CAS: 65896-11-9; 2-Bromo-6-Fluoroaniline

上下游产品

CAS号348-54-9 邻氟苯胺 | CAS号886762-70-5 2-溴-6-氟硝基苯 | CAS号450412-29-0 2-溴-6-氟碘苯

2-氟苯胺置于氢溴酸,二甲基亚砜体系中,用 乙酸乙酯 作为反应溶剂,化学反应 12.0H,反应生成 2-溴-6-氟苯胺
参考文献:从简单化学品直接合成结构不同的吲哚生物碱
标题:从简单化学品直接合成结构不同的吲哚生物碱
摘要:已开发出一种新颖的底物裂解/环加成策略,可从非常简单的2-乙烯基苯胺,炔烃和tbn直接合成并在结构上多样化的吲哚生物碱,这提供了一种无贵金属的有效方法,可访问高度有价值的吲哚衍生物库包括色胺和色胺相关的肟,内酰胺和内酯,以及β-咔啉,螺二吲哚和六氢吡咯并[2,3-B]吲哚.
DOI:10.1002/cjoc.201800258

专利信息

专利号:US-2025188046-A1
优先权日:2023-12-08
标题:Ultrafast flow synthesis of functionalized sulfonyl fluorides and subsequent sufex connections via lithiated chemistry
发明人：KIM DONG-PYO; KANG JI-HO
权利人:POSTECH RES & BUSINESS DEV FOUND
摘要:Disclosed are ultrafast flow synthesis of functionalized sulfonyl fluorides and subsequent SuFEx connections via lithiated chemistry. In detail, a method of synthesizing an ortho-functionalized benzenesulfonyl fluoride derivative, the method comprises (a) reacting a benzenesulfonyl fluoride derivative represented by structural formula 1 with an organolithium represented by structural formula 2, thus synthesizing an intermediate represented by structural formula 3 in reaction scheme 1 and (b) reacting the intermediate with an electrophile, thus synthesizing a compound represented by structural formula 4 or a compound represented by structural formula 4′. The present disclosure enables the synthesis of several functionalized sulfonyl fluorides within a few seconds under mild temperature conditions in addition to the chemistry of Sulfonyl Fluoride Exchange (SuFEx), which is a next-generation click chemistry, so that sulfonyl fluoride, the main reactant of the SuFEx reaction, can be efficiently secured.