CAS: 1078-19-9; 6-Methoxy-3,4-Dihydronaphthalen-1(2H)-One

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6836-19-7 63215-31-6 16821-32-2

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3-甲氧基氯苄置于palladium On Activated Charcoal Palladium Diacetate,氢氧化钾,Polyphosphoric Ester,三正丁胺,氢气体系中,用 乙醇,氯仿 用作溶剂,化学反应 23.0H,反应生成6-甲氧基-1-萘满酮
参考文献:Synthesis Of Substituted 1-Tetralones
标题:Synthesis Of Substituted 1-Tetralones
摘要:
Doi:10.1080/00304949709355222

专利信息

专利号:US-5763681-A
优先权日:1989-09-06
标 题 :Synthesis of stable, water-soluble chemiluminescent 1,2-dioxetanes and intermediates therefor
发明人：EDWARDS BROOKS; JUO RHOU-RONG
权利人:TROPIX INC
摘要:A novel synthesis of compound having the formula: ##STR1## wherein T is a stabilizing spiro-linked polycycloalkylidene group, R 3 is a C 1 -C 20 alkyl, aralkyl or heteroatom containing group, Y is an aromatic fluorescent chromophore, and Z is a cleavable group which, when cleaved, induces decomposition of the dioxetane ring and emission of optically detectable light, is disclosed. A tertiary phosphorous acid alkyl ester of the formula: n n (R.sup.1 O).sub.3 P n n wherein R 1 is a lower alkyl group, is reacted with an aryl dialkyl acetal produced by reacting a corresponding aryl aldehyde with an alcohol of the formula: n n R.sup.3 OH n n wherein R 3 is as defined above, to produce a 1-alkoxy-1-aryl-methane phosphonate ester of the formula: ##STR2## reacting the phosphonate with base to produce a phosphonate-stabilized carbanion, reacting the carbanion with a ketone of the formula: ##STR3## wherein T is as defined above, to produce an enol ether of the formula: ##STR4## then oxygenating the double bond in the enol ether to give the corresponding 1,2-dioxetane compound.

专利号:WO-2012159981-A3
优先权日:2011-05-20
标 题 :PROCESS FOR THE PREPARATION OF α-SUBSTITUTED KETONES AND THEIR APPLICATION IN SYNTHESIS OF PHARMACEUTICALLY ACTIVE COMPOUNDS
发明人：GAZIC SMILOVIC IVANA; SEECHURN CARIN; COLACOT THOMAS J
权利人:LEK PHARMACEUTICALS; GAZIC SMILOVIC IVANA; SEECHURN CARIN; COLACOT THOMAS J
摘要:The present invention relates to a novel one step preparation of 6-methoxy-2-phenyl-tetralone starting from 6-methoxy-tetralone and its use as an intermediate in the synthesis of pharmaceutically active compounds.

专利号:US-3962291-A
优先权日:1974-09-05
标 题:Total synthesis of 11-alkyl steroids
发明人：GARLAND ROBERT B; PAPPO RAPHAEL
权利人:SEARLE & CO
摘要:A novel total synthesis of 11-alkyl steroids, utilizing readily available and inexpensive raw materials, is described. The resulting products are useful and novel pharmacological agents possessing, for example, selective hormonal properties.

专利号:US-9409879-B2
优先权日:2011-03-29
标 题 :Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents
发明人：DAVIOUD-CHARVET ELISABETH; LANFRANCHI DON ANTOINE; JOHANN LAURE; WILLIAMS DAVID LEE; CESAR RODO ELENA
权利人:DAVIOUD-CHARVET ELISABETH; LANFRANCHI DON ANTOINE; JOHANN LAURE; WILLIAMS DAVID LEE; CESAR RODO ELENA; CENTRE NAT RECH SCIENT
摘要:Naphthoquinones, azanaphthoquinones and benxanthones, their process of synthesis and methods of their use as antimalarial or antischistosomal agents.

专利号:US-5756790-A
优先权日:1995-09-29
标题 :Optically active cobalt (II) complexes and method for the preparation of optically active alcohols
发明人：MUKAIYAMA TERUAKI; YOROZU KIYOTAKA; NAGATA TAKUSHI; YAMADA TORU; SUGI KIYOAKI
权利人:MITSUI PETROCHEMICAL IND
摘要:The invention provides a method for preparing an optically active alcohol comprising the step of reacting a ketone compound with a hydride reagent in the presence of an optically active metal compound. The resulting optically active alcohols are useful as intermediates for the synthesis of physiologically active compounds such as drugs and pesticides, functional materials such as liquid crystals, and raw materials for synthesis in fine chemistry. A novel optically active cobalt (II) complex useful as a catalyst is also provided.

专利号:US-8937188-B2
优先权日:2009-04-29
标 题:Process for the preparation of lasofoxifene tartrate
发明人：KHAN MUBEEN AHMED; TRIVEDI NIKHIL RASIKLAL; KANDASAMY NAGAN NIRMALAN; PATIL DAYAGHAN GANGADHAR; PANDEY VIPIN KUMAR; SINHA SUKUMAR
权利人:KHAN MUBEEN AHMED; TRIVEDI NIKHIL RASIKLAL; KANDASAMY NAGAN NIRMALAN; PATIL DAYAGHAN GANGADHAR; PANDEY VIPIN KUMAR; SINHA SUKUMAR; GLENMARK GENERICS LTD
摘要:A solid crystalline form of 1-(2-[4-(6-methoxy-3,4-dihydronaphthalene-1-y) phenoxy]ethyl)pyrrolidine, and a preparing process thereof are provided. The aforesaid compound is a key intermediate in the synthesis of lasofoxifene. A process for preparing lasofoxifene, a process for purifying lasofoxifene tartrate, and a crystalline form of lasofoxifene tartrate are also provided.