CAS: 152121-47-6; 4-(5-(4-Fluorophenyl)-2-(4-(Methylsulfinyl)Phenyl)-1H-Imidazol-4-yl)Pyridine

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CAS号152121-44-3 4-[4-(4-Fluorop... | CAS号586-95-8 4-吡啶甲醇 | CAS号403-43-0 对氟苯甲酰氯 | CAS号116332-54-8 N-甲基-N-甲氧基-4-氟苯甲酰胺 | CAS号117423-41-3 4-(叔丁基二甲基甲硅烷基氧基甲基)吡啶 | CAS号152122-41-3 2-(tert-butyldi...

📜4-[4-(4-氟苯基)-2-[4-(甲硫基)苯基]-1H-咪唑-5-基]吡啶置于dipotassium Peroxodisulfate,溶剂黄146体系中,化学反应 18.0H,以78%的收率获得4-(4-氟苯基)-2-(4-甲基亚磺酰基苯基)-5-(4-吡啶基)-1H-咪唑
参考文献:Regulation Of Stress-Induced Cytokine Production By Pyridinylimidazoles; Inhibition Of Csbp Kinase
标题:Regulation Of Stress-Induced Cytokine Production By Pyridinylimidazoles; Inhibition Of Csbp Kinase
摘要:Members Of Three Classes Of Pyridinylimidazoles Bind With Varying Affinities To Csbp (P38) Kinase Which Is A Member Of A Stress-Induced Signal Transduction Pathway. Based Upon Sar And Protein Homology Modeling,The Pharmacophore And Three Potential Modes Of Binding To The Enzyme Are Presented. For A Subset Of Pyridinylimidazoles,Binding Is Shown To Correlate With Inhibition Of Csbp Kinase Activity,Whereas No Significant Inhibition Of Pka,Pkc Alpha And Erk Kinase Activity Is Observed. Copyright (C) 1997 Elsevier Science Ltd.
Doi:10.1016/s0968-0896(96)00212-X

专利信息

专利号:US-2006246505-A1
优先权日:2003-09-02
标题:Modulation of the synthesis of insulin
发明人：WALTHER REINHARD
权利人:WALTHER REINHARD
摘要:The invention particularly relates to the use of substances, which modulate the activity of the proteins casein kinase II (CK II) and 14-3-3 epsilon and/or of the PcG protein EED or which influence the binding of the proteins casein kinase II (CK II) and 14-3-3 epsilon, of the PcG protein EED and/or of a fragment thereof with the protein pancreatic duodenal homeobox-1 (PDX-1) that plays a decisive roll in the glucose-induced biosynthesis of insulin, for influencing the synthesis of insulin or the provision of insulin.

专利号:EP-1546732-B1
优先权日:2002-09-03
标 题:Modulation of the synthesis of insulin
发明人：WALTHER REINHARD
权利人:UNIV ERNST MORITZ ARNDT
摘要:The invention particularly relates to the use of substances, which modulate the activity of the proteins casein kinase II (CK II) and 14-3-3 epsilon and/or of the PcG protein EED or which influence the binding of the proteins casein kinase II (CK II) and 14-3-3 epsilon, of the PcG protein EED and/or of a fragment thereof with the protein pancreatic duodenal homeobox-1 (PDX-1) that plays a decisive roll in the glucose-induced biosynthesis of insulin, for influencing the synthesis of insulin or the provision of insulin.

专利号:US-2024239805-A1
优先权日:2022-12-16
标 题:Aza-yang cyclization-buchner aromatic ring expansion: collective synthesis of cycloheptatriene-containing azetidine lactones
发明人：SINGH MANVENDRA PAL; BOSKOVIC ZARKO; GASKINS BRYCE
权利人:UNIV KANSAS
摘要:The present disclosure is directed to a compound of Formula I, Formula II, Formula III, Formula IV, or Formula Vor a pharmaceutically acceptable salt and/or solvate thereof.

专利号:US-2018351104-A1
优先权日:2012-11-02
标 题:3-substituted tellurophenes and related compounds
发明人：SEFEROS DWIGHT; JAHNKE ASHLEE
权利人:GOVERNING COUNCIL UNIV TORONTO
摘要:Monomeric 3-substituted tellurophene compounds, as well as their use in the synthesis of oligomeric and/or polymeric compounds consisting of two or more tellurophene-2,5-diyl groups which are covalently linked to each other are disclosed, as is the use of said oligomers and polymers in devices such as diodes and solar cells, electrodes and semiconductors.

专利号:WO-2023241717-A1
优先权日:2022-06-16
标题:Substance for promoting regeneration and repair of organs of mammals and use thereof
发明人：LI WEI; ZHOU QI; He zheng-quan; LU ZONGBAO; WANG SHUAI; WANG XIN; YUAN XUEWEI; WANG LIU
权利人:INST ZOOLOGY CAS; BEIJING INST FOR STEM CELL AND REGENERATIVE MEDICINE
摘要:Provided is use of a substance capable of up-regulating ISG gene expression in preparing a drug or reagent for promoting the regeneration and repair capacity of tissues or complex structures or organs of mammals. The substance for up-regulating ISG gene expression is selected from one or two or more of an MAPK inhibitor, a retinoic acid receptor-related orphan receptor inhibitor, a protein synthesis inhibitor, and an interferon (IFNγ, β, λ) or alarmin (S100A8/A9) protein. The regeneration and repair refer to promoting the regeneration of tissues or complex structures or organs after tissue or organ resection or damage.

专利号:US-9982006-B2
优先权日:2014-08-21
标题:2′-chloro aminopyrimidinone and pyrimidine dione nucleosides
发明人：CLARKE MICHAEL O'NEIL HANRAHAN; MACKMAN RICHARD L; SIEGEL DUSTIN
权利人:GILEAD SCIENCES INC
摘要:Provided herein are formulations, methods and substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds.