CAS: 937-14-4; 3-Chloroperbenzoic Acid

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CAS号535-80-8 间氯苯甲酸 | CAS号618-46-2 间氯苯甲酰氯 | CAS号18791-75-8 4-溴-2-噻吩甲醛 | CAS号624-92-0 二甲基二硫醚 | CAS号110674-74-3 1,4,9-trioxaspi... | CAS号35139-67-4 2,6-二氨基-4-氯嘧啶-1-氧化物 | CAS号4911-65-3 3-氯丙基苯基硫醚 | CAS号3466-32-8 4-溴苯甲砜 | CAS号502-44-3 ε-己内酯 | CAS号108-94-1 环己酮 | CAS号108-90-7 氯苯 | CAS号108-93-0 环己醇 | CAS号90357-06-5 比卡鲁胺 | CAS号111-87-5 正辛醇

间氯苯甲酰胺置于sodium Nitrite,N-溴代乙酰胺,Zinc Fluoride,水体系中,化学反应 6.17H,以98.7%的收率获得产物间氯过氧苯甲酸
参考文献:间氯过氧苯甲酸药物中间体的合成方法
标题:间氯过氧苯甲酸药物中间体的合成方法
摘要:本发明公开了间氯过氧苯甲酸药物中间体的合成方法,包括如下步骤:在反应容器中加入间氯苯乙酰胺,硝酸钠溶液,控制搅拌速度230‑260Rpm,溶液温度至10‑16°C,加入甲基正丁基醚溶液,1,4‑丁二醇溶液,在20‑40Min内分批次加入n‑溴代乙酰胺,继续反应60‑90Min;然后加入水溶液,氟化锌粉末,控制搅拌速度310‑330Rpm,继续反应3‑4H,加入氯化钠溶液洗涤30‑50Min,3‑庚醇溶液洗涤20‑40Min,在硝基乙烷溶液中重结晶,脱水剂脱水,得成品间氯过氧苯甲酸.

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-2007287843-A1
优先权日:2004-04-07
标题 :Methods and Intermediates for the Synthesis of Delta-9 Tetrahydrocannabinol
发明人：CABAJ JOHN E; PARIZA RICHARD J; LUKESH JULIE M
权利人:CABAJ JOHN E; PARIZA RICHARD J; LUKESH JULIE M
摘要:Processes are disclosed for the synthesis of Delta-9 tetrahydrocannabinol which result in an improved Y-THC/Y-THC ratio, and intermediates are disclosed that may be used in the synthesis of Delta-9 tetrahydrocannabinol such that improved Y-THCIY-THC ratios are achieved. The intermediates may be cyclic compounds prepared from 2-Carene. There is also provided a scaleable process for the preparation of (+)-p-menth-2-ene-1,8-diol, another intermediate used in the synthesis of delta-9-tetrahydrocannibinol.

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-2016031800-A1
优先权日:2013-03-14
标 题:Synthesis of chiral kynurenine compounds and intermediates
发明人：TRETYAKOV ALEXANDER; DROUET KEITH E; SANDERS WILLIAM
权利人:VISTAGEN THERAPEUTICS INC
摘要:Provided are methods for the synthesis of compounds including chiral kynurenine compounds, intermediates useful for the synthesis thereof, and related compounds. For example, methods are provided for the synthesis of L-4-chlorokynurenine.

专利号:WO-2021035382-A1
优先权日:2019-08-23
标题:Method forcontinuous synthesis of 2-cyclopentene-1-one
发明人：HONG HAO; LU JIANGPING; BAO DENGHUI; YUAN LONG; WANG BO
权利人:LIAONING ASYMCHEM LABORATORIES CO LTD
摘要:Provided is a method for the continuous synthesis of 2-cyclopenten-1-one. The continuous synthesis method comprises: loading a catalyst in a continuous reaction device, then continuously conveying cyclopentene, an oxidant and a solvent into the continuous reaction device for an oxidation reaction, and continuously discharging 2-cyclopentene-1-one. In the presence of the catalyst and the solvent, cyclopentene is used as a starting material, and same is directly oxidized by the oxidant, which can avoid the generation of a large amount of halogen-containing three wastes; at the same time, the entire continuous synthesis process is carried out in the continuous reaction device, which can effectively inhibit the occurrence of safety risks during scale-up production; in addition, after the reaction is complete, the product system of the oxidation reaction can be simply concentrated to obtain the target product (2-cyclopenten-1-one). Thus, the purity (up to 98% and above) and separation rate (up to 79%) of the product are greatly improved, and production can be easily scaled up.

专利号:US-4351767-A
优先权日:1981-06-29
标题 :Synthesis of 24,25-dihydroxycholesterol
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:This invention relates to the synthesis of steroids which are useful for their biological activity or which may be converted to steroids which have such activity. More particularly, the invention pertains to the synthesis of 24,25-dihydroxycholesterol. It includes intermediate sterols of this synthesis and processes for their preparation.