CAS: 3801-06-7; (6S,8S,9R,10S,11S,13S,14S,17R)-17-Acetyl-9-Fluoro-11-Hydroxy-6,10,13-Trimethyl-3-Oxo-6,7,8,9,10,11,12,13,14,15,16,17-Dodecahydro-3H-Cyclopenta[a]Phenanthren-17-Yl Acetate

上下游产品

[(6S,8S,10R,13S,14S,17R)-17-乙酰基-6,10,13-三甲基-3-氧代-7,8,12,14,15,16-六氢-6H-环戊二烯并[a]菲-17-基]乙酸酯 6-Methyl-3,20-Dioxo-1,4,9(11)-Pregnatrien-17-Acetate 130145-14-1
(9Beta,11Beta)-环氧氟米龙乙酸酯 17α-Acetoxy-6α-Methyl-9β,11β-Oxidopregna-1,4-Dien-3,20-Dione 83873-17-0

(9Beta,11Beta)-环氧氟米龙乙酸酯置于氢氟酸体系中,用 水 作为反应溶剂,化学反应 4.0H,以84.7%的收率获得产物氟米龙醋酸酯
参考文献:氟米龙及氟米龙醋酸酯与制备方法
标题:氟米龙及氟米龙醋酸酯与制备方法
摘要:本发明公开了一种氟米龙及氟米龙醋酸酯与制备方法.该制备方法以式ⅱ所示化合物为原料,依次经过脱氯反应,酯化反应,次甲基化反应,氢化反应,发酵脱氢反应,环氧反应,开环反应,制得氟米龙的衍生物,氟米龙的衍生物再经过水解反应,制得氟米龙,该制备方法合成路线短,收率高,原料成本低,原料易得,纯化方便简单,产品纯度高,工艺可操作性强,适合于工业化生产,具有很高的工业化价值.

专利信息

专利号:US-8734846-B2
优先权日:2008-06-16
标 题 :Methods for the preparation of targeting agent functionalized diblock copolymers for use in fabrication of therapeutic targeted nanoparticles
发明人：ALI MIR M; HRKACH JEFF; ZALE STEPHEN E; ALVAREZ DE CIENFUEGOS LUIS
权利人:BIND BIOSCIENCES INC
摘要:This application provides nanoparticles and methods of making nanoparticles using pre-functionalized poly(ethylene glycol)(also referred to as PEG) as a macroinitiator for the synthesis of diblock copolymers. Ring opening polymerization yields the desired poly(ester)-poly (ethylene glycol)-targeting agent polymer that is used to impart targeting capability to therapeutic nanoparticles. This “polymerization fromâ€? approach typically employs precursors of the targeting agent wherein the reactivity of functional groups of the targeting agent is masked using protecting groups. Also described is a “coupling toâ€? that utilized the poly(ethylene glycol)-targeting agent conjugate where the targeting agent remains in its native un-protected form. This method uses “orthogonalâ€? chemistry that exhibit no cross reactivity towards functional groups typically found within targeting agents of interest.

专利号:US-9051302-B2
优先权日:2008-01-15
标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents
发明人：WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN
权利人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN; UNIV STRASBOURG
摘要:Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.

专利号:US-2013035307-A1
优先权日:2010-01-26
标 题:Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers
发明人：PRESTWICH GLENN D; KENNEDY THOMAS P
权利人:UNIV UTAH RES FOUND; PRESTWICH GLENN D; KENNEDY THOMAS P
摘要:Described herein are methods for the treatment and prevention of tumor metastasis using alkylated and fluoroalkylated semi-synthetic glycosaminoglycan ethers (“SAGEsâ€?). The synthesis of sulfated alkylated and fluoroalkylated SAGEs is also described.

专利号:WO-2010122096-A1
优先权日:2009-04-23
标题:Process for obtaining fluorometholone and intermediates therefor
发明人：LORENTE BONDE-LARSEN ANTONIO; IGLESIAS RETUERTO JESUS MIGUEL; HERRAIZ SIERRA IGNACIO; BERMEJO GONZALEZ FRANCISCO; MARCOS ESCRIBANO JOSE ANDRES; GUTIERREZ FUENTES LUIS GERARDO
权利人:CRYSTAL PHARMA S L U; LORENTE BONDE-LARSEN ANTONIO; IGLESIAS RETUERTO JESUS MIGUEL; HERRAIZ SIERRA IGNACIO; BERMEJO GONZALEZ FRANCISCO; MARCOS ESCRIBANO JOSE ANDRES; GUTIERREZ FUENTES LUIS GERARDO
摘要:The present invention relates to a process for obtaining compounds of formula (I) and (V), wherein R 1 is C 1 -C 6 alkyl; and R 2 is OR 3 , OC(=O)R 4 or O-(HPG), wherein R 3 is H, C 1 -C 6 alkyl or C 6 -C 14 aryl; R 4 is H or C 1 -C 6 alkyl; and HPG is a hydro xyl protecting group, intermediates useful in the synthesis of some steroids, for example, fluorometholone and derivatives thereof. The invention also relates to other intermediates useful in synthesis.

专利号:WO-2023096715-A9
优先权日:2021-10-22
标 题:Immunomodulatory glycosphingolipids and methods of use thereof
发明人：KASPER DENNIS; OH SUNGWHAN
权利人:HARVARD COLLEGE
摘要:Provided herein are a subset of alpha-galactosylceramide (alpha-GC) compounds having improved immunomodulatory activity, particularly with respect to NKT cell number and activity. Also provided herein are methods of use of such compounds, including in the modulation of NKT cells and/or activity in vivo. Further provided are combinatorial synthesis methods for generating alpha-GC compounds of specifically defined structure and thereby generating pure preparations thereof.

专利号:US-9982006-B2
优先权日:2014-08-21
标题:2′-chloro aminopyrimidinone and pyrimidine dione nucleosides
发明人：CLARKE MICHAEL O'NEIL HANRAHAN; MACKMAN RICHARD L; SIEGEL DUSTIN
权利人:GILEAD SCIENCES INC
摘要:Provided herein are formulations, methods and substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds.