CAS: 766-36-9; 3-Ethyl-4-Methyl-2,5-Dihydro-1H-Pyrrol-2-One

相似化合物

766-45-0 20189-42-8 4030-22-2

上下游产品

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2-乙基乙酰乙酸乙酯置于t-1 Raney Nickel 氢气,乙酸酐,Sodium Carbonate,Sodium Hydrogensulfite体系中,化学反应 19.0H,反应生成 3-乙基-4-甲基-3-吡咯啉-2-酮
参考文献:Diastereoselective Synthesis Of Phycocyanobilin-Cysteine Adducts
标题:Diastereoselective Synthesis Of Phycocyanobilin-Cysteine Adducts
摘要:Methodology Is Presented For The Synthesis Of Two Diastereomers Of A Cysteine-Linked Phycocyanobilin Derivative. The Crucial Reaction Is A Diastereoselective 1,6-Michael Addition Of Cysteine Methyl Ester To An Appropriate Dihydropyrromethenone Educt. The Diastereomers So Generated Were Then Elaborated To Two Phycocyanobilin Trimethyl Esters. Definitive Assignments Of Relative Stereochemistry,Double Bond Geometry,And Solution Conformation Are Accomplished By Application Of Roesy NMR Experiments,While Absolute Stereochemical Assignments Are Based On Degradation To Compounds Of Known Chirality.
DOI:10.1021/ja00021A032

专利信息

专利号:US-2007082943-A1
优先权日:2005-04-01
标 题:Process for preparation of substantially pure glimepiride
发明人：KADAM SURESH M; TARUR VENKATASUBRAMANIAN R; NAIK SANJAY J; GAVHANE SACHIN B
权利人:KADAM SURESH M; TARUR VENKATASUBRAMANIAN R; NAIK SANJAY J; GAVHANE SACHIN B
摘要:The present invention discloses a novel process for purification of trans-4-methyl cyclohexylamine HCl and 4[-2-(3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl] benzene sulfonamide used in the synthesis of 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methyl cyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide (I), popularly known as Glimepiride. The present invention also discloses a novel purification of Glimepiride usingS methanolic ammonia and glacial acetic acid to obtain highly pure Glimepiride Form I (I) having the undesired cis isomer below 0.15%. Glimepiride (I) is useful in the treatment of diabetes mellitus.

专利号:CN-108383768-A
优先权日:2018-04-13
标 题 :A kind of glimepiride crude drug synthesis process

专利号:CN-101693200-A
优先权日:2009-10-23
标 题:Catalyst for synthesizing key intermediate of glimepiride and synthesis method thereof

专利号:RU-2195459-C2
优先权日:1996-11-14
标 题:3-amido-chromanylsulfonyl(thio)ureas, method of their synthesis and pharmaceutical composition based on thereof