CAS: 112-23-2; Heptyl Formate

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CAS号111-70-6 正庚醇 | CAS号109-94-4 甲酸乙酯 | CAS号124-13-0 正辛醛 | CAS号64-18-6 甲酸 | CAS号111-71-7 正庚醛 | CAS号132336-04-0 2-heptoxyoxane | CAS号629-04-9 1-溴庚烷 | CAS号77287-34-4 甲亚胺酸 | CAS号111-70-6 正庚醇

📜正辛醛置于水,P-(Trifluoromethyl)Phenyl(Difluoro)-λ3-Bromane体系中,用 二氯甲烷 用作溶剂,化学反应 1.0H,以89%的收率获得甲酸庚酯
参考文献:Baeyer-Villiger 氧化的高价 λ3-溴烷策略:初级脂肪族和芳香族醛向甲酸盐的选择性转化,这在经典的 Baeyer-Villiger 氧化中是缺失的
标题:Baeyer-Villiger 氧化的高价 λ3-溴烷策略:初级脂肪族和芳香族醛向甲酸盐的选择性转化,这在经典的 Baeyer-Villiger 氧化中是缺失的
摘要:Baeyer-Villiger 氧化 (Bvo) 的概念独特的现代策略被开发出来.我们的新方法涉及将水初始水合为羰基化合物,然后将溴烷 (III) 上的高价芳基-λ(3)-溴烷与所得水合物进行配体交换,从而产生一种新型的活化 Criegee 中间体.由于超核,中间体经历 Bv 重排并通过芳基-λ(3)-溴基的轻松还原消除产生酯.这种新策略可以选择性地诱导直链脂肪族和芳香族伯醛的 Bv 重排,这在经典 Bvo 中是缺失的:例如,辛醛和苯甲醛提供了高选择性(> 95%)的重排甲酸酯我们的条件,而尝试的经典 Bvo 仅产生羧酸.这牢固地确立了 Bvo 新方法论的强大性质.
Doi:10.1021/ja104330G

专利信息

专利号:US-6512081-B1
优先权日:1997-07-21
标题:Synthesis of dithioester chain transfer agents and use of bis(thioacyl) disulfides or dithioesters as chain transfer agents
发明人：RIZZARDO ENZIO; THANG SAN HOA; MOAD GRAEME
权利人:E I DUPONT NEMOURS AND COMPANY; COMMW SCIENT IND RES ORG
摘要:This invention relates to the synthesis of dithiocarboxylic acid esters by reaction of bis(thioacyl) disulphides, thioacetals or vinylidane bis(thioether) with free-radicals (optionally in the presence of monomers). The invention also relates to processes for the synthesis of polymers utilising these dithioesters as polymerisation regulators (chain transfer agents) or to the use of bis(thioacyl) disulphides to generate dithioester chain transfer agents in situ.

专利号:US-10730904-B2
优先权日:2012-11-14
标 题:Method for liquid-phase synthesis of nucleic acid
发明人：NONOGAWA MITSURU; NAGATA TOSHIAKI; SAITO HIDEKI; YASUMA TSUNEO
权利人:TAKEDA PHARMACEUTICALS CO
摘要:In this method, an oligonucleotide represented by formula (II) [wherein Y 1 , Q, Base, r and r′ are each as defined in claim 1 ] is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R 1 , Y, Base, Z, Ar, R 2 , R 3 and n are each as defined in claim 1 ]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

专利号:WO-0125179-A1
优先权日:1999-10-01
标 题:Preparation of tetracyclic intermediates
发明人：CHEN QING PING; WOODS ROSS ALEXANDER; ELLIOTT ROBYN LOUISE
权利人:INST OF DRUG TECHNOLOGY AUSTRA; CHEN QING PING; WOODS ROSS ALEXANDER; ELLIOTT ROBYN LOUISE
摘要:The invention provides a process for preparing deoxytetracyclic compounds of formula (I) useful in the synthesis of anthracyclines by the rearrangement of thiono ester derivatives followed by reduction, as well as intermediates useful therefor. In said formula, R is H or optionally protected OH.

专利号:US-6225329-B1
优先权日:1998-03-12
标 题 :Modulators of protein tyrosine phosphatases (PTPases)
发明人：RICHTER LUTZ STEFAN; ANDERSEN HENRIK SUNE; VAGNER JOSEF; JEPPESEN CLAUS BEKKER; MOELLER NIELS PETER HUNDAHL; BRANNER SVEN; SU JING; BAKIR FARID; JUDGE LUKE MILBURN
权利人:NOVO NORDISK AS
摘要:The present invention provides novel compounds of Formula 1, compositions containing these compounds, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like, n wherein A, R 1 , R 2 , R 3 , R 4 , R 16 and R 17 are as defined in the specification. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:US-2005215772-A1
优先权日:2002-08-19
标 题:Furanone derivatives and methods of making same
发明人：KUMAR NARESH
权利人:KUMAR NARESH
摘要:Novel synthesis methods, to the products of such novel methods, and to uses of these products. In particular, the present invention provides methods for the reactions of furanones, in particular fimbrolides, with amines. The invention has particular application in the synthesis of halogenated 1,5-dihydro-pyrrol-2-one, 5-halomethylene substituted 1,5-dihydropyrrol-2-ones (lactam analogues of fimbriolides), 5-amino substituted furanones and 5-aminomethylene-2(5H)-furanones and their synthetic analogues. The invention also relates to novel compounds and uses thereof.

专利号:US-2005119332-A1
优先权日:1998-03-12
标 题 :Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases)
发明人：JEPPESEN LONE; ANDERSEN HENRIK S; OLSEN OLE H; JUDGE LUKE M; HOLSWORTH DANIEL D; BAKIR FARID; AXE FRANK U; GE YU
摘要:The present invention provides novel compounds of formula 1a, n nnovel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.