CAS: 4331-29-7; 1H-Benzo[d]Imidazol-7-Amine

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📜2,6-二硝基苯胺置于palladium On Activated Charcoal,Ru-Carbon 盐酸,氢气,一水合肼体系中,用 甲醇,乙醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 54.0H,反应生成 4-氨基苯并咪唑
参考文献:嘧啶和嘌呤n-[2-(2-膦酰基甲氧基)乙基]核苷酸类似物系列中的结构-抗病毒活性关系.1.在碱的碳原子上取代的衍生物.
标题:嘧啶和嘌呤n-[2-(2-膦酰基甲氧基)乙基]核苷酸类似物系列中的结构-抗病毒活性关系.1.在碱的碳原子上取代的衍生物.
摘要:通过对烷基进行烷基化制备一系列嘌呤和嘧啶n-[2-(膦甲氧基)乙基]衍生物的二烷基酯,其在嘌呤碱的位置2,6或8或在嘧啶碱的位置2,4或5.在氢化钠,碳酸铯或1,8-二氮杂双环[5,4,0]十一碳-7-烯(dbu)存在下的二甲基甲酰胺中,与2-氯乙氧基甲基膦酸酯二酯形成合适的杂环碱.通过在适当修饰的中间体上对碱基进行转化,获得额外的衍生物,该中间体在碱基部分具有反应性功能.通过叠氮化钠处理将二酯转化为相应的单酯,同时通过依次用溴代三甲基硅烷处理和水解从二酯中获得游离酸.嘧啶系列中没有pme衍生物,它们的6-氮杂或3-氮杂类似物,除5-溴胞嘧啶衍生物外,对测试的dna病毒或逆转录病毒均表现出任何活性.cl,F或oh基团取代了pmea中2位的腺嘌呤环,从而降低了其对所有测试的dna病毒的活性.在0.07-2 Microg / Ml的浓度范围(ec50)中,Pmedap对hsv-1,Hsv-2
DOI:10.1021/jm9811256

专利信息

专利号:US-9388131-B2
优先权日:2011-04-27
标题:Automated synthesis of small molecules using chiral, non-racemic boronates
发明人：BURKE MARTIN D; LI JUNQI; GILLIS ERIC P
权利人:UNIV ILLINOIS
摘要:Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification.

专利号:US-10844081-B2
优先权日:2015-08-07
标题 :Protected organoboronic acids with tunable reactivity, and methods of use thereof
发明人：BURKE MARTIN D; SCHMIDT MICHAEL; MOREHOUSE GREG; PIPAL ROBERT W
权利人:UNIV ILLINOIS
摘要:Disclosed are a range of protected organoboronic acid reagents useful in the modular assembly of complex organic compounds. The reactivities of the protected organoboronic acid reagents may be varied predictably by changes to the number and identities of their substituents. Also disclosed are methods of using the protected organoboronic acid reagents in the synthesis of organic compounds.

专利号:US-12018251-B2
优先权日:2017-10-13
标 题:Method for synthesis of polynucleotides using a diverse library of oligonucleotides
发明人：VLADAR HAROLD PAUL; FERNANDES REDONDO RODRIGO APARECIDO
权利人:RIBBON BIOLABS GMBH
摘要:A method for synthesizing a target double stranded (ds) polynucleotide byproviding an oligonucleotide library within an array device that has a diversity of oligonucleotide library members, each of which has a different nucleotide sequence and is contained in a separate library containment in an aqueous solution. The library includes single stranded oligonucleotides and double stranded oligonucleotides with at least one overhang and covers at least 10,000 pairs of matching oligonucleotides. In a first step, at least a first pair of matching oligonucleotides are transferred transferred from the library into a first reaction containment using a liquid handler and the matching oligonucleotides are assembled, thereby obtaining a first reaction product comprising at least one overhang. Further reaction products are then likewise obtained and are assembled in a predetermined workflow using an algorithm, thereby producing said target ds polynucleotide with an overhang, optionally followed by a finalization step to prepare blunt ends.

专利号:US-12195777-B2
优先权日:2018-02-02
标 题 :Polynucleotide synthesis method, kit and system
发明人：HERON ANDREW JOHN
权利人:OXFORD NANEPORE TECH PLC; OXFORD NANOPORE TECH PLC
摘要:The invention relates to new in vitro methods for synthesising a polymer, particularly a polynucleotide molecule, having a pre-defined sequence of units such as nucleotides. For synthesising a polynucleotide molecule the methods involve a process of extending a polynucleotide synthesis molecule with a transfer nucleotide. The methods additionally involve repeating the extension process multiple times to iteratively extend the polynucleotide molecule with multiple transfer nucleotides to generate a new polynucleotide molecule having a pre-defined nucleotide sequence. The invention also relates to in vitro methods of joining multiple synthetic polynucleotides following synthesis to form larger synthetic polynucleotides, as well as devices and systems for performing the extension, synthesis and assembly methods of the invention.

专利号:US-2022396818-A1
优先权日:2019-09-10
标 题:Polynucleotide synthesis method, kit and system
发明人：MILTON JOHN; NAYYAR SOBIA; RIEDL JAN; OGAKI RYOSUKE; WILKINSON MARC GEORGE
权利人:OXFORD NANOPORE TECH PLC
摘要:The invention relates to new methods for synthesising polynucleotide molecules according to a predefined nucleotide sequence. The invention also relates to methods for the assembly of synthetic polynucleotides following synthesis, as well as systems and kits for performing the synthesis and/or assembly methods.

专利号:US-12037636-B2
优先权日:2018-07-19
标题 :Polynucleotide synthesis method, kit and system
发明人：MILTON JOHN; NAYYAR SOBIA; RIEDL JAN; OGAKI RYOSUKE
权利人:OXFORD NANOPORE TECH PLC
摘要:The invention relates to new methods for synthesising polynucleotide molecules according to a predefined nucleotide sequence. The invention also relates to methods for the assembly of synthetic polynucleotides following synthesis, as well as systems and kits for performing the synthesis and/or assembly methods.