CAS: 86933-75-7; Neurokinin B (Human, Porcine)
- 英文名称Neurokinin B (Human, Porcine)
- 中文名称神经激肽B
- IUPAC名称(5S,8S,14S,17S,20S,23S,26S,29S,32S)-26-((1H-imidazol-4-yl)methyl)-32-amino-17,20-dibenzyl-5-carbamoyl-23-(carboxymethyl)-8-isobutyl-14-isopropyl-29-(2-(methylthio)ethyl)-7,10,13,16,19,22,25,28,31-nonaoxo-2-thia-6,9,12,15,18,21,24,27,30-nonaazatetratriacontan-34-oic acid
- 其它别名Kassinin,2-L-methionine-3-L-histidine-4-de-L-lysine-5-de-L-serine-7-L-phenylalanine-; L-Methioninamide, L-a-aspartyl-L-methionyl-L-histidyl-L-a-aspartyl-L-phenylalanyl-L-phenylalanyl-L-valylglycyl-L-leucyl-; Neurokinin B (human); Neurokinin B (pig spinal cord); Neurokinin B (porcine); Neurokinin b; Neurokinin b (pig spinal cord); Neuromedin K; Neuromedin K (pig spinal cord); Porcine neurokinin B; Zneurok1 (human)
- CAS编号86933-75-7
- MFCD编号:MFCD00133665
- 分子式:C55H79N13O14S2分子量:1210.42
- 产品CID: 1873006
- 产品分类生物化工 → 多肽
- 相似结构搜索
- 产品信息参考
- InChIKey: NHXYSAFTNPANFK-HDMCBQFHSA-N
- NHXYSAFTNPANFK-KWRJECPGNA-N
- 计算化学: 氢键受体数27.0氢键供体数14.0可旋转键数47.0
物理性质
合成工艺路线路线简述
- 86933-75-7 = 86933-75-7
反应条件:1.1 Reagents: Trifluoroacetic Acid,Triisopropylsilane Solvents: Water; 2 H,Rt
标题:N-Terminus Fitc Labeling Of Peptides On Solid Support: The Truth Behind The Spacer
作者:Jullian,Magali; Et Al
参考文献:Tetrahedron Letters 日期:2009 卷标:50(3) 页码:260-263]
71989-28-1 + 119062-05-4 + 29022-11-5 + 116611-64-4 + 68858-20-8 + 35661-60-0 + 35661-40-6 = 86933-75-7 [标题:Reaction Conditions
标题:Structure-Activity Relationship Study Of Neurokinin-3 Receptor Agonists
作者:Noguchi,Taro; Et Al
参考文献:Peptide Science 日期:2013 卷标:49 页码:189-190]
86933-75-7 + 97185-84-7 = 86933-75-7
反应条件:1.1 Reagents: 4-Methylmorpholine,3-[[(4-Methoxyphenyl)Methyl]Thio]-1-(2-Thioxo-3-Thiazolidinyl)-1-Propanone1.2 Reagents: Thioanisole,Trifluoromethanesulfonic Acid Solvents: Trifluoroacetic Acid1.3 Solvents: Dimethylformamide,Water1.4 Reagents: 4-Methylmorpholine Solvents: Dimethylformamide,Water
标题:Studies On Peptides. Cxxviii. Application Of New Heterobifunctional Crosslinking Reagents For The Preparation Of Neurokinin (A And B)-Bsa (Bovine Serum Albumin) Conjugates
作者:Fujii,Nobutaka; Et Al
参考文献:International Journal Of Peptide & Protein Research 日期:1985 卷标:26(2) 页码:121-9
📜在 氢氟酸,苯甲醚体系中,用 二甲基亚砜作为反应溶剂,反应 1.0H,获得 Neurokinin B
参考文献:神经激肽α和β,合成和药理特性
标题:神经激肽α和β,合成和药理特性
摘要:通过溶液法化学合成从猪脊髓中分离出的两种新型神经肽,神经激肽α和β.所提出的氨基酸序列被证实是正确的,并研究了神经激肽肽的药理特性.
