CAS: 854778-31-7; (4-Fluoro-3-Methoxyphenyl)Boronic Acid

该化合物是一种多用途的boronic 衍生物,广泛用于铃木-Miyaura交叉组合反应,这是有机合成中形成碳-碳联系的关键方法.氟和甲氧替代成分的存在增强了其反应性和选择性,使其在制药和农用化学应用中具有价值.该化合物在标准条件下具有良好稳定性,并表现出与各种催化剂高度兼容性.其结构特征使得芳香系统能够高效地功能化,能够合成复杂的分子.产品通常作为白色的,白色的,非白的,纯度高的晶状固体供应,确保了要求高的合成协议的可靠性能.

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4-bromo-1-fluoro-2-methoxy-benzene 7H6BF4O(1-)C7H6BF4O(1-) 5-{2-[2-chloro-4-(4-fluoro-3-methoxy-phenoxy)-phenyl]-1-hydroxy-1-trifluoromethyl-propyl}-1-methyl-1H-pyridin-2-one

合成工艺路线路线简述

    Trifluoro-(4-Fluoro-3-Methoxyphenyl)Boranuide 以 Phosphate Buffer 作为反应溶剂,化学反应生成 4-氟-3-甲氧基苯硼酸
    参考文献:Substituent Effects On Aryltrifluoroborate Solvolysis In Water: Implications For Suzuki−miyaura Coupling And The Design Of Stable 18F-Labeled Aryltrifluoroborates For Use In Pet Imaging
    标题:Substituent Effects On Aryltrifluoroborate Solvolysis In Water: Implications For Suzuki−miyaura Coupling And The Design Of Stable 18F-Labeled Aryltrifluoroborates For Use In Pet Imaging
    摘要:Whereas Electron Withdrawing Substituents Retard The Rate Of Aryltrifluoroborate Solvolysis,Electron-Donating Groups Enhance It. Herein Is Presented A Hammett Analysis Of The Solvolytic Lability Of Aryltrifluoroborates Where Log(K(Solv)) Values Correlate To Sigma Values With A Rho Value Of Approximately-1. This Work Provides A Predictable Rubric For Tuning The Reactivity Of Boron For Several Uses Including F-18-Labeled Pet Reagents And Has Mechanistic Implications For Arbf3-Enhanced Ligandless Metal-Mediated Cross Coupling Reactions With Aryltrifluoroborates.
    DOI:10.1021/jo800681D

    海关参考信息

    专利信息


    专利号:US-2024215280-A1
    优先权日:2022-10-31
    标 题:In situ core/shell perovskite nanocrystal material, method of preparation thereof, and light emitting device comprising the same
    发明人:LEE TAE-WOO; KIM JOO SUNG
    权利人:SEOUL NAT UNIV R&DB FOUNDATION; PEROLED CO LTD
    摘要:The present inventive concept relates to an in situ core/shell perovskite nanocrystal film formed by an in situ nanocrystal synthesis process, a method for producing the same, and a light emitting device comprising the same as a light-emitting layer. The in situ core/shell perovskite nanocrystal film formed by the in situ nanocrystal synthesis process according to the present inventive concept exhibits a strong charge confinement effect by nanocrystal formation, and can simultaneously greatly improve the luminescence efficiency and lifetime by maintaining the fast charge transport capability of polycrystalline perovskite.

    专利号:US-2025092058-A1
    优先权日:2018-09-17
    标 题 :Matter of composition, synthesis, formulation and application of fl 118 platform positions 7 and 9-derived analogues for treatment of human disease
    发明人:LING XIANG; LI QINGYONG; LI FENGZHI
    权利人:CANGET BIOTEKPHARMA LLC
    摘要:Described herein, are the chemical synthesis, compounds, methods and uses of the fluoroaryl-substituted derivatives at the FL118 position 7, which target multiple cellular human disease-relevant proteins and their signaling pathways.

    专利号:US-12150934-B2
    优先权日:2016-11-30
    标 题 :Methods of using substituted pyrazole and pyrazole compounds and for treatment of hyperproliferative diseases
    发明人:SIDDIQUI ARSHAD M; CIBLAT STEPHANE; CONSTANTINEAU-FORGET LEA; GRAND-MAITRE CHANTAL; GUO XIANGYU; SRIVASTAVA SANJAY; SHIPPS GERALD W; COOPER ALAN B; OZA VIBHA; KOSTURA MATTHEW W; LUTHER MICHAEL; LEVINE JEDD
    权利人:BANTAM PHARMACEUTICAL LLC
    摘要:Disclosed are methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formula (I), in which X1, X2, Z1, Z2, the ring system denoted by “aâ€?, R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.

    专利号:US-2024158692-A1
    优先权日:2022-10-31
    标题 :In-situ core/shell nanoparticle structured metal halide perovskite luminescent material, light emitting device including the same, and manufacturing method thereof
    发明人:LEE TAE-WOO; KIM JOO SUNG
    权利人:SEOUL NAT UNIV R&DB FOUNDATION; PEROLED CO LTD
    摘要:The present inventive concept relates to an in situ core/shell perovskite nanocrystal film formed by an in situ nanocrystal synthesis process, a method for producing the same, and a light emitting device comprising the same as a light-emitting layer. The in situ core/shell perovskite nanocrystal film formed by the in situ nanocrystal synthesis process according to the present inventive concept exhibits a strong charge confinement effect by nanocrystal formation, and can simultaneously greatly improve the luminescence efficiency and lifetime by maintaining the fast charge transport capability of polycrystalline perovskite.
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    合成参考文献


    摘要:Zhang, F.-G.; Ma, J.-A., Science of Synthesis: Knowledge Updates, (2025) 2.
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