CAS: 60218-41-9; 2-Enevalproicacid

该化合物是一种不饱和的箱状碳酸,其特点是α,β-不饱和结构,这种结构在有机合成和制药应用中提供了有用的再活性.pent-2-蛋白酸脊骨,加上2丙基替代体,影响其物理化学特性,包括酸性和溶性.该化合物可作为合成更复杂的分子的中间体,特别是在药用化学中,这种结构常常被探索为生物活性潜力.其相交的双重结合系统允许参与Michael的添加和其他核生殖反应,使其成为精细化学生产的一个多功能建筑块.由于潜在的再活动,建议适当处理.

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636-82-8 1560-11-8 33786-47-9

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CAS号3639-22-3 2-hydroxy-2-pro...

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    专利号:US-6605430-B1
    优先权日:1998-08-12
    标题 :DNA shuffling of monooxygenase genes for production of industrial chemicals
    发明人：AFFHOLTER JOSEPH A; DAVIS S CHRISTOPHER; SELIFONOV SERGEY A
    权利人:MAXYGEN INC
    摘要:This invention provides improved monoxygenases, dehydrogenases, and transferases that are useful for the biocatalytic synthesis of compounds such as α-hydroxycarboxylic acids, and aryl- and alkyl-hydroxy compounds. The polypeptides provided herein are improved in properties such as regioselectivity, enzymatic activity, stereospecificity, and the like. Methods for obtaining recombinant polynucleotides that encode these improved polypeptides are also provided, as are organisms that express the polypeptides and are thus useful for carrying out said biocatalytic syntheses. Also provided by the invention are methods for increasing said solvent resistance of organisms that are used in the synthetic methods.

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    合成参考文献


    参考文献:10.1016/0920-1211(92)90052-u
    摘要:Löscher W, Wahnschaffe U, Hönack D, Wittfoht W, Nau H. Effects of valproate and E-2-en-valproate on functional and morphological parameters of rat liver. I. Biochemical, histopathological and pharmacokinetic studies. Epilepsy Res. 1992 Dec;13(3):187–98. doi: 10.1016/0920-1211(92)90052-u.
    参考文献:10.1007/bf01962705
    摘要:Löscher W. Pharmacological, toxicological and neurochemical effects of Δ2(E)-valproate in animals. Pharmaceutisch Weekblad Scientific Edition. 1992 Jun;14(3):139–43. doi: 10.1007/bf01962705.
    参考文献:10.1007/bf01962707
    摘要:Fabre G, Briot C, Marti E, Montseny J-, Bourrié M, Massé D, Berger Y, Cano J-. Δ2-Valproate biotransformation using human liver microsomal fractions. Pharmaceutisch Weekblad Scientific Edition. 1992 Jun;14(3):146–51. doi: 10.1007/bf01962707.
    参考文献:10.1007/bf01962708
    摘要:Düsing RH. Single-dose tolerance and pharmacokinetics of 2-n-propyl-2(E)-pentenoate (Δ2(E)-valproate) in healthy male volunteers. Pharmaceutisch Weekblad Scientific Edition. 1992 Jun;14(3):152–8. doi: 10.1007/bf01962708.
    参考文献:10.1007/bf01962709
    摘要:Gram L. Studies on 2-n-propyl-2(E)-pentenoate (Δ2(E)-valproate) in man. Pharmaceutisch Weekblad Scientific Edition. 1992 Jun;14(3):159–60. doi: 10.1007/bf01962709.
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