Doi:10.1246/Cl.1984.1013
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2905130000-正丁醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-9723455-A1
优先权日:1995-12-21
标 题 :Processes for preparing non-peptidyl tachykinin receptor antagonists
发明人：CHELIUS ERIK C; KJELL DOUGLAS P; LORENZ KURT T
权利人:LILLY CO ELI; CHELIUS ERIK C; KJELL DOUGLAS P; LORENZ KURT T
摘要:This invention provides novel processes for preparing a compound of formula (I) which comprises reacting a compound of formule (II) with water and hydrochloric acid. This invention also provides processes for preparing the intermediate depicted above as well as a novel intermediate in this synthesis.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Dornan WA, Vink KL, Malen P, Short K, Struthers W, Barrett C. Site-specific effects of intracerebral injections of three neurokinins (neurokinin A, neurokinin K, and neurokinin gamma) on the expression of male rat sexual behavior. Physiol Behav. 1993 Aug;54(2):249-58. doi: 10.1152/jn.00980.2015. Epub 2016 Feb 3.
3: Deacon CF, Agoston DV, Nau R, Conlon JM. Conversion of neuropeptide K to neurokinin A and vesicular colocalization of neurokinin A and substance P in neurons of the guinea pig small intestine. J Neurochem. 1987 Jan;48(1):141-6. pii: pyw023. doi: 10.1093/ijnp/pyw023. Print 2016 Aug.
5: Jansen I, Alafaci C, McCulloch J, Uddman R, Edvinsson L. Tachykinins (substance P, neurokinin A, neuropeptide K, and neurokinin B) in the cerebral circulation: vasomotor responses in vitro and in situ. J Cereb Blood Flow Metab. 1991 Jul;11(4):567-75. doi: 10.2108/zs150081. Epub 2016 Jul 26. Erratum in: J Biol Chem. 1991 Jan 15;266(2):1354. Epub 2016 Sep 16.
合成参考文献
参考文献:10.1007/s002100100447
摘要:Giuliani S, Santicioli P, Lippi A, Lecci A, Tramontana M, Maggi CA. The role of sensory neuropeptides in motor innervation of the hamster isolated urinary bladder. Naunyn Schmiedebergs Arch Pharmacol. 2001 Sep;364(3):242–8. doi: 10.1007/s002100100447.
参考文献:10.1007/s002100100427
摘要:Vieira C, Fetzer S, Sauer SK, Evangelista S, Averbeck B, Kress M, Reeh PW, Cirillo R, Lippi A, Maggi CA, Manzini S. Pro- and anti-inflammatory actions of ricinoleic acid: similarities and differences with capsaicin. Naunyn Schmiedebergs Arch Pharmacol. 2001 Aug;364(2):87–95. doi: 10.1007/s002100100427.
参考文献:10.1007/s10384-005-0314-9
摘要:Ebihara N, Nishikawa M, Murakami A. Disodium Cromoglycate Inhibits Capsaicin-Induced Eosinophil Infiltration of Conjunctiva Independent of Mast Cells. Japanese Journal of Ophthalmology. 2006 May;50(3):205–10. doi: 10.1007/s10384-005-0314-9.
参考文献:10.1007/s10540-006-9014-z
摘要:Sankararamakrishnan R. Recognition of GPCRs by peptide ligands and membrane compartments theory: structural studies of endogenous peptide hormones in membrane environment. Biosci Rep. 2006 Apr;26(2):131–58. doi: 10.1007/s10540-006-9014-z.
参考文献:10.1007/s00213-008-1119-6
摘要:Nordquist RE, Delenclos M, Ballard TM, Savignac H, Pauly-Evers M, Ozmen L, Spooren W. Cognitive performance in neurokinin 3 receptor knockout mice. Psychopharmacology (Berl). 2008 Jun;198(2):211–20. doi: 10.1007/s00213-008-1119-6.
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