Trifluoro-(4-Fluoro-3-Methoxyphenyl)Boranuide 以 Phosphate Buffer 作为反应溶剂,化学反应生成 4-氟-3-甲氧基苯硼酸 参考文献:Substituent Effects On Aryltrifluoroborate Solvolysis In Water: Implications For Suzuki−miyaura Coupling And The Design Of Stable 18F-Labeled Aryltrifluoroborates For Use In Pet Imaging 标题:Substituent Effects On Aryltrifluoroborate Solvolysis In Water: Implications For Suzuki−miyaura Coupling And The Design Of Stable 18F-Labeled Aryltrifluoroborates For Use In Pet Imaging 摘要:Whereas Electron Withdrawing Substituents Retard The Rate Of Aryltrifluoroborate Solvolysis,Electron-Donating Groups Enhance It. Herein Is Presented A Hammett Analysis Of The Solvolytic Lability Of Aryltrifluoroborates Where Log(K(Solv)) Values Correlate To Sigma Values With A Rho Value Of Approximately-1. This Work Provides A Predictable Rubric For Tuning The Reactivity Of Boron For Several Uses Including F-18-Labeled Pet Reagents And Has Mechanistic Implications For Arbf3-Enhanced Ligandless Metal-Mediated Cross Coupling Reactions With Aryltrifluoroborates. DOI:10.1021/jo800681D
专利号:US-2024215280-A1 优先权日:2022-10-31 标 题:In situ core/shell perovskite nanocrystal material, method of preparation thereof, and light emitting device comprising the same 发明人:LEE TAE-WOO; KIM JOO SUNG 权利人:SEOUL NAT UNIV R&DB FOUNDATION; PEROLED CO LTD 摘要:The present inventive concept relates to an in situ core/shell perovskite nanocrystal film formed by an in situ nanocrystal synthesis process, a method for producing the same, and a light emitting device comprising the same as a light-emitting layer. The in situ core/shell perovskite nanocrystal film formed by the in situ nanocrystal synthesis process according to the present inventive concept exhibits a strong charge confinement effect by nanocrystal formation, and can simultaneously greatly improve the luminescence efficiency and lifetime by maintaining the fast charge transport capability of polycrystalline perovskite.
专利号:US-2025092058-A1 优先权日:2018-09-17 标 题 :Matter of composition, synthesis, formulation and application of fl 118 platform positions 7 and 9-derived analogues for treatment of human disease 发明人:LING XIANG; LI QINGYONG; LI FENGZHI 权利人:CANGET BIOTEKPHARMA LLC 摘要:Described herein, are the chemical synthesis, compounds, methods and uses of the fluoroaryl-substituted derivatives at the FL118 position 7, which target multiple cellular human disease-relevant proteins and their signaling pathways.
专利号:US-12150934-B2 优先权日:2016-11-30 标 题 :Methods of using substituted pyrazole and pyrazole compounds and for treatment of hyperproliferative diseases 发明人:SIDDIQUI ARSHAD M; CIBLAT STEPHANE; CONSTANTINEAU-FORGET LEA; GRAND-MAITRE CHANTAL; GUO XIANGYU; SRIVASTAVA SANJAY; SHIPPS GERALD W; COOPER ALAN B; OZA VIBHA; KOSTURA MATTHEW W; LUTHER MICHAEL; LEVINE JEDD 权利人:BANTAM PHARMACEUTICAL LLC 摘要:Disclosed are methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formula (I), in which X1, X2, Z1, Z2, the ring system denoted by “aâ€?, R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.
专利号:US-2024158692-A1 优先权日:2022-10-31 标题 :In-situ core/shell nanoparticle structured metal halide perovskite luminescent material, light emitting device including the same, and manufacturing method thereof 发明人:LEE TAE-WOO; KIM JOO SUNG 权利人:SEOUL NAT UNIV R&DB FOUNDATION; PEROLED CO LTD 摘要:The present inventive concept relates to an in situ core/shell perovskite nanocrystal film formed by an in situ nanocrystal synthesis process, a method for producing the same, and a light emitting device comprising the same as a light-emitting layer. The in situ core/shell perovskite nanocrystal film formed by the in situ nanocrystal synthesis process according to the present inventive concept exhibits a strong charge confinement effect by nanocrystal formation, and can simultaneously greatly improve the luminescence efficiency and lifetime by maintaining the fast charge transport capability of polycrystalline perovskite.