CAS: 52479-85-3; (2,3,4-Trihydroxyphenyl)(3,4,5-Trihydroxyphenyl)Methanone

上下游产品

CAS号149-91-7 没食子酸; 3,4,5-三羟基苯甲酸 | CAS号87-66-1 1,2,3-苯三酚 | CAS号610-02-6 2,3,4-三羟基苯甲酸 水合物

📜2,3,4-三羟基苯甲酸,邻苯三酚置于zinc(II) Chloride,三氯氧磷体系中,化学反应 2.5H,以90%的收率获得产物依昔苯酮
参考文献:聚羟基二苯甲酮作为 α-葡萄糖苷酶抑制剂的评价
标题:聚羟基二苯甲酮作为 α-葡萄糖苷酶抑制剂的评价
摘要:本实验旨在利用friedel-Crafts反应合成18种多羟基二苯甲酮,以对硝基苯基-β-D-吡喃半乳糖苷(pnpg)为底物,测定对α-葡萄糖苷酶的抑制活性.在这里,阿卡波糖 (Ic50 = 1674.75 µmol L-1) 用作参考抑制剂.结果表明,大多数目标化合物对α-葡萄糖苷酶具有显着的抑制活性.在所有这些化合物中,2,4,4',6-Butahydroxydiphenylketone (11) 被发现是最有效的 α-葡萄糖苷酶抑制剂,Ic50 值为 10.62 µmol L-1.此外,我们通过动力学分析发现这些化合物是竞争性抑制剂.结果表明,此类化合物可用于开发新的糖尿病治疗候选药物.
DOI:10.1002/ardp.201000147

专利信息

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-11766432-B2
优先权日:2018-07-27
标题 :Cleavable conjugates of catechol compounds and water-soluble polymers and methods of treatment using the same
发明人：BENTLEY MICHAEL; FANG ZHIHAO; WEIMER REBECCA; VIEGAS TACEY; MOREADITH RANDALL
权利人:SERINA THERAPEUTICS INC
摘要:Described are conjugates comprising a water-soluble polymer linked to a compound comprising a catechol moiety via a cleavable linkage, wherein the cleavable linkage is formed between the water-soluble polymer and a first phenolic hydroxyl group of the catechol moiety and a second phenolic hydroxyl group of the catechol moiety is linked to a blocking group wherein the rate of hydrolytic release of the compound comprising the catechol moiety is controlled, at least in part, through structure or design of the blocking group on the second phenolic hydroxyl group of the catechol moiety. Therefore, the rate of hydrolytic release of the compound comprising the catechol moiety can be tuned through structural design of the group on the second phenolic hydroxyl group of the catechol moiety. Compounds used in the synthesis of the described conjugates and methods of using the described conjugate and other compounds in the treatment of dopamine-responsive disorders are also described.

专利号:EP-0706089-A3
优先权日:1994-10-05
标 题 :Process for the synthesis of a quinonediazide ester and positive working photoresist containing it