CAS: 4793-24-2; 2-Chloro-4-Fluoro-5-Sulfamoylbenzoic Acid

该化合物是一种多用途的苯并酸衍生物,含有氯,氟和硫磺酰的功能组,其独特的替代模式增强了反应性,使其成为制药和农用化学合成中有价值的中间体.硫代氨基化合物有进一步衍生的潜力,而电子提炼氯和氟代基化合物则影响其电子特性,有助于生物活性化合物的设计.该化合物具有高度纯度和稳定性,适合医药化学和材料科学的精确应用.其结构特征使得有选择地进行修改,支持开发用于研究和工业用途的定向分子.

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CAS号2252-51-9 2-氯-4-氟苯甲酸 | CAS号4818-59-1 2-Chloro-4-furf...

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    📜2-氯-4-氟苯甲酸置于氯磺酸,Ammonium Hydroxide体系中,用 1,4-二氧六环,水 作为反应溶剂,化学反应生成 2-氯-4-氟-5-氨磺酰基苯甲酸
    参考文献:Novel 4,4-Disubstituted Piperidine-Based C-c Chemokine Receptor-5 Inhibitors With High Potency Against Human Immunodeficiency Virus-1 And An Improved Human Ether-A-Go-Go Related Gene (Herg) Profile
    标题:Novel 4,4-Disubstituted Piperidine-Based C-c Chemokine Receptor-5 Inhibitors With High Potency Against Human Immunodeficiency Virus-1 And An Improved Human Ether-A-Go-Go Related Gene (Herg) Profile
    摘要:We Recently Described (J. Med. Chem. 2008,51,6538-6546) A Novel Class Of Ccr5 Antagonists With Strong Anti-Hiv Potency. Herein,We Detail Sar Converting Leads 1 And 2 To Druglike Molecules. The Pivotal Structural Motif Enabling This Transition Was The Secondary Sulfonamide Substituent. Further Fine-Tuning Of The Substituent Pattern In The Sulfonamide Paved The Way To Enhancing Potency And Bioavailability And Minimizing Herg Inhibition,Resulting In Discovery Of Clinical Compound 122 (Gsk163929).
    DOI:10.1021/jm200279V

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    参考文献:10.1007/s00044-021-02840-4
    摘要:Salvador PJ, Jacobs HB, Alnouri L, Fee A, Utley LM, Mabry M, Krajeck H, Dicksion C, Awad AM. Synthesis and in silico evaluation of novel uridyl sulfamoylbenzoate derivatives as potential anticancer agents targeting M1 subunit of human ribonucleotide reductase (hRRM1). Medicinal Chemistry Research. 2022 Jan 28;31(7):1109–19. doi: 10.1007/s00044-021-02840-4.
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