氧苯甲酸,Copper(Ll) Bromide体系中,用 1,4-二氧六环 用作溶剂,化学反应 3.0H,以68%的收率获得肉桂酸苄酯
参考文献:铜介导的n-烷氧基酰胺的氧化均偶联和重排:制备芳族酯的有效方法
标题:铜介导的n-烷氧基酰胺的氧化均偶联和重排:制备芳族酯的有效方法
摘要:N-烷氧基酰胺通过铜催化的氧化均偶联和鹭重排以中等至令人满意的收率成功地转化为其相应的酯.该方法可耐受多种官能团,并允许合成传统酰化化学方法不易获得的位阻酯产物.已经初步提出了自由基介导的途径用于氧化过程.
Doi:10.1016/j.Tetlet.2015.06.023

专利信息

专利号:US-7598291-B2
优先权日:2004-09-02
标题 :Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin
发明人：NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:US-2010160244-A1
优先权日:2004-09-02
标 题 :Methods and compositions for enhancing collagen, proteoglycan, and glutathione synthesis in the skin
发明人：NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:WO-2012089181-A1
优先权日:2010-12-30
标题 :O-substituted (2r,3r)-3-(3-hydroxyphenyl)-2-methyl-4-pentenoic acids and a method of obtaining the same
发明人：VLASAKOVA RUZENA; HAJICEK JOSEF; ZEZULA JOSEF
权利人:ZENTIVA KS; VLASAKOVA RUZENA; HAJICEK JOSEF; ZEZULA JOSEF
摘要:The compounds of general formula II are new and represent important intermediates in the synthesis of tapentadol. In the synthesis of tapentadol of formula I and its pharmaceutically acceptable salts, O-protected (2R,3R)-acids of general formula II, in step A, are reacted in an inert organic solvent with an activating agent, optionally in presence of a catalyst or a base; in step B, the obtained compounds of general formula V, wherein R has the above mentioned meaning and X stands for chlorine or alkoxycarbonyloxyl group O-CO-OR 1 or pivaloyloxyl O-CO-t-Bu group, wherein R 1 is methyl or ethyl, are reacted with dimethylamine or its salts optionally in presence of a base; in step C, the obtained N, N-dimethylamides of general formula VI, wherein R has the above mentioned meaning, are reduced by means of hydride agents in a suitable solvent; in step D, the produced alkeneamines of general formula VII, wherein R has the above mentioned meaning, are hydrogenated on a metal catalysts in a suitable solvent; and, finally, in step E, the produced alkaneamines of general formula VIII, wherein R has the above mentioned meaning, are O-dealkylated by means of dealkylating agents, and, if required, the obtained tapentadol is converted by the action of a pharmaceutically acceptable acid to respective salts, e.g. hydrochloride.

专利号:US-8541598-B2
优先权日:2007-08-21
标 题 :Biodegradable solvents for the chemical industry
发明人：GATHERGOOD NICK; MORRISSEY SAIBH; PEGOT BRUCE
权利人:GATHERGOOD NICK; MORRISSEY SAIBH; PEGOT BRUCE; UNIV DUBLIN CITY
摘要:This invention relates to ionic liquid (ILs) solvents for chemical synthesis based on an alkyl-imidazolium cation core containing ionic liquids which have enhanced biodegradability and reduced toxicity relative to existing imidazolium bases ILs such as 1-butyl-3-methylimidazolium (bmmim) salts. Many of the described ILs produce a score of over 60% biodegradability over 28 days in a biodegradability test such as the Sturm Test, the Closed Bottle Test (OECD 301D) or the CO 2 Headspace Test (ISO 14593). The ILs of the invention comprise an alkyl substituted imidazolium cationic core having a —Câ•?OX— side chain in the 3-position of the imidazole ring, wherein Xâ•?O, NH, N or S and an associated counteranion characterized in that the —Câ•?OX side chain comprises at least one ether linkage. The biodegradable and non-toxic IL may be used as green solvents for the chemical, pharmaceutical, biofuel and biomass industries. The ILs of the invention are particularly useful in hydrogenation, pericyclic ad metathesis reactions.

专利号:US-2015079138-A1
优先权日:2012-01-31
标题:UV Protection Agent Based on Bismuth Oxychloride
发明人：BEREA LAGARDA GUSTAVO ADOLFO; BEREA MONTES EDGARDO; PARRA CERVANTES PATRICIA; SOTO VAZQUEZ RAMON; ROMERO CASTELLO SAMUEL
权利人:FARMAQUIMIA S A DE C V
摘要:Provided herein is a Bismuth inorganic salt, specifically, Bismuth Oxychloride useful as a sun protection agent, and to the synthesis methods to obtain optimized Bismuth Oxychloride with specific photoprotecting features ensuring optimum stability, effectiveness and safety for the protection against skin and/or hair, and/or facial hair, and/or body hair damage caused by UV solar radiation. Furthermore, different compositions with effective and safe concentrations of Bismuth Oxychloride are described. These compositions exhibit protection values above those commonly obtained from organic and inorganic agents known in the state of the art, all along the ultraviolet spectrum (290 to 400 nm). This physically and chemically characterized compound, with critical wavelengths above 380 nm, is a “broad spectrumâ€? sunscreen.

专利号:US-8785655-B2
优先权日:2009-02-25
标 题:Ionic liquid solvents
发明人：GATHERGOOD NICHOLAS; PEGOT BRUCE; BEADHAM IAN; GURBISZ MONIKA; GHAVRE MUKUND D; MORRISSEY SAIBH
权利人:GATHERGOOD NICHOLAS; PEGOT BRUCE; BEADHAM IAN; GURBISZ MONIKA; GHAVRE MUKUND D; MORRISSEY SAIBH; UNIV DUBLIN CITY
摘要:A chiral ionic compound comprising an alkyl substituted imidazolium or pyridinium cationic core having an alkyl ester side chain (-alkyl-C(O)O—) directly linked to the core and an associated counter anion, characterized in that the —O— atom of the ester side chain is linked to an alpha, a beta or a gamma hydroxycarboxylic acid functionality via the alpha, beta or gamma hydroxy of the acid functionality and the hydroxycarboxylic acid functionality has at least one asymmetric carbon, or characterized in that an —Nâ•? atom of the alkyl substituted imidazolium or pyridinium cationic core is substituted with an alpha, a beta or a gamma hydroxy group of a alpha, a beta or a gamma hydroxycarboxylic acid functionality and the hydroxycarboxylic acid functionality has at least one asymmetric carbon. The chiral ionic liquids (CILs) may be used as novel solvents, in particular for organic synthesis. The CILs have the potential to induce asymmetry into substrates or catalysts in a variety of organic transformations. A number of the compounds have low antimicrobial and low antifungal toxicities and are aso biodegradable CILs.