CAS: 543-27-1; Isobutyl Chloroformate

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CAS号78-83-1 异丁醇 | CAS号32315-10-9 三光气 | CAS号75-44-5 光气 | CAS号3178-22-1 叔丁基环已烷 | CAS号7058-01-7 2-环己基丁烷 | CAS号55-21-0 苯甲酰胺 | CAS号143540-05-0 1,4-双(B°C)-2-哌嗪甲醇 | CAS号15196-02-8 ZL-Phe-CHN2 | CAS号110592-42-2 B°C-p-Benzoyl-L... | CAS号4248-19-5 氨基甲酸叔丁酯 | CAS号925437-85-0 3-羟基甲基-6-(2-硝基苯... | CAS号940868-17-7 1-Cbz-哌啶-2-甲酰胺

Carbonic Acid Monoisobutyl Ester置于草酰氯,N,N-二甲基甲酰胺体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 氯甲酸异丁酯
参考文献:羧酸合成 N-三氟甲基酰胺
标题:羧酸合成 N-三氟甲基酰胺
摘要:在生物分子,药物和农用化学品中发现的含酰胺分子在自然界中无处不在,它们的衍生化代表了氟化学的重要方法学目标.三氟甲基酰胺已成为药物化合物中常见的重要官能团.迄今为止,还没有从丰富的有机羧酸衍生物合成n-三氟甲基酰胺的策略,有机羧酸衍生物是酰胺合成的理想原料.在这里,我们报告了n的合成-三氟甲基酰胺从羧酸卤化物和酯在温和条件下通过异硫氰酸酯在氟化银存在下在室温下.通过这种策略,异硫氰酸酯用 Agf 脱硫,然后将形成的衍生物酰化以提供n-三氟甲基酰胺,包括以前无法获得的结构.该方法适用范围广,凭借两个反应伙伴的多样性和可用性,为快速反应生成n-三氟甲基酰胺提供了平台,并应在高级中间体的改性中找到应用.
DOI:10.1016/j.Chempr.2021.07.005

专利信息

专利号:WO-2021014395-A1
优先权日:2019-07-24
标题:Process for the synthesis of deuterated capsaicin, capsaicinoids and synthetic capsaicin analogs
发明人：ORUGANTI SRINIVAS; AMRUTAPU SRAVANTH KUMAR; SAMPATH MAGESH; SEN SAIKAT
权利人:DR REDDY’S INST OF LIFE SCIENCES
摘要:The present application provides novel processes for the synthesis of deuterated intermediates of capsaicinoids, particularly II, III, IV and V of capsaicinoids, relating to pharmaceutical applications. The invention also provides novel intermediates of compounds of formula IX, XIV, XV, XVI, XVII, XVIII, XX and XXI utilized in the process of making deuterated capsaicin II, III, IV and V.

专利号:US-11873305-B2
优先权日:2020-06-30
标题 :Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds
发明人：ZHANG HAIMING; XU JIE; WUITSCHIK GEORG; ANGELAUD REMY; HEROLD SEBASTIAN; STUTZ ALFRED; BRUETSCH TOBIAS; BURKHARD JOHANNES
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:Provided herein are processes for the preparation of indolyl intermediates using Wenker Synthesis for the total synthesis of SERD compounds useful in the treatment of cancer.

专利号:WO-2024181781-A1
优先权日:2023-02-27
标 题:Substrate for synthesis of biological polymers having anti-aggregation function and biological polymer synthesis method using same
发明人：JANG MYOUNG HOON; CHOI JAE SUN
权利人:SP2 TX INC
摘要:The present invention relates to a substrate for the synthesis of biological polymers having an anti-aggregation function, and a biological polymer synthesis method using the substrate. The substrate according to an aspect may have anti-aggregation functionality to enable high-yield and high-purity processes in the synthesis of biological polymers.

专利号:US-2008032964-A1
优先权日:2006-04-10
标题:Process for the synthesis of azetidinone
发明人：KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
权利人:KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
摘要:Provided are intermediates useful for the synthesis of hydroxyl-alkyl substituted azetidinones, processes of their preparation, and processes for the synthesis of certain hydroxyl-alkyl substituted azetidinones. Also provided are processes for the synthesis of 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone, or ezetimibe.

专利号:WO-9312076-A1
优先权日:1991-12-13
标题:Reagents for automated synthesis of peptide analogs
发明人：WEBB THOMAS ROY
权利人:CORVAS INT INC
摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

专利号:US-2013267680-A1
优先权日:2010-09-15
标题:Total chemical synthesis of ubiquitin, ubiquitin mutants and derivatives thereof
发明人：OVAA HUIB; EL OUALID FARID; MERKX REMCO NICOLAAS SEBASTIAAN MICHEL
权利人:OVAA HUIB; EL OUALID FARID; MERKX REMCO NICOLAAS SEBASTIAAN MICHEL; STICHTING HET NL KANKERINST
摘要:The present invention relates to the field of total chemical synthesis of ubiquitin and related peptides. More in particular, a method is provided of solid phase synthesis of ubiquitin, ubiquitin mutants and derivatives thereof. It was the object of the present invention to provide an approach for the total chemical synthesis of ubuiqitin, which allows for the chemical synthesis of virtually any Ub mutant and giving high overall efficiency and purity. The present inventors have surprisingly found that this object can be realized with a method relying on incorporation of special amino acid building blocks. This approach was found to allow for exceptionally high yields of up to 14% and to provide an synthetic entry into virtually any ubiquitin derivative.