专利号:US-6673960-B1 优先权日:1998-06-18 标 题 :Work-up of distillation residues from the synthesis of toluene diisocyanate 发明人:SCHWARZ HANS VOLKMAR; MAURER MARKUS; SANDER MICHAEL; STROEFER ECKHARD; LEUTHOLD RENE; HANTEL BURGHARD; RICHTER SIEGFRIED; THERRE JOERG 权利人:BASF AG 摘要:A process for working up distillation residues from the synthesis of tolylene diisocyanate by reaction of the distillation residues with water comprises reacting the TDI distillation residues with water in a continuous or semicontinuous process in a backmixed reactor in the presence of hydrolysate.
专利号:US-2024124910-A1 优先权日:2021-02-02 标题:Ribosome-mediated polymerization of novel chemistries 发明人:JEWETT MICHAEL CHRISTOPHER; LEE JOONGOO; ANSLYN ERIC V; CORONADO JAIME; LIM JONGDOO 权利人:UNIV NORTHWESTERN; UNIV TEXAS 摘要:Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.
专利号:US-6953850-B1 优先权日:1999-01-18 标题:Protecting groups for carbohydrate synthesis 发明人:DEKANY GYULA; PAPAGEROGIOU JOHN; BORNAGHI LAURENT FRANCOIS 权利人:ALCHEMIA PTY LTD 摘要:The invention provides collections of orthogonally-protected monosaccharides as universal building blocks for the synthesis of glycoconjugates of non-carbohydrate molecules, neo-glycoconjugates and oligosaccharides. This orthogonal protection strategy allows for the specific deprotection of any substituent ono the saccharide ring, and greatly facilitates targeted or library-focused carbohydrate-related syntheses. In particular, the invention provides a universal monosaccharide building block of General Formula (I) or General Formula (II) in which A is a leaving group; X is hydrogen, O, N or N 3 ; X 1 is hydrogen, —CH 2 O—, —CH 2 NH—, —CH 3 , —CH 2 N 3 or —COO—; and B, C, D and E are protecting groups that can be cleaved orthogonally, and in which B, C, D and E are absent when X is hydrogen or N 3 , and E is absent when X 1 is hydrogen, CH 3 or N 3 .
专利号:US-11970694-B2 优先权日:2009-10-22 标题 :Rapid display method in translational synthesis of peptide 发明人:KASHIWAGI KENJI; REID PATRICK 权利人:PEPTIDREAM INC 摘要:Provided are linkers suitable for preparing a conjugate of a nucleic acid and a peptide as a translation product thereof in a reconstituted cell-free translation system in genotype-phenotype mapping (display methods), said linkers comprising a single-stranded structure region having a side chain base pairing with the base at the 3′-end of an mRNA at one end and a peptidyl acceptor region containing an amino acid attached to an oligo RNA consisting of a nucleotide sequence of ACCA via an ester bond at the other end, characterized in that the ester bond is formed by using an artificial RNA catalyst. Also provided are display methods using [mRNA]-[linker]-[peptide] conjugates assembled via such linkers.
专利号:US-5820764-A 优先权日:1993-12-31 标题:Treatment/removal of byproduct aqueous effluents comprising hydroxynitro-aromatic compounds 发明人:JOULAK FAOUZI; LE BRIS LOUIS; MARION PHILIPPE 权利人:RHONE POULENC CHIMIE 摘要:Objectionable byproduct aqueous effluents containing contaminating amounts of hydroxynitroaromatic compounds, in particular those aqueous effluents produced during the synthesis of nitroaromatic compounds, e.g., dinitrotoluenes, via reaction of an aromatic compound with nitric acid in the presence of sulfuric acid, are efficiently, facilely and economically treated/removed by (a) intimately contacting a mixture of at least one nitroaromatic compound and at least one hydroxynitroaromatic compound with an aqueous wash medium containing a neutralizing agent, (b) separating the resulting admixture into an organic phase and an aqueous phase, (c) recycling a fraction of the separated aqueous phase to the aqueous wash medium to thus constitute a portion thereof, and (d) periodically draining a fraction of the wash medium, whether to destruction thereof or to waste.
专利号:US-4687784-A 优先权日:1985-02-04 标题:CO hydrogenation with molybdenum of wide-pore carbon catalysts 发明人:FOLEY HENRY C; O'TOOLE MICHAEL P 权利人:AMERICAN CYANAMID CO 摘要:New catalysts comprising molybdenum on supports of defined wide-pore carbons are useful as catalyst for reaction of CO with H 2 for synthesis of hydrocarbons. Catalysts may be made by depositing Mo(CO) 6 on the carbon support particles by vapor deposition or solution impregnation. The catalyst may also comprise a second metal, such as rhodium or palladium.
摘要:National Technical Information Service., AD-A080-146 摘要:DOUSE JM F; J CHROMATOGR 208 (1): 83 (1981) 摘要:HARTLEY WR ET AL; TRACE SUBST ENVIRON HEALTH 15: 298 (1981) 摘要:Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981., p. 1 摘要:Chem Indus Inst of Tox Report: A Thirty Day Toxicology Study in Fischer-344 Docket # 22397 p.IV (1977)