专利号:US-6486355-B1 优先权日:2000-02-23 标 题:Application of chiral critical clusters to assymetric synthesis 发明人:FERRIERI RICHARD A 权利人:BROOKHAVEN SCIENCE ASS LLC 摘要:Disclosed is a composition, a method of making and a method of using critical clusters for asymmetric synthesis using substantially optically-pure chiral solvent molecules in a supercritical fluid. The solvent molecules are capable of forming a multipoint hydrogen bonded solvate as they encage at least one solute molecule. The encaged solute molecule is capable of reacting to form an optically active chiral center. In another aspect, there is disclosed a method of directing the position of bonding between a solute molecule and a ligand involving encaging the solute molecule and the ligand with polar solvent molecules in a supercritical fluid under conditions of temperature and pressure sufficient to change electric charge distribution in the solute molecule. In yet another aspect, disclosed is a method of making pharmaceutical compounds involving encaging a solute molecule, which is capable of forming a chiral center, and a ligand with polar solvent molecules in a supercritical fluid under conditions of temperature and pressure sufficient to change electric charge distribution of the solute molecule. The solute molecule and ligand are then reacted whereby the ligand bonds to the solute molecule forming a chiral center. Also disclosed is a method for racemic resolution using critical clusters involving encaging racemic mixtures of solute molecules with substantially optically-pure chiral solvent molecules in a supercritical fluid under conditions of temperature and pressure sufficient to form critical clusters. The solvent molecules are capable of multipoint hydrogen bonding with the solute molecules. The encaged solute molecules are then nonenzymatically reacted to enhance the optical purity of the solute molecules.
专利号:SU-1392094-A1 优先权日:1986-06-02 标 题:Recombination plasmodium dna sec10 encoding synthesis of fragment of dna-polymerase i e coli and method of its construction
专利号:US-7674934-B2 优先权日:2004-08-05 标题:Stabilizers for use in NVP synthesis 发明人:HOEFER FRANK; BRAND ALEXANDRA; BOETTCHER ARND; BAUMANN KATRIN; VOGELSANG REGINA 权利人:BASF AG 摘要:A process for preparing N-alkenyl compounds by reacting the corresponding NH compounds with alkynes in the liquid phase in the presence of a catalyst, wherein the reaction is carried out in the presence of at least one stabilizer, and the use of stabilizers for increasing the selectivity in a process for preparing N-alkenyl compounds by reacting the corresponding NH compounds with alkynes in the liquid phase in the presence of a catalyst.
参考标题:Traceless Solid-Phase Synthesis Of Cyclopenta[C]Quinolines And Cyclopenta[C]Chromenes Via Hetero [6+3] Cycloadditions Of Fulvene. A Facile Approach To The 11-Heterosteroids Framework 作者:Bor-Cherng Hong,Zhong-Yi Chen,Wei-Hung Chen,Hsu-I Sun,Gene-Hsiang Lee |发布日期:2005.2 摘要:The Hetero [6+3] Cycloaddition Of Fulvenes To Benzoquinones And Iodoanilines Provides An Efficient Route To The Synthesis Of Cyclopenta[c]-4H-Chromen-8-Ol, Benzo[d]Cyclopenta[e]-3H-3-Azin-8-Ol And Other 11Hetero Steroids. The Structure Of The Cyclopenta[c]Chromene Skeleton Was Confirmed By The X-Ray Structure Analysis Of The P-Bromobenzoate Of 39. A Small Library Consisting Of 110 Examples Was Prepared
合成参考文献
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