CAS: 188781-08-0; Ethyl 2-Chloro-4-Methylpyrimidine-5-Carboxylate

相似化合物

188781-10-4 108381-23-3 1215922-76-1

上下游产品

ethyl 2-hydroxy-4-methylpyrimidine-5-carboxylate ethyl 2-acetyl-3-ureido-2-propenoate ethyl acetoacetate 6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester2-chloro-4-methyl-pyrimidine-5-carboxylic acid 2-hydrazino-4-methyl-pyrimidine-5-carboxylic acid ethyl ester 2-benzylamino-4-methylpyrimidine-5-carboxylic acid ethyl ester 2-amino-4-methylpyrimidine-5-carboxylic acid ethyl ester

4-甲基-2-羟基嘧啶-5-羧酸乙酯置于n,N-二异丙基乙胺,三氯氧磷体系中,化学反应 2.0H,以45%的收率获得4-甲基-2-氯嘧啶-5-羧酸乙酯
参考文献: Pyrimidine Amide Compounds[fr] Composés Pyrimidine Amide
标题: Pyrimidine Amide Compounds[fr] Composés Pyrimidine Amide
摘要:本文提供的化合物为式(I)的化合物及其药学上可接受的盐,其中取代基如规范中所披露的那样.这些化合物及含有它们的药物组合物对于治疗炎症性疾病和紊乱,例如哮喘和慢性阻塞性肺病(copd)等,具有实用性.

专利信息

专利号:US-10906888-B2
优先权日:2016-07-14
标 题:Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; STROHBACH JOSEPH WALTER; HEPWORTH DAVID; LOVERING FRANK ELDRIDGE; CHOI CHULHO; ALLAIS CHRISTOPHE PHILIPPE; WRIGHT STEPHEN WAYNE
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.