合成目标产物 Trimethylsulfoxonium Iodide 主要起始原料 Dimethyl Sulfoxide And Iodomethane
(文献来源)合成步骤主要原料 Dimethyl Sulfoxide 和 Iodomethane
Dimethyloxosulfonium Methylide 反应生成三甲基碘化亚砜 参考文献:9-(2-Hydroxy-3-Amino-Propyl)-9,10-Dihydro-9,10-Ethano-Anthracenes And 标题:9-(2-Hydroxy-3-Amino-Propyl)-9,10-Dihydro-9,10-Ethano-Anthracenes And 摘要:含有公式 ##str1## 核的9-(2-A-3-R-丙基)-9,10-二氢-9,10-乙烷蒽烯,其中r表示二级或三级氨基,A表示自由,醚化或酰化的羟基,它们的药学上可接受的盐可用作精神药物,特别是作为抗抑郁剂.
专利号:US-5476915-A 优先权日:1994-06-29 标题:Method for controlled synthesis of polymers 发明人:SHEA KENNETH J; WALKER JAMES R; ZHU HIUDE 权利人:UNIV CALIFORNIA 摘要:Living polymer synthesis methods for the synthesis of oligomeric and high molecular weight polymers with low polydispersity are disclosed. The disclosed methods are based on the discovery that the reaction of a ylid with an organoborane at a high ylid:borane ratio and high temperature provides for the synthesis of high molecular weight polymers with low polydispersity.
专利号:WO-2013018053-A1 优先权日:2011-08-02 标题 :Process for the preparation of epoxides as intermediates for the synthesis of nebivolol 发明人:CIPOLLONE AMALIA; D ANDREA PIERO; FATTORI DANIELA 权利人:MENARINI INT OPERATIONS LU SA; CIPOLLONE AMALIA; D ANDREA PIERO; FATTORI DANIELA 摘要:The present invention relates to a novel process of synthesis of epoxides, 6-fluoro-2- (oxiran-2-yl) chroman (Figure 1), intermediates for the synthesis of nebivolol, depicted in Scheme (1), enabling to obtain the above- mentioned epoxides in a racemic or semichiral form.
专利号:EP-2644590-A1 优先权日:2012-03-30 标 题:Synthesis of 2-(3,4-difluorophenyl)cyclopropanamine derivatives and salts 权利人:LEK PHARMACEUTICALS 摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.
专利号:US-9884830-B2 优先权日:2004-05-21 标题 :Synthesis of tetracyclines and analogues thereof 发明人:MYERS ANDREW G; CHAREST MARK G; LERNER CHRISTIAN D; BRUBAKER JASON D; SIEGEL DIONICIO R 权利人:HARVARD COLLEGE 摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals.
专利号:US-8486921-B2 优先权日:2006-04-07 标 题:Synthesis of tetracyclines and analogues thereof 发明人:MYERS ANDREW G; BRUBAKER JASON D; SUN CUIXIANG; WANG QIU 权利人:MYERS ANDREW G; BRUBAKER JASON D; SUN CUIXIANG; WANG QIU; HARVARD COLLEGE 摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetra-cycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-pro liferative agents in the treatment of diseases of humans or other animals.
专利号:EP-2589587-A1 优先权日:2011-11-04 标题:Synthesis of nitrogen substituted cyclopropanes 发明人:RASPARINI MARCELLO; TADDEI MAURIZIO; CINI ELENA; MINELLI COSIMA; TURNER NICHOLAS; HUGENTOBLER KATHARINA GLORIA 权利人:CHEMO IBERICA SA 摘要:The invention is about a new synthetic pathway for the preparation of enantiomerically pure nitrogen substituted cyclopropanes, in particular the trans- cyclopropanamine ( 1 ), a key intermediate in the synthesis of Ticagrelor:n n The invention also relates to the processes for preparing said compounds or their salts and the use of said compounds as intermediates in preparing pharmaceutically active ingredients.
[参考文献]: S Taboada, Et Al. Optical Phonons, Crystal-Field Transitions, And Europium Luminescence-Excitation Processes In Eu2Bacoo5: Experiment And Theory. Phys Rev B Condens Matter. 1994 Oct 1;50(13):9157-9168.
合成参考文献
摘要:de Meijere, A.; Kozhushkov, S. I., Science of Synthesis, (2009) 48, 586. 摘要:Trofimova, A.; Sirvinskas, M.; Yudin, A. K., Science of Synthesis Knowledge Updates, (2021) 2, 75. 摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025). 摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025).