CAS: 396091-73-9; Pasireotide

上下游产品

2-CH2-NH-B°C)-Phg-D-Trp(B°C)-Lys(B°C)-Tyr(Bzl)-Phe]cyclo[Pro(4-°CO-NH-CH2-CH2-NH-B°C)-Phg-D-Trp(B°C)-Lys(B°C)-Tyr(Bzl)-Phe] bis(trichloromethyl) carbonate N-B°C-1,2-diaminoethane

Cyclo[pro(4-oco-Nh-Ch2-Ch2-Nh-Boc)-Phg-D-Trp(Boc)-Lys(Boc)-Tyr(Bzl)-Phe]置于三异丙基硅烷,三氟乙酸体系中,用 水 用作溶剂,化学反应 1.0H,反应生成帕瑞肽
参考文献: Novel Process For The Preparation Of Pasireotide[fr] Nouveau Procédé De Préparation De Pasiréotide
标题: Novel Process For The Preparation Of Pasireotide[fr] Nouveau Procédé De Préparation De Pasiréotide
摘要:本发明涉及一种用于制备化学式11的帕西瑞肽的新型工艺.该发明还涉及一种化学式8的新型中间化合物及其制备工艺,该中间化合物用于制备化合物11.

专利信息

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-2020354404-A1
优先权日:2019-05-09
标 题 :Peptidomimetic agents, synthesis and uses thereof
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.

专利号:US-2015158809-A9
优先权日:2013-02-26
标 题 :Method of making 1-(acyloxy)-alkyl carbamate compounds
发明人：WANG HUAN; LIU PENG; DAI QUNYING; YIN HAO; RAILLARD STEPHEN P
权利人:XENOPORT INC
摘要:Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.

专利号:US-10919882-B2
优先权日:2019-05-09
标题:Compounds for use in synthesis of peptidomimetics

专利号:CA-2551859-C
优先权日:2003-12-30
标题 :Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof

专利号:JP-2025506322-A
优先权日:2022-02-04
标题 :Methods for the large scale synthesis of radionuclide complexes.