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N-α-邻苯二酰-L-谷氨酰胺置于4-二甲氨基吡啶,N,N'-羰基二咪唑体系中,用 四氢呋喃 作为反应溶剂,化学反应 16.0H,以91%的收率获得产物沙利度胺
参考文献:A Concise Two-Step Synthesis Of Thalidomide
标题:A Concise Two-Step Synthesis Of Thalidomide
摘要:A Two-Step Synthesis Of Thalidomide Is Presented. The Sequence Requires No Purifications. Treatment Of L-Glutamine With N-Carbethoxyphthalimide Produces N-Phthaloyl-L-Glutamine. Cyclization Of N-Phthaloyl-L-Glutamine To Afford Thalidomide Is Accomplished By Treatment With Cdi In The Presence Of A Catalytic Amount Of Dmap.
DOI:10.1021/op980201B